Amyloid β-protein and beyond: the path forward in Alzheimer’s disease

•Lack of success of most anti-amyloid trials in symptomatic AD is attributable in part to the pathology being too advanced.•Progress in quantifying tau and Aβ in plasma suggests that changes in these analytes may even predict AD presymptomatically.•Anti-Aβ immunotherapy should include secondary prev...

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Veröffentlicht in:Current opinion in neurobiology 2020-04, Vol.61, p.116-124
Hauptverfasser: Walsh, Dominic M, Selkoe, Dennis J
Format: Artikel
Sprache:eng
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