Angiopoietin-2 Is an Early Predictor for Acute Gastrointestinal Injury and Intestinal Barrier Dysfunction in Patients with Acute Pancreatitis
Backgrounds Angiopoietin-2 (Ang-2) is a new predictor for acute pancreatitis (AP). Aims To assess the predictive value of Ang-2 in determining the progress of AP and the subsequent acute gastrointestinal injury (AGI). Methods This was a prospective study that enrolled 170 patients with AP and 100 he...
Gespeichert in:
| Veröffentlicht in: | Digestive diseases and sciences 2021, Vol.66 (1), p.114-120 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 120 |
|---|---|
| container_issue | 1 |
| container_start_page | 114 |
| container_title | Digestive diseases and sciences |
| container_volume | 66 |
| creator | Huang, Qing Wu, Zhe Chi, Cheng Wu, Chunbo Su, Lin Zhang, Yuanyuan Zhu, Jihong Liu, Yulan |
| description | Backgrounds
Angiopoietin-2 (Ang-2) is a new predictor for acute pancreatitis (AP).
Aims
To assess the predictive value of Ang-2 in determining the progress of AP and the subsequent acute gastrointestinal injury (AGI).
Methods
This was a prospective study that enrolled 170 patients with AP and 100 healthy controls. Blood samples were collected within 24 h of the onset of AP.
Results
The majority (108) of the patients were categorized as having MAP with the rest (62) classified as suffering from SAP. Considering AGI grading, there were 118 grade 1 and 12 grade 4 patients; in grades 2 and 3, there were 20 patients each. AP was accompanied by MODS and pancreatic necrosis in 46 and 24 cases, respectively. Eighty patients were admitted to the ICU, while mortality was reported among 7.1% patients. The plasma Ang-2 levels were higher among patients with AP than in controls. A similar trend prevailed, in patients with SAP compared to those with MAP. Ang-2 was significantly increased from AGI grade 1 through to grade 4, showing a desirable positive predictive accuracy. Moreover, Ang-2 also showed strong correlations with intestinal permeability as evaluated by d-lactate (DLA), diamine oxidase (DAO), and intestinal fatty acid binding proteins (I-FABPs). Tools (Ranson and APACHE II scores, CRP), which are used more conventionally, could not effectively distinguish the various grades of AGI. Furthermore, Ang-2 predicted poor prognosis and adverse outcomes, including mortality, among patients with AP.
Conclusions
This study showed Ang-2 to be an accurate early predictor for SAP, AGI, and intestinal barrier dysfunction, outperforming conventional biomarkers. Ang-2 levels also predicted the adverse outcomes and mortality due to AP. |
| doi_str_mv | 10.1007/s10620-020-06138-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2381624770</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712935062</galeid><sourcerecordid>A712935062</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-80c4828833482e7adb65b266975a5dc09d1bf75be503ae04a0f941d8e2da89d63</originalsourceid><addsrcrecordid>eNp9ks1uEzEQxy1ERUPhBTggS1y4bOuPXa_3GEopkSqRA5wtrz0bHG3sYHtV5SF4Z7xKKFBVyBp5NPP7j2Y0g9AbSi4pIe1VokQwUpHZBOWyIs_QgjYtr1gj5HO0IFQUn1Jxjl6mtCWEdC0VL9A5Z7TjspEL9HPpNy7sg4PsfMXwKmHt8Y2O4wGvI1hncoh4KLY0UwZ8q1OOwfkMqQj0iFd-O8VDEdniPkQ_6BgdRPzxkIbJm-yCx87jtc4OfE743uXvp4pr7U2EksguvUJngx4TvD79F-jbp5uv15-ruy-3q-vlXWXqmuVKElNLJiXn5YNW2140PROiaxvdWEM6S_uhbXpoCNdAak2GrqZWArNadlbwC_T-WHcfw4-pNK12LhkYR-0hTEkxLqlgdduSgr57hG7DFMuMhZqBjnbyL2qjR1DODyFHbeaiatlS1vGmrKpQl09Q5VnYORM8DK7E_xGwo8DEkFKEQe2j2-l4UJSo-QbU8QYUmW2-ATX38vbU8dTvwD5Ifi-9APwIpJLyG4h_RvpP2V-Ad7uv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2477091980</pqid></control><display><type>article</type><title>Angiopoietin-2 Is an Early Predictor for Acute Gastrointestinal Injury and Intestinal Barrier Dysfunction in Patients with Acute Pancreatitis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Huang, Qing ; Wu, Zhe ; Chi, Cheng ; Wu, Chunbo ; Su, Lin ; Zhang, Yuanyuan ; Zhu, Jihong ; Liu, Yulan</creator><creatorcontrib>Huang, Qing ; Wu, Zhe ; Chi, Cheng ; Wu, Chunbo ; Su, Lin ; Zhang, Yuanyuan ; Zhu, Jihong ; Liu, Yulan</creatorcontrib><description>Backgrounds
Angiopoietin-2 (Ang-2) is a new predictor for acute pancreatitis (AP).
