Insulin-like growth factor-1 receptor (IGF-1R) expression on circulating tumor cells (CTCs) and metastatic breast cancer outcome: results from the TransMYME trial

Purpose To evaluate the prognostic value of IGF-1R expression on circulating tumor cells (CTCs) in a prospective randomized clinical trial comparing chemotherapy plus metformin with chemotherapy alone in metastatic breast cancer (MBC) patients. Methods CTCs were collected at baseline and at the end...

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Veröffentlicht in:	Breast cancer research and treatment 2020-05, Vol.181 (1), p.61-68
Hauptverfasser:	Gennari, Alessandra, Foca, Flavia, Zamarchi, Rita, Rocca, Andrea, Amadori, Dino, De Censi, Andrea, Bologna, Alessandra, Cavanna, Luigi, Gianni, Lorenzo, Scaltriti, Laura, Rossi, Elisabetta, Facchinetti, Antonella, Martini, Veronica, Bruzzi, Paolo, Nanni, Oriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - blood Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer research Chemotherapy Clinical Trial Clinical trials Clinical Trials, Phase II as Topic Female Follow-Up Studies Humans Insulin Insulin-like growth factor I Insulin-like growth factors Medicine Medicine & Public Health Metastases Metastasis Metformin Middle Aged Multivariate analysis Neoplasm Metastasis Neoplastic Cells, Circulating - metabolism Neoplastic Cells, Circulating - pathology Oncology Prognosis Prospective Studies Randomized Controlled Trials as Topic Receptor, IGF Type 1 - metabolism Survival Rate Treatment Outcome Tumor cells
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