RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1

Ribosome-associated quality control (RQC) represents a rescue pathway in eukaryotic cells that is triggered upon translational stalling. Collided ribosomes are recognized for subsequent dissociation followed by degradation of nascent peptides. However, endogenous RQC-inducing sequences and the mecha...

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Veröffentlicht in:	Nature structural & molecular biology 2020-04, Vol.27 (4), p.323-332
Hauptverfasser:	Matsuo, Yoshitaka, Tesina, Petr, Nakajima, Shizuka, Mizuno, Masato, Endo, Akinori, Buschauer, Robert, Cheng, Jingdong, Shounai, Okuto, Ikeuchi, Ken, Saeki, Yasushi, Becker, Thomas, Beckmann, Roland, Inada, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/458/582 631/337/574/1789 631/535/1258/1259 Adenosine Triphosphate - chemistry Adenosine Triphosphate - genetics Biochemistry Biological Microscopy Biomedical and Life Sciences Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - ultrastructure DNA helicase Fungi Homeostasis Life Sciences Membrane Biology mRNA Peptides Peptides - chemistry Peptides - genetics Protein Biosynthesis Protein Structure Quality control Ribosomes Ribosomes - chemistry Ribosomes - genetics RNA, Messenger - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - ultrastructure Serine Endopeptidases - chemistry Serine Endopeptidases - genetics Serine Endopeptidases - ultrastructure Stalling Substrates Translation Ubiquitin Ubiquitin - chemistry Ubiquitin - genetics Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - ultrastructure Ubiquitination - genetics Yeast
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