Aims
To assess the predictive value of Ang-2 in determining the progress of AP and the subsequent acute gastrointestinal injury (AGI).
Methods
This was a prospective study that enrolled 170 patients with AP and 100 healthy controls. Blood samples were collected within 24 h of the onset of AP.
Results
The majority (108) of the patients were categorized as having MAP with the rest (62) classified as suffering from SAP. Considering AGI grading, there were 118 grade 1 and 12 grade 4 patients; in grades 2 and 3, there were 20 patients each. AP was accompanied by MODS and pancreatic necrosis in 46 and 24 cases, respectively. Eighty patients were admitted to the ICU, while mortality was reported among 7.1% patients. The plasma Ang-2 levels were higher among patients with AP than in controls. A similar trend prevailed, in patients with SAP compared to those with MAP. Ang-2 was significantly increased from AGI grade 1 through to grade 4, showing a desirable positive predictive accuracy. Moreover, Ang-2 also showed strong correlations with intestinal permeability as evaluated by d-lactate (DLA), diamine oxidase (DAO), and intestinal fatty acid binding proteins (I-FABPs). Tools (Ranson and APACHE II scores, CRP), which are used more conventionally, could not effectively distinguish the various grades of AGI. Furthermore, Ang-2 predicted poor prognosis and adverse outcomes, including mortality, among patients with AP.
Conclusions
This study showed Ang-2 to be an accurate early predictor for SAP, AGI, and intestinal barrier dysfunction, outperforming conventional biomarkers. Ang-2 levels also predicted the adverse outcomes and mortality due to AP.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-020-06138-0</identifier><identifier>PMID: 32193858</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acute Disease ; Adult ; Aged ; Angiopoietin-2 - blood ; Angiopoietin-2 - metabolism ; Binding proteins ; Biochemistry ; Biomarkers ; Biomarkers - blood ; Care and treatment ; Disease ; Early Diagnosis ; Fatty acids ; Female ; Gastroenterology ; Gastrointestinal Diseases - blood ; Gastrointestinal Diseases - diagnosis ; Health aspects ; Hepatology ; Humans ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - pathology ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Mortality ; Multiple organ dysfunction syndrome ; Normal distribution ; Oncology ; Original Article ; Pancreatitis ; Pancreatitis - blood ; Pancreatitis - diagnosis ; Patients ; Permeability ; Predictive Value of Tests ; Prospective Studies ; Protein binding ; Transplant Surgery</subject><ispartof>Digestive diseases and sciences, 2021, Vol.66 (1), p.114-120</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-80c4828833482e7adb65b266975a5dc09d1bf75be503ae04a0f941d8e2da89d63</citedby><cites>FETCH-LOGICAL-c442t-80c4828833482e7adb65b266975a5dc09d1bf75be503ae04a0f941d8e2da89d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-020-06138-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-020-06138-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32193858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Qing</creatorcontrib><creatorcontrib>Wu, Zhe</creatorcontrib><creatorcontrib>Chi, Cheng</creatorcontrib><creatorcontrib>Wu, Chunbo</creatorcontrib><creatorcontrib>Su, Lin</creatorcontrib><creatorcontrib>Zhang, Yuanyuan</creatorcontrib><creatorcontrib>Zhu, Jihong</creatorcontrib><creatorcontrib>Liu, Yulan</creatorcontrib><title>Angiopoietin-2 Is an Early Predictor for Acute Gastrointestinal Injury and Intestinal Barrier Dysfunction in Patients with Acute Pancreatitis</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Backgrounds
Angiopoietin-2 (Ang-2) is a new predictor for acute pancreatitis (AP).
Aims
To assess the predictive value of Ang-2 in determining the progress of AP and the subsequent acute gastrointestinal injury (AGI).
Methods
This was a prospective study that enrolled 170 patients with AP and 100 healthy controls. Blood samples were collected within 24 h of the onset of AP.
