Nature's remedy to phosphate woes: calciprotein particles regulate systemic mineral metabolism

Nature's remedy to phosphate woes: calciprotein particles regulate systemic mineral metabolism

Calciprotein particles, colloidal complexes of calcium phosphate and plasma protein fetuin-A, have emerged as mediators of multiple biological effects attributed to phosphate. A new study postulates that circulating calciprotein particles, not phosphate, regulate the production of the major bone-der...

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Veröffentlicht in:Kidney international 2020-04, Vol.97 (4), p.648-651
Hauptverfasser: Jahnen-Dechent, Willi, Smith, Edward R
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container_title Kidney international
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description Calciprotein particles, colloidal complexes of calcium phosphate and plasma protein fetuin-A, have emerged as mediators of multiple biological effects attributed to phosphate. A new study postulates that circulating calciprotein particles, not phosphate, regulate the production of the major bone-derived phosphatonin, fibroblast growth factor-23. The signaling events coupling calciprotein particles sensing in bone to fibroblast growth factor-23 secretion remain to be established.
doi_str_mv 10.1016/j.kint.2019.12.018
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title Nature's remedy to phosphate woes: calciprotein particles regulate systemic mineral metabolism
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