Central Nervous System Reorganization and Pain After Spinal Cord Injury: Possible Targets for Physical Therapy—A Systematic Review of Neuroimaging Studies
Abstract Background Pain is one of the main symptoms associated with spinal cord injury (SCI) and can be associated with changes to the central nervous system (CNS). Purpose This article provides an overview of the evidence relating to CNS changes (structural and functional) associated with pain in...
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| Veröffentlicht in: | Physical therapy 2020-06, Vol.100 (6), p.946-962 |
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| creator | Osinski, Thomas Acapo, Sessi Bensmail, Djamel Bouhassira, Didier Martinez, Valéria |
| description | Abstract
Background
Pain is one of the main symptoms associated with spinal cord injury (SCI) and can be associated with changes to the central nervous system (CNS).
Purpose
This article provides an overview of the evidence relating to CNS changes (structural and functional) associated with pain in SCIs.
Data Sources
A systematic review was performed, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, on PubMed, Embase, and Web of Science in March 2018.
Study Selection
Studies were selected if they concerned changes in the CNS of patients with SCI, regardless of the type of imagery.
Data Extraction
Data were extracted by 2 blinded reviewers.
Data Synthesis
There is moderate evidence for impaired electroencephalographic function and metabolic abnormalities in the anterior cingulate in patients experiencing pain. There is preliminary evidence that patients with pain have morphological and functional changes to the somatosensory cortex and alterations to thalamic metabolism. There are conflicting data regarding the relationships between lesion characteristics and pain. In contrast, patients without pain can display protective neuroplasticity.
Limitations and Conclusion
Further studies are required to elucidate fully the relationships between pain and neuroplasticity in patients with SCIs. However, current evidence might support the use of physical therapist treatments targeting CNS plasticity in patients with SCI pain. |
| doi_str_mv | 10.1093/ptj/pzaa043 |
| format | Article |
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Background
Pain is one of the main symptoms associated with spinal cord injury (SCI) and can be associated with changes to the central nervous system (CNS).
Purpose
This article provides an overview of the evidence relating to CNS changes (structural and functional) associated with pain in SCIs.
Data Sources
A systematic review was performed, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, on PubMed, Embase, and Web of Science in March 2018.
Study Selection
Studies were selected if they concerned changes in the CNS of patients with SCI, regardless of the type of imagery.
Data Extraction
Data were extracted by 2 blinded reviewers.
Data Synthesis
There is moderate evidence for impaired electroencephalographic function and metabolic abnormalities in the anterior cingulate in patients experiencing pain. There is preliminary evidence that patients with pain have morphological and functional changes to the somatosensory cortex and alterations to thalamic metabolism. There are conflicting data regarding the relationships between lesion characteristics and pain. In contrast, patients without pain can display protective neuroplasticity.
Limitations and Conclusion
Further studies are required to elucidate fully the relationships between pain and neuroplasticity in patients with SCIs. However, current evidence might support the use of physical therapist treatments targeting CNS plasticity in patients with SCI pain.</description><identifier>ISSN: 0031-9023</identifier><identifier>ISSN: 1538-6724</identifier><identifier>EISSN: 1538-6724</identifier><identifier>DOI: 10.1093/ptj/pzaa043</identifier><identifier>PMID: 32201890</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adult ; Brain - diagnostic imaging ; Brain - metabolism ; Brain - pathology ; Brain - physiopathology ; Central Nervous System - diagnostic imaging ; Central Nervous System - metabolism ; Central Nervous System - pathology ; Central Nervous System - physiopathology ; Chronic Pain - etiology ; Chronic Pain - physiopathology ; Electroencephalography - methods ; Gyrus Cinguli - diagnostic imaging ; Gyrus Cinguli - physiopathology ; Humans ; Magnetic Resonance Imaging - methods ; Nervous system ; Neuralgia - etiology ; Neuralgia - physiopathology ; Neuroimaging ; Neuroimaging - methods ; Neuronal Plasticity - physiology ; Neuroplasticity ; Pain ; Physical therapy ; Selection Bias ; Somatosensory Cortex - diagnostic imaging ; Somatosensory Cortex - pathology ; Somatosensory Cortex - physiopathology ; Spinal Cord - diagnostic imaging ; Spinal Cord - metabolism ; Spinal Cord - pathology ; Spinal Cord - physiopathology ; Spinal cord injuries ; Spinal Cord Injuries - complications ; Spinal Cord Injuries - diagnostic imaging ; Spinal Cord Injuries - metabolism ; Spinal Cord Injuries - physiopathology ; Systematic review ; Thalamus - diagnostic imaging ; Thalamus - metabolism</subject><ispartof>Physical therapy, 2020-06, Vol.100 (6), p.946-962</ispartof><rights>2020 American Physical Therapy Association 2020</rights><rights>2020 American Physical Therapy Association.</rights><rights>2020 American Physical Therapy Association</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-45cfafdbbc9fbbb204a4cadb0cca6f7d6557492713ac863d0610248e8f2d33483</citedby><cites>FETCH-LOGICAL-c385t-45cfafdbbc9fbbb204a4cadb0cca6f7d6557492713ac863d0610248e8f2d33483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32201890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osinski, Thomas</creatorcontrib><creatorcontrib>Acapo, Sessi</creatorcontrib><creatorcontrib>Bensmail, Djamel</creatorcontrib><creatorcontrib>Bouhassira, Didier</creatorcontrib><creatorcontrib>Martinez, Valéria</creatorcontrib><title>Central Nervous System Reorganization and Pain After Spinal Cord Injury: Possible Targets for Physical Therapy—A Systematic Review of Neuroimaging Studies</title><title>Physical therapy</title><addtitle>Phys Ther</addtitle><description>Abstract
Background
Pain is one of the main symptoms associated with spinal cord injury (SCI) and can be associated with changes to the central nervous system (CNS).