Results
The majority (108) of the patients were categorized as having MAP with the rest (62) classified as suffering from SAP. Considering AGI grading, there were 118 grade 1 and 12 grade 4 patients; in grades 2 and 3, there were 20 patients each. AP was accompanied by MODS and pancreatic necrosis in 46 and 24 cases, respectively. Eighty patients were admitted to the ICU, while mortality was reported among 7.1% patients. The plasma Ang-2 levels were higher among patients with AP than in controls. A similar trend prevailed, in patients with SAP compared to those with MAP. Ang-2 was significantly increased from AGI grade 1 through to grade 4, showing a desirable positive predictive accuracy. Moreover, Ang-2 also showed strong correlations with intestinal permeability as evaluated by d-lactate (DLA), diamine oxidase (DAO), and intestinal fatty acid binding proteins (I-FABPs). Tools (Ranson and APACHE II scores, CRP), which are used more conventionally, could not effectively distinguish the various grades of AGI. Furthermore, Ang-2 predicted poor prognosis and adverse outcomes, including mortality, among patients with AP.
Conclusions
This study showed Ang-2 to be an accurate early predictor for SAP, AGI, and intestinal barrier dysfunction, outperforming conventional biomarkers. Ang-2 levels also predicted the adverse outcomes and mortality due to AP.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Angiopoietin-2 - blood</subject><subject>Angiopoietin-2 - metabolism</subject><subject>Binding proteins</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Care and treatment</subject><subject>Disease</subject><subject>Early Diagnosis</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastrointestinal Diseases - blood</subject><subject>Gastrointestinal Diseases - diagnosis</subject><subject>Health aspects</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - pathology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multiple organ dysfunction syndrome</subject><subject>Normal distribution</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pancreatitis</subject><subject>Pancreatitis - blood</subject><subject>Pancreatitis - diagnosis</subject><subject>Patients</subject><subject>Permeability</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Protein binding</subject><subject>Transplant Surgery</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9ks1uEzEQxy1ERUPhBTggS1y4bOuPXa_3GEopkSqRA5wtrz0bHG3sYHtV5SF4Z7xKKFBVyBp5NPP7j2Y0g9AbSi4pIe1VokQwUpHZBOWyIs_QgjYtr1gj5HO0IFQUn1Jxjl6mtCWEdC0VL9A5Z7TjspEL9HPpNy7sg4PsfMXwKmHt8Y2O4wGvI1hncoh4KLY0UwZ8q1OOwfkMqQj0iFd-O8VDEdniPkQ_6BgdRPzxkIbJm-yCx87jtc4OfE743uXvp4pr7U2EksguvUJngx4TvD79F-jbp5uv15-ruy-3q-vlXWXqmuVKElNLJiXn5YNW2140PROiaxvdWEM6S_uhbXpoCNdAak2GrqZWArNadlbwC_T-WHcfw4-pNK12LhkYR-0hTEkxLqlgdduSgr57hG7DFMuMhZqBjnbyL2qjR1DODyFHbeaiatlS1vGmrKpQl09Q5VnYORM8DK7E_xGwo8DEkFKEQe2j2-l4UJSo-QbU8QYUmW2-ATX38vbU8dTvwD5Ifi-9APwIpJLyG4h_RvpP2V-Ad7uv</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Huang, Qing</creator><creator>Wu, Zhe</creator><creator>Chi, Cheng</creator><creator>Wu, Chunbo</creator><creator>Su, Lin</creator><creator>Zhang, Yuanyuan</creator><creator>Zhu, Jihong</creator><creator>Liu, Yulan</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2021</creationdate><title>Angiopoietin-2 Is an Early Predictor for Acute Gastrointestinal Injury and Intestinal Barrier Dysfunction in Patients with Acute Pancreatitis</title><author>Huang, Qing ; Wu, Zhe ; Chi, Cheng ; Wu, Chunbo ; Su, Lin ; Zhang, Yuanyuan ; Zhu, Jihong ; Liu, Yulan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-80c4828833482e7adb65b266975a5dc09d1bf75be503ae04a0f941d8e2da89d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Angiopoietin-2 - blood</topic><topic>Angiopoietin-2 - metabolism</topic><topic>Binding proteins</topic><topic>Biochemistry</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Care and treatment</topic><topic>Disease</topic><topic>Early Diagnosis</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastrointestinal Diseases - blood</topic><topic>Gastrointestinal Diseases - diagnosis</topic><topic>Health aspects</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - pathology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multiple organ dysfunction syndrome</topic><topic>Normal distribution</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pancreatitis</topic><topic>Pancreatitis - blood</topic><topic>Pancreatitis - diagnosis</topic><topic>Patients</topic><topic>Permeability</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Protein binding</topic><topic>Transplant Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Qing</creatorcontrib><creatorcontrib>Wu, Zhe</creatorcontrib><creatorcontrib>Chi, Cheng</creatorcontrib><creatorcontrib>Wu, Chunbo</creatorcontrib><creatorcontrib>Su, Lin</creatorcontrib><creatorcontrib>Zhang, Yuanyuan</creatorcontrib><creatorcontrib>Zhu, Jihong</creatorcontrib><creatorcontrib>Liu, Yulan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Qing</au><au>Wu, Zhe</au><au>Chi, Cheng</au><au>Wu, Chunbo</au><au>Su, Lin</au><au>Zhang, Yuanyuan</au><au>Zhu, Jihong</au><au>Liu, Yulan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiopoietin-2 Is an Early Predictor for Acute Gastrointestinal Injury and Intestinal Barrier Dysfunction in Patients with Acute Pancreatitis</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2021</date><risdate>2021</risdate><volume>66</volume><issue>1</issue><spage>114</spage><epage>120</epage><pages>114-120</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract>Backgrounds
Angiopoietin-2 (Ang-2) is a new predictor for acute pancreatitis (AP).
