Brain Atrophy and the Risk of Futile Endovascular Reperfusion in Acute Ischemic Stroke
BACKGROUND AND PURPOSE—We aimed to evaluate the impact of brain atrophy on long-term clinical outcome in patients with acute ischemic stroke treated with endovascular therapy, and more specifically, to test whether there are interactions between the degree of atrophy and infarct volume, and between...
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| Veröffentlicht in: | Stroke (1970) 2020-05, Vol.51 (5), p.1514-1521 |
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| creator | Pedraza, María I. de Lera, Mercedes Bos, Daniel Calleja, Ana I. Cortijo, Elisa Gómez-Vicente, Beatriz Reyes, Javier Coco-Martín, María Begoña Calonge, Teodoro Agulla, Jesús Martínez-Pías, Enrique Talavera, Blanca Pérez-Fernández, Santiago Schüller, Miguel Galván, Jorge Castaño, Miguel Martínez-Galdámez, Mario Arenillas, Juan F. |
| description | BACKGROUND AND PURPOSE—We aimed to evaluate the impact of brain atrophy on long-term clinical outcome in patients with acute ischemic stroke treated with endovascular therapy, and more specifically, to test whether there are interactions between the degree of atrophy and infarct volume, and between atrophy and age, in determining the risk of futile reperfusion.
METHODS—We studied consecutive patients with acute ischemic stroke with proximal anterior circulation intracranial arterial occlusions treated with endovascular therapy achieving successful arterial recanalization. Brain atrophy was evaluated on baseline computed tomography with the global cortical atrophy scale, and Evans index was calculated to assess subcortical atrophy. Infarct volume was assessed on control computed tomography at 24 hours using the formula for irregular volumes (A×B×C/2). Main outcome variable was futile recanalization, defined by functional dependence (modified Rankin Scale score >2) at 3 months. The predefined interactions of atrophy with age and infarct volume were studied in regression models.
RESULTS—From 361 consecutive patients with anterior circulation acute ischemic stroke treated with endovascular therapy, 295 met all inclusion criteria. Futile reperfusion was observed in 144 out of 295 (48.8%) patients. Cortical atrophy affecting parieto-occipital and temporal regions was associated with futile recanalization. Total global cortical atrophy score and Evans index were independently associated with futile recanalization in an adjusted logistic regression. Multivariable adjusted regression models disclosed significant interactions between global cortical atrophy score and infarct volume (odds ratio, 1.003 [95%CI, 1.002–1.004], P |
| doi_str_mv | 10.1161/STROKEAHA.119.028511 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2379026584</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2379026584</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5641-87dc800b705405b5810f33fb0094c25b49d463fe8f44dcb8676dac7f309f20863</originalsourceid><addsrcrecordid>eNqFkUtL5EAUhYtBGVudfzBILd1Ebz1TteyR9oGC0OpsQ6Vyi8ROJz1VieK_N007LnV1OfCdc-EcQn4zOGNMs_OHx-X97WJ-PZ-kPQNuFGM_yIwpLjOpudkjMwBhMy6tPSCHKT0DABdG_SQHgjNjhDYz8vdPdE1H50PsN_UbdV1Fhxrpskkr2gd6OQ5Ni3TRVf2LS35sXaRL3GAMY2r6jm6tfhyQ3iRf47rx9GFKWuEx2Q-uTfjr4x6Rp8vF48V1dnd_dXMxv8u80pJlJq-8AShzUBJUqQyDIEQoAaz0XJXSVlKLgCZIWfnS6FxXzudBgA0cjBZH5HSXu4n9vxHTUKyb5LFtXYf9mAoucgtcKyMnVO5QH_uUIoZiE5u1i28Fg2LbaPHZ6CRtsWt0sp18fBjLNVafpv8VToDZAa99O2BMq3Z8xVjU6Nqh_i5bfmGd5oJc55Bx4ABqUtl2QS3eAZRhksU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2379026584</pqid></control><display><type>article</type><title>Brain Atrophy and the Risk of Futile Endovascular Reperfusion in Acute Ischemic Stroke</title><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><source>Alma/SFX Local Collection</source><creator>Pedraza, María I. ; de Lera, Mercedes ; Bos, Daniel ; Calleja, Ana I. ; Cortijo, Elisa ; Gómez-Vicente, Beatriz ; Reyes, Javier ; Coco-Martín, María Begoña ; Calonge, Teodoro ; Agulla, Jesús ; Martínez-Pías, Enrique ; Talavera, Blanca ; Pérez-Fernández, Santiago ; Schüller, Miguel ; Galván, Jorge ; Castaño, Miguel ; Martínez-Galdámez, Mario ; Arenillas, Juan F.</creator><creatorcontrib>Pedraza, María I. ; de Lera, Mercedes ; Bos, Daniel ; Calleja, Ana I. ; Cortijo, Elisa ; Gómez-Vicente, Beatriz ; Reyes, Javier ; Coco-Martín, María Begoña ; Calonge, Teodoro ; Agulla, Jesús ; Martínez-Pías, Enrique ; Talavera, Blanca ; Pérez-Fernández, Santiago ; Schüller, Miguel ; Galván, Jorge ; Castaño, Miguel ; Martínez-Galdámez, Mario ; Arenillas, Juan F.</creatorcontrib><description>BACKGROUND AND PURPOSE—We aimed to evaluate the impact of brain atrophy on long-term clinical outcome in patients with acute ischemic stroke treated with endovascular therapy, and more specifically, to test whether there are interactions between the degree of atrophy and infarct volume, and between atrophy and age, in determining the risk of futile reperfusion.
