Pediatric Guillain-Barré Syndrome in a 30-Year Nationwide Cohort
Guillain-Barré syndrome is the most common cause of acute flaccid paresis in childhood. Few validated large-scale population-based data are available concerning pediatric Guillain-Barré syndrome, including incidence, risk factors, and initial clinical characteristics. In the Danish National Patient...
Gespeichert in:
Veröffentlicht in: | Pediatric neurology 2020-06, Vol.107, p.57-63 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 63 |
---|---|
container_issue | |
container_start_page | 57 |
container_title | Pediatric neurology |
container_volume | 107 |
creator | Levison, Lotte Sahin Thomsen, Reimar Wernich Markvardsen, Lars Kjøbsted Christensen, Diana Hedevang Sindrup, Søren Hein Andersen, Henning |
description | Guillain-Barré syndrome is the most common cause of acute flaccid paresis in childhood. Few validated large-scale population-based data are available concerning pediatric Guillain-Barré syndrome, including incidence, risk factors, and initial clinical characteristics.
In the Danish National Patient Registry, we identified all children aged below 16 years (N = 212) diagnosed with Guillain-Barré syndrome and admitted to any Danish department of pediatrics between 1987 and 2016. A total of 145 (68%) medical files could be retrieved and reviewed, enabling classification of patients with true Guillain-Barré syndrome. The nationwide Guillain-Barré syndrome incidence rate was calculated and stratified by age, gender, time periods, and season. Risk factors and initial Guillain-Barré syndrome characteristics were assessed by medical record review.
The positive predictive value of Guillain-Barré syndrome diagnosis codes was 86%. The crude Guillain-Barré syndrome incidence rate was 0.69 per 100,000 person years and peaked at two years of age. The incidence rate was higher among men (0.80) than women (0.58) and was relatively stable over the 30-year period. No seasonal difference of the incidence rate was found. Of the 125 Guillain-Barré syndrome cases, 63% were preceded by infection, whereas none were preceded by surgery or malignant disease. Medically treated pain was documented in 70%, mainly confined to the lower extremities.
Pediatric Guillain-Barré syndrome diagnoses in the Danish National Patient Registry have high validity, the incidence peaks at age two years, and is preceded by infection in two-thirds of children. Lower extremity pain is a common clinical presentation in the acute setting. |
doi_str_mv | 10.1016/j.pediatrneurol.2020.01.017 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2381620421</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0887899420300436</els_id><sourcerecordid>2381620421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c383t-beb76c9a2f787333b17de306b7bf5d430fd5a1222fd7c338bb8571104d1ae4013</originalsourceid><addsrcrecordid>eNqNUMtKAzEUDaLYWv0FGXDjZupNMtNkcFWLVqGooC5chUxyB1PaSU1mFD_J7_DHnNIquBMO3M153UPICYUhBTo6mw9XaJ1uQo1t8IshAwZDoB3EDulTKXia0xx2SR-kFKksiqxHDmKcA0BesGyf9DijBZMM-mR8v_FyJpm2brHQrk4vdAhfn8nDR22DX2Li6kQnHNJn1CG51Y3z9buzmEz8iw_NIdmr9CLi0fYOyNPV5ePkOp3dTW8m41lquORNWmIpRqbQrBJdQ85LKixyGJWirHKbcahsriljrLLCcC7LUuaCUsgs1ZgB5QNyuvFdBf_aYmzU0kWDXeUafRsV45KOGGRsTT3fUE3wMQas1Cq4pQ4fioJab6jm6s-Gar2hAtpBdOrjbVBbLtH-an9G6wiXGwJ27745DCoah7XpHAOaRlnv_hX0DaK0igI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2381620421</pqid></control><display><type>article</type><title>Pediatric Guillain-Barré Syndrome in a 30-Year Nationwide Cohort</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Levison, Lotte Sahin ; Thomsen, Reimar Wernich ; Markvardsen, Lars Kjøbsted ; Christensen, Diana Hedevang ; Sindrup, Søren Hein ; Andersen, Henning</creator><creatorcontrib>Levison, Lotte Sahin ; Thomsen, Reimar Wernich ; Markvardsen, Lars Kjøbsted ; Christensen, Diana Hedevang ; Sindrup, Søren Hein ; Andersen, Henning</creatorcontrib><description>Guillain-Barré syndrome is the most common cause of acute flaccid paresis in childhood. Few validated large-scale population-based data are available concerning pediatric Guillain-Barré syndrome, including incidence, risk factors, and initial clinical characteristics.