Aims
To assess the predictive value of Ang-2 in determining the progress of AP and the subsequent acute gastrointestinal injury (AGI).
Methods
This was a prospective study that enrolled 170 patients with AP and 100 healthy controls. Blood samples were collected within 24 h of the onset of AP.
Results
The majority (108) of the patients were categorized as having MAP with the rest (62) classified as suffering from SAP. Considering AGI grading, there were 118 grade 1 and 12 grade 4 patients; in grades 2 and 3, there were 20 patients each. AP was accompanied by MODS and pancreatic necrosis in 46 and 24 cases, respectively. Eighty patients were admitted to the ICU, while mortality was reported among 7.1% patients. The plasma Ang-2 levels were higher among patients with AP than in controls. A similar trend prevailed, in patients with SAP compared to those with MAP. Ang-2 was significantly increased from AGI grade 1 through to grade 4, showing a desirable positive predictive accuracy. Moreover, Ang-2 also showed strong correlations with intestinal permeability as evaluated by d-lactate (DLA), diamine oxidase (DAO), and intestinal fatty acid binding proteins (I-FABPs). Tools (Ranson and APACHE II scores, CRP), which are used more conventionally, could not effectively distinguish the various grades of AGI. Furthermore, Ang-2 predicted poor prognosis and adverse outcomes, including mortality, among patients with AP.
Conclusions
This study showed Ang-2 to be an accurate early predictor for SAP, AGI, and intestinal barrier dysfunction, outperforming conventional biomarkers. Ang-2 levels also predicted the adverse outcomes and mortality due to AP.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32193858</pmid><doi>10.1007/s10620-020-06138-0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2021, Vol.66 (1), p.114-120 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2381624770 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acute Disease Adult Aged Angiopoietin-2 - blood Angiopoietin-2 - metabolism Binding proteins Biochemistry Biomarkers Biomarkers - blood Care and treatment Disease Early Diagnosis Fatty acids Female Gastroenterology Gastrointestinal Diseases - blood Gastrointestinal Diseases - diagnosis Health aspects Hepatology Humans Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Mortality Multiple organ dysfunction syndrome Normal distribution Oncology Original Article Pancreatitis Pancreatitis - blood Pancreatitis - diagnosis Patients Permeability Predictive Value of Tests Prospective Studies Protein binding Transplant Surgery |
| title | Angiopoietin-2 Is an Early Predictor for Acute Gastrointestinal Injury and Intestinal Barrier Dysfunction in Patients with Acute Pancreatitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T03%3A47%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Angiopoietin-2%20Is%20an%20Early%20Predictor%20for%20Acute%20Gastrointestinal%20Injury%20and%20Intestinal%20Barrier%20Dysfunction%20in%20Patients%20with%20Acute%20Pancreatitis&rft.jtitle=Digestive%20diseases%20and%20sciences&rft.au=Huang,%20Qing&rft.date=2021&rft.volume=66&rft.issue=1&rft.spage=114&rft.epage=120&rft.pages=114-120&rft.issn=0163-2116&rft.eissn=1573-2568&rft_id=info:doi/10.1007/s10620-020-06138-0&rft_dat=%3Cgale_proqu%3EA712935062%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2477091980&rft_id=info:pmid/32193858&rft_galeid=A712935062&rfr_iscdi=true |