Effects of Sulfonylureas on Periodontopathic Bacteria-Induced Inflammation

Interleukin-1β (IL-1β) is an inflammatory cytokine produced by monocytes/macrophages and is closely associated with periodontal diseases. The NLRP3 inflammasome is involved in IL-1β activation through pro–IL-1β processing and pyroptotic cell death in bacterial infection. Recently, glyburide, a hypog...

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Veröffentlicht in:	Journal of dental research 2020-07, Vol.99 (7), p.830-838
Hauptverfasser:	Kawahara, Y., Kaneko, T., Yoshinaga, Y., Arita, Y., Nakamura, K., Koga, C., Yoshimura, A., Sakagami, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Alveolar bone Animals Apoptosis Bacteria Caspase 1 Cell culture Cell death Cell differentiation Dentistry Enzyme-linked immunosorbent assay Gum disease IL-1β Inflammasomes Inflammation Inflammation - drug therapy Interleukin-1beta L-Lactate dehydrogenase Lactic acid Macrophages Metformin Monocytes NLR Family, Pyrin Domain-Containing 3 Protein Oral administration Osteoclasts Periodontal diseases Periodontitis Phorbol 12-myristate 13-acetate Rats Sulfonylurea Tolbutamide Western blotting
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