c-Rel gain in B cells drives germinal center reactions and autoantibody production

Single-nucleotide polymorphisms and locus amplification fink the NF-kappa B transcription factor c-Rel to human autoimmune diseases and B cell lymphomas, respectively. However, the functional consequences of enhanced c-Rel levels remain enigmatic. Here, we overexpressed c-Rel specifically in mouse B...

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Veröffentlicht in:	The Journal of clinical investigation 2020-06, Vol.130 (6), p.3270-3286
Hauptverfasser:	Kober-Hasslacher, Maike, Oh-Strauss, Hyunju, Kumar, Dilip, Soberon, Valeria, Diehl, Carina, Lech, Maciej, Engleitner, Thomas, Katab, Eslam, Fernandez-Saiz, Jvanesa, Piontek, Guido, Li, Hongwei, Menze, Bjorn, Ziegenhain, Christoph, Enard, Wolfgang, Rad, Roland, Boettcher, Jan P., Anders, Hans-Joachim, Rudelius, Martina, Schmidt-Supprian, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibody Formation Antigens Arthritis Artificial chromosomes Autoantibodies Autoantibodies - genetics Autoantibodies - immunology Autoimmune diseases Autoimmunity B cells B-cell lymphoma Biomedical research Bone marrow c-Rel protein Cell differentiation Gene loci Gene regulation Genetic aspects Genetic engineering Germinal Center - immunology Germinal Center - pathology Germinal centers Immunoglobulins Life Sciences & Biomedicine Lymphatic system Lymphocytes Lymphocytes B Lymphoma Medicine, Research & Experimental Mice Mice, Transgenic NF-κB protein Nuclear transport Plasma Plasma cells Plasma Cells - immunology Plasma Cells - pathology Polymorphism, Single Nucleotide Proteins Proto-Oncogene Proteins c-rel - genetics Proto-Oncogene Proteins c-rel - immunology Rel protein Research & Experimental Medicine Science & Technology Scientific equipment industry Single nucleotide polymorphisms Single-nucleotide polymorphism Spleen Transcription factors
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