In the Danish National Patient Registry, we identified all children aged below 16 years (N = 212) diagnosed with Guillain-Barré syndrome and admitted to any Danish department of pediatrics between 1987 and 2016. A total of 145 (68%) medical files could be retrieved and reviewed, enabling classification of patients with true Guillain-Barré syndrome. The nationwide Guillain-Barré syndrome incidence rate was calculated and stratified by age, gender, time periods, and season. Risk factors and initial Guillain-Barré syndrome characteristics were assessed by medical record review.
The positive predictive value of Guillain-Barré syndrome diagnosis codes was 86%. The crude Guillain-Barré syndrome incidence rate was 0.69 per 100,000 person years and peaked at two years of age. The incidence rate was higher among men (0.80) than women (0.58) and was relatively stable over the 30-year period. No seasonal difference of the incidence rate was found. Of the 125 Guillain-Barré syndrome cases, 63% were preceded by infection, whereas none were preceded by surgery or malignant disease. Medically treated pain was documented in 70%, mainly confined to the lower extremities.
Pediatric Guillain-Barré syndrome diagnoses in the Danish National Patient Registry have high validity, the incidence peaks at age two years, and is preceded by infection in two-thirds of children. Lower extremity pain is a common clinical presentation in the acute setting.</description><identifier>ISSN: 0887-8994</identifier><identifier>EISSN: 1873-5150</identifier><identifier>DOI: 10.1016/j.pediatrneurol.2020.01.017</identifier><identifier>PMID: 32192820</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Child ; Child, Preschool ; Cohort Studies ; Female ; GBS characteristics ; GBS epidemiology ; GBS incidence ; GBS risk factors ; GBS validation ; Guillain-Barre Syndrome - diagnosis ; Guillain-Barre Syndrome - epidemiology ; Guillain-Barre Syndrome - etiology ; Guillain-Barre Syndrome - physiopathology ; Humans ; Incidence ; Infant ; Male ; Pediatric GBS ; Registries - statistics & numerical data ; Reproducibility of Results ; Retrospective Studies ; Risk Factors</subject><ispartof>Pediatric neurology, 2020-06, Vol.107, p.57-63</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-beb76c9a2f787333b17de306b7bf5d430fd5a1222fd7c338bb8571104d1ae4013</citedby><cites>FETCH-LOGICAL-c383t-beb76c9a2f787333b17de306b7bf5d430fd5a1222fd7c338bb8571104d1ae4013</cites><orcidid>0000-0002-2210-6020</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pediatrneurol.2020.01.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32192820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levison, Lotte Sahin</creatorcontrib><creatorcontrib>Thomsen, Reimar Wernich</creatorcontrib><creatorcontrib>Markvardsen, Lars Kjøbsted</creatorcontrib><creatorcontrib>Christensen, Diana Hedevang</creatorcontrib><creatorcontrib>Sindrup, Søren Hein</creatorcontrib><creatorcontrib>Andersen, Henning</creatorcontrib><title>Pediatric Guillain-Barré Syndrome in a 30-Year Nationwide Cohort</title><title>Pediatric neurology</title><addtitle>Pediatr Neurol</addtitle><description>Guillain-Barré syndrome is the most common cause of acute flaccid paresis in childhood. Few validated large-scale population-based data are available concerning pediatric Guillain-Barré syndrome, including incidence, risk factors, and initial clinical characteristics.
In the Danish National Patient Registry, we identified all children aged below 16 years (N = 212) diagnosed with Guillain-Barré syndrome and admitted to any Danish department of pediatrics between 1987 and 2016. A total of 145 (68%) medical files could be retrieved and reviewed, enabling classification of patients with true Guillain-Barré syndrome. The nationwide Guillain-Barré syndrome incidence rate was calculated and stratified by age, gender, time periods, and season. Risk factors and initial Guillain-Barré syndrome characteristics were assessed by medical record review.