Purpose
This article provides an overview of the evidence relating to CNS changes (structural and functional) associated with pain in SCIs.
Data Sources
A systematic review was performed, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, on PubMed, Embase, and Web of Science in March 2018.
Study Selection
Studies were selected if they concerned changes in the CNS of patients with SCI, regardless of the type of imagery.
Data Extraction
Data were extracted by 2 blinded reviewers.
Data Synthesis
There is moderate evidence for impaired electroencephalographic function and metabolic abnormalities in the anterior cingulate in patients experiencing pain. There is preliminary evidence that patients with pain have morphological and functional changes to the somatosensory cortex and alterations to thalamic metabolism. There are conflicting data regarding the relationships between lesion characteristics and pain. In contrast, patients without pain can display protective neuroplasticity.
Limitations and Conclusion
Further studies are required to elucidate fully the relationships between pain and neuroplasticity in patients with SCIs. However, current evidence might support the use of physical therapist treatments targeting CNS plasticity in patients with SCI pain.</description><subject>Adult</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Central Nervous System - diagnostic imaging</subject><subject>Central Nervous System - metabolism</subject><subject>Central Nervous System - pathology</subject><subject>Central Nervous System - physiopathology</subject><subject>Chronic Pain - etiology</subject><subject>Chronic Pain - physiopathology</subject><subject>Electroencephalography - methods</subject><subject>Gyrus Cinguli - diagnostic imaging</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Nervous system</subject><subject>Neuralgia - etiology</subject><subject>Neuralgia - physiopathology</subject><subject>Neuroimaging</subject><subject>Neuroimaging - methods</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neuroplasticity</subject><subject>Pain</subject><subject>Physical therapy</subject><subject>Selection Bias</subject><subject>Somatosensory Cortex - diagnostic imaging</subject><subject>Somatosensory Cortex - pathology</subject><subject>Somatosensory Cortex - physiopathology</subject><subject>Spinal Cord - diagnostic imaging</subject><subject>Spinal Cord - metabolism</subject><subject>Spinal Cord - pathology</subject><subject>Spinal Cord - physiopathology</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - complications</subject><subject>Spinal Cord Injuries - diagnostic imaging</subject><subject>Spinal Cord Injuries - metabolism</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Systematic review</subject><subject>Thalamus - diagnostic imaging</subject><subject>Thalamus - metabolism</subject><issn>0031-9023</issn><issn>1538-6724</issn><issn>1538-6724</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctqGzEYhUVIaNy0q-yLIFAKZRLdZqzJzpheAiE1tbseNLo4MmNpImlSJqs-RJd9uj5JFexk0UVW2nz6Dv85AJxidI5RTS_6tLnoH4RAjB6ACS4pL6opYYdgghDFRY0IPQavY9wghPCU1a_AMSUEYV6jCfgz1y4F0cEbHe79EOFyjElv4Xftw1o4-yCS9Q4Kp-BCWAdnJukAl711-c_cBwWv3GYI4yVc-Bht22m4EmGtU4TGB7i4HaOVGV3d6iD68e-v37N9RBbLHHNv9U_oTc4fgrdbsbZuDZdpUFbHN-DIiC7qt_v3BPz4_Gk1_1pcf_tyNZ9dF5LyMhWslEYY1bayNm3bEsQEk0K1SEpRmamqyjKfTaaYCskrqlCFEWFcc0MUpYzTE_Bh5-2Dvxt0TM3WRqm7TjidO2kI5ZiXCBOc0bP_0I0fQi4jU4xmL6b4kfq4o2TIrQRtmj7k28LYYNQ8jtbk0Zr9aJl-t3cO7VarZ_ZppQy83wF-6F80_QNERqQw</recordid><startdate>20200623</startdate><enddate>20200623</enddate><creator>Osinski, Thomas</creator><creator>Acapo, Sessi</creator><creator>Bensmail, Djamel</creator><creator>Bouhassira, Didier</creator><creator>Martinez, Valéria</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20200623</creationdate><title>Central Nervous System Reorganization and Pain After Spinal Cord Injury: Possible Targets for Physical Therapy—A Systematic Review of Neuroimaging Studies</title><author>Osinski, Thomas ; Acapo, Sessi ; Bensmail, Djamel ; Bouhassira, Didier ; Martinez, Valéria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-45cfafdbbc9fbbb204a4cadb0cca6f7d6557492713ac863d0610248e8f2d33483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Central Nervous System - diagnostic imaging</topic><topic>Central Nervous System - metabolism</topic><topic>Central Nervous System - pathology</topic><topic>Central Nervous System - physiopathology</topic><topic>Chronic Pain - etiology</topic><topic>Chronic Pain - physiopathology</topic><topic>Electroencephalography - methods</topic><topic>Gyrus Cinguli - diagnostic imaging</topic><topic>Gyrus Cinguli - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Nervous system</topic><topic>Neuralgia - etiology</topic><topic>Neuralgia - physiopathology</topic><topic>Neuroimaging</topic><topic>Neuroimaging - methods</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neuroplasticity</topic><topic>Pain</topic><topic>Physical therapy</topic><topic>Selection Bias</topic><topic>Somatosensory Cortex - diagnostic imaging</topic><topic>Somatosensory Cortex - pathology</topic><topic>Somatosensory Cortex - physiopathology</topic><topic>Spinal Cord - diagnostic imaging</topic><topic>Spinal Cord - metabolism</topic><topic>Spinal Cord - pathology</topic><topic>Spinal Cord - physiopathology</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - complications</topic><topic>Spinal Cord Injuries - diagnostic imaging</topic><topic>Spinal Cord Injuries - metabolism</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Systematic review</topic><topic>Thalamus - diagnostic imaging</topic><topic>Thalamus - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Osinski, Thomas</creatorcontrib><creatorcontrib>Acapo, Sessi</creatorcontrib><creatorcontrib>Bensmail, Djamel</creatorcontrib><creatorcontrib>Bouhassira, Didier</creatorcontrib><creatorcontrib>Martinez, Valéria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Physical therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osinski, Thomas</au><au>Acapo, Sessi</au><au>Bensmail, Djamel</au><au>Bouhassira, Didier</au><au>Martinez, Valéria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central Nervous System Reorganization and Pain After Spinal Cord Injury: Possible Targets for Physical Therapy—A Systematic Review of Neuroimaging Studies</atitle><jtitle>Physical therapy</jtitle><addtitle>Phys Ther</addtitle><date>2020-06-23</date><risdate>2020</risdate><volume>100</volume><issue>6</issue><spage>946</spage><epage>962</epage><pages>946-962</pages><issn>0031-9023</issn><issn>1538-6724</issn><eissn>1538-6724</eissn><abstract>Abstract
Background
Pain is one of the main symptoms associated with spinal cord injury (SCI) and can be associated with changes to the central nervous system (CNS).
Purpose
This article provides an overview of the evidence relating to CNS changes (structural and functional) associated with pain in SCIs.
Data Sources
A systematic review was performed, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, on PubMed, Embase, and Web of Science in March 2018.
Study Selection
Studies were selected if they concerned changes in the CNS of patients with SCI, regardless of the type of imagery.
Data Extraction
Data were extracted by 2 blinded reviewers.
Data Synthesis
There is moderate evidence for impaired electroencephalographic function and metabolic abnormalities in the anterior cingulate in patients experiencing pain. There is preliminary evidence that patients with pain have morphological and functional changes to the somatosensory cortex and alterations to thalamic metabolism. There are conflicting data regarding the relationships between lesion characteristics and pain. In contrast, patients without pain can display protective neuroplasticity.
Limitations and Conclusion
Further studies are required to elucidate fully the relationships between pain and neuroplasticity in patients with SCIs. However, current evidence might support the use of physical therapist treatments targeting CNS plasticity in patients with SCI pain.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>32201890</pmid><doi>10.1093/ptj/pzaa043</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Brain - diagnostic imaging Brain - metabolism Brain - pathology Brain - physiopathology Central Nervous System - diagnostic imaging Central Nervous System - metabolism Central Nervous System - pathology Central Nervous System - physiopathology Chronic Pain - etiology Chronic Pain - physiopathology Electroencephalography - methods Gyrus Cinguli - diagnostic imaging Gyrus Cinguli - physiopathology Humans Magnetic Resonance Imaging - methods Nervous system Neuralgia - etiology Neuralgia - physiopathology Neuroimaging Neuroimaging - methods Neuronal Plasticity - physiology Neuroplasticity Pain Physical therapy Selection Bias Somatosensory Cortex - diagnostic imaging Somatosensory Cortex - pathology Somatosensory Cortex - physiopathology Spinal Cord - diagnostic imaging Spinal Cord - metabolism Spinal Cord - pathology Spinal Cord - physiopathology Spinal cord injuries Spinal Cord Injuries - complications Spinal Cord Injuries - diagnostic imaging Spinal Cord Injuries - metabolism Spinal Cord Injuries - physiopathology Systematic review Thalamus - diagnostic imaging Thalamus - metabolism |
| title | Central Nervous System Reorganization and Pain After Spinal Cord Injury: Possible Targets for Physical Therapy—A Systematic Review of Neuroimaging Studies |
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