Enhanced cellular uptake efficiency of DCM probes or SN38 conjugating with phenylboronic acids

[Display omitted] High-level of sialic acid (SA) expression on the surface of cancer cells is observed extremely common. Phenylboronic acids (PBAs) have a high affinity with SA. The cellular uptake efficiency could be enhanced by the strategy of introducing PBA fragments to the compounds. In this wo...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2020-04, Vol.28 (7), p.115377-115377, Article 115377
Hauptverfasser:	Zhang, Qiumeng, Che, Rui, Lu, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Biological Transport Boronic Acids - chemistry Cell Proliferation - drug effects Cellular uptake Drug Design Fluorescent Dyes Hep G2 Cells Humans Irinotecan - chemistry Irinotecan - metabolism Molecular Structure Phenylboronic acid Probe Pyrans - chemistry Sialic acid SN38
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