The positive predictive value of Guillain-Barré syndrome diagnosis codes was 86%. The crude Guillain-Barré syndrome incidence rate was 0.69 per 100,000 person years and peaked at two years of age. The incidence rate was higher among men (0.80) than women (0.58) and was relatively stable over the 30-year period. No seasonal difference of the incidence rate was found. Of the 125 Guillain-Barré syndrome cases, 63% were preceded by infection, whereas none were preceded by surgery or malignant disease. Medically treated pain was documented in 70%, mainly confined to the lower extremities.
Pediatric Guillain-Barré syndrome diagnoses in the Danish National Patient Registry have high validity, the incidence peaks at age two years, and is preceded by infection in two-thirds of children. Lower extremity pain is a common clinical presentation in the acute setting.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>GBS characteristics</subject><subject>GBS epidemiology</subject><subject>GBS incidence</subject><subject>GBS risk factors</subject><subject>GBS validation</subject><subject>Guillain-Barre Syndrome - diagnosis</subject><subject>Guillain-Barre Syndrome - epidemiology</subject><subject>Guillain-Barre Syndrome - etiology</subject><subject>Guillain-Barre Syndrome - physiopathology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Male</subject><subject>Pediatric GBS</subject><subject>Registries - statistics & numerical data</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0887-8994</issn><issn>1873-5150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUMtKAzEUDaLYWv0FGXDjZupNMtNkcFWLVqGooC5chUxyB1PaSU1mFD_J7_DHnNIquBMO3M153UPICYUhBTo6mw9XaJ1uQo1t8IshAwZDoB3EDulTKXia0xx2SR-kFKksiqxHDmKcA0BesGyf9DijBZMM-mR8v_FyJpm2brHQrk4vdAhfn8nDR22DX2Li6kQnHNJn1CG51Y3z9buzmEz8iw_NIdmr9CLi0fYOyNPV5ePkOp3dTW8m41lquORNWmIpRqbQrBJdQ85LKixyGJWirHKbcahsriljrLLCcC7LUuaCUsgs1ZgB5QNyuvFdBf_aYmzU0kWDXeUafRsV45KOGGRsTT3fUE3wMQas1Cq4pQ4fioJab6jm6s-Gar2hAtpBdOrjbVBbLtH-an9G6wiXGwJ27745DCoah7XpHAOaRlnv_hX0DaK0igI</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Levison, Lotte Sahin</creator><creator>Thomsen, Reimar Wernich</creator><creator>Markvardsen, Lars Kjøbsted</creator><creator>Christensen, Diana Hedevang</creator><creator>Sindrup, Søren Hein</creator><creator>Andersen, Henning</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2210-6020</orcidid></search><sort><creationdate>202006</creationdate><title>Pediatric Guillain-Barré Syndrome in a 30-Year Nationwide Cohort</title><author>Levison, Lotte Sahin ; Thomsen, Reimar Wernich ; Markvardsen, Lars Kjøbsted ; Christensen, Diana Hedevang ; Sindrup, Søren Hein ; Andersen, Henning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-beb76c9a2f787333b17de306b7bf5d430fd5a1222fd7c338bb8571104d1ae4013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>GBS characteristics</topic><topic>GBS epidemiology</topic><topic>GBS incidence</topic><topic>GBS risk factors</topic><topic>GBS validation</topic><topic>Guillain-Barre Syndrome - diagnosis</topic><topic>Guillain-Barre Syndrome - epidemiology</topic><topic>Guillain-Barre Syndrome - etiology</topic><topic>Guillain-Barre Syndrome - physiopathology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Male</topic><topic>Pediatric GBS</topic><topic>Registries - statistics & numerical data</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levison, Lotte Sahin</creatorcontrib><creatorcontrib>Thomsen, Reimar Wernich</creatorcontrib><creatorcontrib>Markvardsen, Lars Kjøbsted</creatorcontrib><creatorcontrib>Christensen, Diana Hedevang</creatorcontrib><creatorcontrib>Sindrup, Søren Hein</creatorcontrib><creatorcontrib>Andersen, Henning</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levison, Lotte Sahin</au><au>Thomsen, Reimar Wernich</au><au>Markvardsen, Lars Kjøbsted</au><au>Christensen, Diana Hedevang</au><au>Sindrup, Søren Hein</au><au>Andersen, Henning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pediatric Guillain-Barré Syndrome in a 30-Year Nationwide Cohort</atitle><jtitle>Pediatric neurology</jtitle><addtitle>Pediatr Neurol</addtitle><date>2020-06</date><risdate>2020</risdate><volume>107</volume><spage>57</spage><epage>63</epage><pages>57-63</pages><issn>0887-8994</issn><eissn>1873-5150</eissn><abstract>Guillain-Barré syndrome is the most common cause of acute flaccid paresis in childhood. Few validated large-scale population-based data are available concerning pediatric Guillain-Barré syndrome, including incidence, risk factors, and initial clinical characteristics.