METHODS—We studied consecutive patients with acute ischemic stroke with proximal anterior circulation intracranial arterial occlusions treated with endovascular therapy achieving successful arterial recanalization. Brain atrophy was evaluated on baseline computed tomography with the global cortical atrophy scale, and Evans index was calculated to assess subcortical atrophy. Infarct volume was assessed on control computed tomography at 24 hours using the formula for irregular volumes (A×B×C/2). Main outcome variable was futile recanalization, defined by functional dependence (modified Rankin Scale score >2) at 3 months. The predefined interactions of atrophy with age and infarct volume were studied in regression models.
RESULTS—From 361 consecutive patients with anterior circulation acute ischemic stroke treated with endovascular therapy, 295 met all inclusion criteria. Futile reperfusion was observed in 144 out of 295 (48.8%) patients. Cortical atrophy affecting parieto-occipital and temporal regions was associated with futile recanalization. Total global cortical atrophy score and Evans index were independently associated with futile recanalization in an adjusted logistic regression. Multivariable adjusted regression models disclosed significant interactions between global cortical atrophy score and infarct volume (odds ratio, 1.003 [95%CI, 1.002–1.004], P<0.001) and between global cortical atrophy score and age (odds ratio, 1.001 [95% CI, 1.001–1.002], P<0.001) in determining the risk of futile reperfusion.
CONCLUSIONS—A higher degree of cortical and subcortical brain atrophy is associated with futile endovascular reperfusion in anterior circulation acute ischemic stroke. The impact of brain atrophy on insufficient clinical recovery after endovascular reperfusion appears to be independently amplified by age and by infarct volume.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.119.028511</identifier><identifier>PMID: 32188368</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><ispartof>Stroke (1970), 2020-05, Vol.51 (5), p.1514-1521</ispartof><rights>American Heart Association, Inc.</rights><rights>2020 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5641-87dc800b705405b5810f33fb0094c25b49d463fe8f44dcb8676dac7f309f20863</citedby><cites>FETCH-LOGICAL-c5641-87dc800b705405b5810f33fb0094c25b49d463fe8f44dcb8676dac7f309f20863</cites><orcidid>0000-0002-7780-9268</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3688,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32188368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pedraza, María I.</creatorcontrib><creatorcontrib>de Lera, Mercedes</creatorcontrib><creatorcontrib>Bos, Daniel</creatorcontrib><creatorcontrib>Calleja, Ana I.</creatorcontrib><creatorcontrib>Cortijo, Elisa</creatorcontrib><creatorcontrib>Gómez-Vicente, Beatriz</creatorcontrib><creatorcontrib>Reyes, Javier</creatorcontrib><creatorcontrib>Coco-Martín, María Begoña</creatorcontrib><creatorcontrib>Calonge, Teodoro</creatorcontrib><creatorcontrib>Agulla, Jesús</creatorcontrib><creatorcontrib>Martínez-Pías, Enrique</creatorcontrib><creatorcontrib>Talavera, Blanca</creatorcontrib><creatorcontrib>Pérez-Fernández, Santiago</creatorcontrib><creatorcontrib>Schüller, Miguel</creatorcontrib><creatorcontrib>Galván, Jorge</creatorcontrib><creatorcontrib>Castaño, Miguel</creatorcontrib><creatorcontrib>Martínez-Galdámez, Mario</creatorcontrib><creatorcontrib>Arenillas, Juan F.</creatorcontrib><title>Brain Atrophy and the Risk of Futile Endovascular Reperfusion in Acute Ischemic Stroke</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>BACKGROUND AND PURPOSE—We aimed to evaluate the impact of brain atrophy on long-term clinical outcome in patients with acute ischemic stroke treated with endovascular therapy, and more specifically, to test whether there are interactions between the degree of atrophy and infarct volume, and between atrophy and age, in determining the risk of futile reperfusion.
METHODS—We studied consecutive patients with acute ischemic stroke with proximal anterior circulation intracranial arterial occlusions treated with endovascular therapy achieving successful arterial recanalization. Brain atrophy was evaluated on baseline computed tomography with the global cortical atrophy scale, and Evans index was calculated to assess subcortical atrophy. Infarct volume was assessed on control computed tomography at 24 hours using the formula for irregular volumes (A×B×C/2). Main outcome variable was futile recanalization, defined by functional dependence (modified Rankin Scale score >2) at 3 months. The predefined interactions of atrophy with age and infarct volume were studied in regression models.
RESULTS—From 361 consecutive patients with anterior circulation acute ischemic stroke treated with endovascular therapy, 295 met all inclusion criteria. Futile reperfusion was observed in 144 out of 295 (48.8%) patients. Cortical atrophy affecting parieto-occipital and temporal regions was associated with futile recanalization. Total global cortical atrophy score and Evans index were independently associated with futile recanalization in an adjusted logistic regression. Multivariable adjusted regression models disclosed significant interactions between global cortical atrophy score and infarct volume (odds ratio, 1.003 [95%CI, 1.002–1.004], P<0.001) and between global cortical atrophy score and age (odds ratio, 1.001 [95% CI, 1.001–1.002], P<0.001) in determining the risk of futile reperfusion.
CONCLUSIONS—A higher degree of cortical and subcortical brain atrophy is associated with futile endovascular reperfusion in anterior circulation acute ischemic stroke. The impact of brain atrophy on insufficient clinical recovery after endovascular reperfusion appears to be independently amplified by age and by infarct volume.</description><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkUtL5EAUhYtBGVudfzBILd1Ebz1TteyR9oGC0OpsQ6Vyi8ROJz1VieK_N007LnV1OfCdc-EcQn4zOGNMs_OHx-X97WJ-PZ-kPQNuFGM_yIwpLjOpudkjMwBhMy6tPSCHKT0DABdG_SQHgjNjhDYz8vdPdE1H50PsN_UbdV1Fhxrpskkr2gd6OQ5Ni3TRVf2LS35sXaRL3GAMY2r6jm6tfhyQ3iRf47rx9GFKWuEx2Q-uTfjr4x6Rp8vF48V1dnd_dXMxv8u80pJlJq-8AShzUBJUqQyDIEQoAaz0XJXSVlKLgCZIWfnS6FxXzudBgA0cjBZH5HSXu4n9vxHTUKyb5LFtXYf9mAoucgtcKyMnVO5QH_uUIoZiE5u1i28Fg2LbaPHZ6CRtsWt0sp18fBjLNVafpv8VToDZAa99O2BMq3Z8xVjU6Nqh_i5bfmGd5oJc55Bx4ABqUtl2QS3eAZRhksU</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Pedraza, María I.</creator><creator>de Lera, Mercedes</creator><creator>Bos, Daniel</creator><creator>Calleja, Ana I.</creator><creator>Cortijo, Elisa</creator><creator>Gómez-Vicente, Beatriz</creator><creator>Reyes, Javier</creator><creator>Coco-Martín, María Begoña</creator><creator>Calonge, Teodoro</creator><creator>Agulla, Jesús</creator><creator>Martínez-Pías, Enrique</creator><creator>Talavera, Blanca</creator><creator>Pérez-Fernández, Santiago</creator><creator>Schüller, Miguel</creator><creator>Galván, Jorge</creator><creator>Castaño, Miguel</creator><creator>Martínez-Galdámez, Mario</creator><creator>Arenillas, Juan F.</creator><general>American Heart Association, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7780-9268</orcidid></search><sort><creationdate>20200501</creationdate><title>Brain Atrophy and the Risk of Futile Endovascular Reperfusion in Acute Ischemic Stroke</title><author>Pedraza, María I. ; de Lera, Mercedes ; Bos, Daniel ; Calleja, Ana I. ; Cortijo, Elisa ; Gómez-Vicente, Beatriz ; Reyes, Javier ; Coco-Martín, María Begoña ; Calonge, Teodoro ; Agulla, Jesús ; Martínez-Pías, Enrique ; Talavera, Blanca ; Pérez-Fernández, Santiago ; Schüller, Miguel ; Galván, Jorge ; Castaño, Miguel ; Martínez-Galdámez, Mario ; Arenillas, Juan F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5641-87dc800b705405b5810f33fb0094c25b49d463fe8f44dcb8676dac7f309f20863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pedraza, María I.</creatorcontrib><creatorcontrib>de Lera, Mercedes</creatorcontrib><creatorcontrib>Bos, Daniel</creatorcontrib><creatorcontrib>Calleja, Ana I.