In the Danish National Patient Registry, we identified all children aged below 16 years (N = 212) diagnosed with Guillain-Barré syndrome and admitted to any Danish department of pediatrics between 1987 and 2016. A total of 145 (68%) medical files could be retrieved and reviewed, enabling classification of patients with true Guillain-Barré syndrome. The nationwide Guillain-Barré syndrome incidence rate was calculated and stratified by age, gender, time periods, and season. Risk factors and initial Guillain-Barré syndrome characteristics were assessed by medical record review.
The positive predictive value of Guillain-Barré syndrome diagnosis codes was 86%. The crude Guillain-Barré syndrome incidence rate was 0.69 per 100,000 person years and peaked at two years of age. The incidence rate was higher among men (0.80) than women (0.58) and was relatively stable over the 30-year period. No seasonal difference of the incidence rate was found. Of the 125 Guillain-Barré syndrome cases, 63% were preceded by infection, whereas none were preceded by surgery or malignant disease. Medically treated pain was documented in 70%, mainly confined to the lower extremities.
Pediatric Guillain-Barré syndrome diagnoses in the Danish National Patient Registry have high validity, the incidence peaks at age two years, and is preceded by infection in two-thirds of children. Lower extremity pain is a common clinical presentation in the acute setting.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32192820</pmid><doi>10.1016/j.pediatrneurol.2020.01.017</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2210-6020</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0887-8994 |
ispartof | Pediatric neurology, 2020-06, Vol.107, p.57-63 |
issn | 0887-8994 1873-5150 |
language | eng |
recordid | cdi_proquest_miscellaneous_2381620421 |
source | MEDLINE; Access via ScienceDirect (Elsevier) |
subjects | Adolescent Child Child, Preschool Cohort Studies Female GBS characteristics GBS epidemiology GBS incidence GBS risk factors GBS validation Guillain-Barre Syndrome - diagnosis Guillain-Barre Syndrome - epidemiology Guillain-Barre Syndrome - etiology Guillain-Barre Syndrome - physiopathology Humans Incidence Infant Male Pediatric GBS Registries - statistics & numerical data Reproducibility of Results Retrospective Studies Risk Factors |
title | Pediatric Guillain-Barré Syndrome in a 30-Year Nationwide Cohort |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A54%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pediatric%20Guillain-Barr%C3%A9%20Syndrome%20in%20a%2030-Year%20Nationwide%20Cohort&rft.jtitle=Pediatric%20neurology&rft.au=Levison,%20Lotte%20Sahin&rft.date=2020-06&rft.volume=107&rft.spage=57&rft.epage=63&rft.pages=57-63&rft.issn=0887-8994&rft.eissn=1873-5150&rft_id=info:doi/10.1016/j.pediatrneurol.2020.01.017&rft_dat=%3Cproquest_cross%3E2381620421%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2381620421&rft_id=info:pmid/32192820&rft_els_id=S0887899420300436&rfr_iscdi=true |