</creatorcontrib><creatorcontrib>Cortijo, Elisa</creatorcontrib><creatorcontrib>Gómez-Vicente, Beatriz</creatorcontrib><creatorcontrib>Reyes, Javier</creatorcontrib><creatorcontrib>Coco-Martín, María Begoña</creatorcontrib><creatorcontrib>Calonge, Teodoro</creatorcontrib><creatorcontrib>Agulla, Jesús</creatorcontrib><creatorcontrib>Martínez-Pías, Enrique</creatorcontrib><creatorcontrib>Talavera, Blanca</creatorcontrib><creatorcontrib>Pérez-Fernández, Santiago</creatorcontrib><creatorcontrib>Schüller, Miguel</creatorcontrib><creatorcontrib>Galván, Jorge</creatorcontrib><creatorcontrib>Castaño, Miguel</creatorcontrib><creatorcontrib>Martínez-Galdámez, Mario</creatorcontrib><creatorcontrib>Arenillas, Juan F.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pedraza, María I.</au><au>de Lera, Mercedes</au><au>Bos, Daniel</au><au>Calleja, Ana I.</au><au>Cortijo, Elisa</au><au>Gómez-Vicente, Beatriz</au><au>Reyes, Javier</au><au>Coco-Martín, María Begoña</au><au>Calonge, Teodoro</au><au>Agulla, Jesús</au><au>Martínez-Pías, Enrique</au><au>Talavera, Blanca</au><au>Pérez-Fernández, Santiago</au><au>Schüller, Miguel</au><au>Galván, Jorge</au><au>Castaño, Miguel</au><au>Martínez-Galdámez, Mario</au><au>Arenillas, Juan F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain Atrophy and the Risk of Futile Endovascular Reperfusion in Acute Ischemic Stroke</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>51</volume><issue>5</issue><spage>1514</spage><epage>1521</epage><pages>1514-1521</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><abstract>BACKGROUND AND PURPOSE—We aimed to evaluate the impact of brain atrophy on long-term clinical outcome in patients with acute ischemic stroke treated with endovascular therapy, and more specifically, to test whether there are interactions between the degree of atrophy and infarct volume, and between atrophy and age, in determining the risk of futile reperfusion.
METHODS—We studied consecutive patients with acute ischemic stroke with proximal anterior circulation intracranial arterial occlusions treated with endovascular therapy achieving successful arterial recanalization. Brain atrophy was evaluated on baseline computed tomography with the global cortical atrophy scale, and Evans index was calculated to assess subcortical atrophy. Infarct volume was assessed on control computed tomography at 24 hours using the formula for irregular volumes (A×B×C/2). Main outcome variable was futile recanalization, defined by functional dependence (modified Rankin Scale score >2) at 3 months. The predefined interactions of atrophy with age and infarct volume were studied in regression models.
RESULTS—From 361 consecutive patients with anterior circulation acute ischemic stroke treated with endovascular therapy, 295 met all inclusion criteria. Futile reperfusion was observed in 144 out of 295 (48.8%) patients. Cortical atrophy affecting parieto-occipital and temporal regions was associated with futile recanalization. Total global cortical atrophy score and Evans index were independently associated with futile recanalization in an adjusted logistic regression. Multivariable adjusted regression models disclosed significant interactions between global cortical atrophy score and infarct volume (odds ratio, 1.003 [95%CI, 1.002–1.004], P<0.001) and between global cortical atrophy score and age (odds ratio, 1.001 [95% CI, 1.001–1.002], P<0.001) in determining the risk of futile reperfusion.
CONCLUSIONS—A higher degree of cortical and subcortical brain atrophy is associated with futile endovascular reperfusion in anterior circulation acute ischemic stroke. The impact of brain atrophy on insufficient clinical recovery after endovascular reperfusion appears to be independently amplified by age and by infarct volume.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>32188368</pmid><doi>10.1161/STROKEAHA.119.028511</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7780-9268</orcidid><oa>free_for_read</oa></addata></record> |
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| title | Brain Atrophy and the Risk of Futile Endovascular Reperfusion in Acute Ischemic Stroke |
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