Magnetic molecularly imprinted specific solid‐phase extraction for determination of dihydroquercetin from Larix griffithiana using HPLC
The naturally occurring quercetin flavonoid, dihydroquercetin, is widely distributed in plant tissues and has a variety of biological activities. Herein, a magnetic molecularly imprinted solid‐phase extraction was tailor made for selective determination of dihydroquercetin in Larix griffithiana usin...
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| Veröffentlicht in: | Journal of separation science 2020-06, Vol.43 (12), p.2301-2310 |
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| container_title | Journal of separation science |
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| creator | Ma, Xingbin Zhang, Xukun Lin, Hongling Abd El‐Aty, A. M. Rabah, Tsdan Liu, Xiaoxi Yu, Zhichao Yong, Yanhong Ju, Xianghong She, Yongxin |
| description | The naturally occurring quercetin flavonoid, dihydroquercetin, is widely distributed in plant tissues and has a variety of biological activities. Herein, a magnetic molecularly imprinted solid‐phase extraction was tailor made for selective determination of dihydroquercetin in Larix griffithiana using high‐performance liquid chromatography. Amino‐functionalized core‐shell magnetic nanoparticles were prepared and characterized using scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, and infrared spectroscopy. The polymer had an average diameter of 250 ± 2.56 nm and exhibited good stability and adsorption for template molecule, which is enriched by hydrogen bonding interaction. Multiple factors for extraction, including loading, washing, elution solvents, and extraction time, were optimized. The limit of detection was 1.23 μg/g. The precision determined at various concentration of dihydroquercetin was less than 4% and the mean recovery was between 74.64 and 101.80%. It has therefore been shown that this protocol can be used as an alternative extraction to quantify dihydroquercetin in L. griffithiana and purify quercetin flavonoid from other complex matrices. |
| doi_str_mv | 10.1002/jssc.201901086 |
| format | Article |
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The polymer had an average diameter of 250 ± 2.56 nm and exhibited good stability and adsorption for template molecule, which is enriched by hydrogen bonding interaction. Multiple factors for extraction, including loading, washing, elution solvents, and extraction time, were optimized. The limit of detection was 1.23 μg/g. The precision determined at various concentration of dihydroquercetin was less than 4% and the mean recovery was between 74.64 and 101.80%. It has therefore been shown that this protocol can be used as an alternative extraction to quantify dihydroquercetin in L. griffithiana and purify quercetin flavonoid from other complex matrices.</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.201901086</identifier><identifier>PMID: 32191398</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Chromatography, High Pressure Liquid ; dihydroquercetin ; Electron microscopy ; Elution ; Flavonoids ; High performance liquid chromatography ; Hydrogen bonding ; Larix - chemistry ; Larix griffithiana ; Magnetic measurement ; Magnetic Phenomena ; magnetic separation ; Microscopy ; Molecular Imprinting ; molecularly imprinted polymers ; Nanoparticles ; Quercetin - analogs & derivatives ; Quercetin - analysis ; Solid Phase Extraction ; Tibetan medicine</subject><ispartof>Journal of separation science, 2020-06, Vol.43 (12), p.2301-2310</ispartof><rights>2020 WILEY‐VCH Verlag GmbH & Co. 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KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4052-db08722be1212eff893ee8d52e69ec2a762896373ba740a654a7c9c7d5bf27b53</citedby><cites>FETCH-LOGICAL-c4052-db08722be1212eff893ee8d52e69ec2a762896373ba740a654a7c9c7d5bf27b53</cites><orcidid>0000-0003-2874-8312 ; 0000-0001-6596-7907</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjssc.201901086$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjssc.201901086$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32191398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Xingbin</creatorcontrib><creatorcontrib>Zhang, Xukun</creatorcontrib><creatorcontrib>Lin, Hongling</creatorcontrib><creatorcontrib>Abd El‐Aty, A. 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Amino‐functionalized core‐shell magnetic nanoparticles were prepared and characterized using scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, and infrared spectroscopy. The polymer had an average diameter of 250 ± 2.56 nm and exhibited good stability and adsorption for template molecule, which is enriched by hydrogen bonding interaction. Multiple factors for extraction, including loading, washing, elution solvents, and extraction time, were optimized. The limit of detection was 1.23 μg/g. The precision determined at various concentration of dihydroquercetin was less than 4% and the mean recovery was between 74.64 and 101.80%. It has therefore been shown that this protocol can be used as an alternative extraction to quantify dihydroquercetin in L. griffithiana and purify quercetin flavonoid from other complex matrices.</description><subject>Chromatography, High Pressure Liquid</subject><subject>dihydroquercetin</subject><subject>Electron microscopy</subject><subject>Elution</subject><subject>Flavonoids</subject><subject>High performance liquid chromatography</subject><subject>Hydrogen bonding</subject><subject>Larix - chemistry</subject><subject>Larix griffithiana</subject><subject>Magnetic measurement</subject><subject>Magnetic Phenomena</subject><subject>magnetic separation</subject><subject>Microscopy</subject><subject>Molecular Imprinting</subject><subject>molecularly imprinted polymers</subject><subject>Nanoparticles</subject><subject>Quercetin - analogs & derivatives</subject><subject>Quercetin - analysis</subject><subject>Solid Phase Extraction</subject><subject>Tibetan medicine</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT9vEzEYhy0EoqWwMiJLLCwJ_nf2eURRaUGpilSYLZ_9OnF0dw72nWg21m58Rj4Jl6bNwNLptV4_fvSTfwi9pWROCWEfN6W4OSNUE0pq-QydUkmrmeZUPD-eiTxBr0rZEEJVrclLdMIZ1ZTr-hTdXdlVD0N0uEstuLG1ud3h2G1z7AfwuGzBxTBdl9RG__f3n-3aFsBwO2Trhph6HFLGHgbIXezt_SYF7ON653P6OUJ2k32icurw0uZ4i1c5hhCHdbS9xWOJ_QpfflsuXqMXwbYF3jzMM_Tj8_n3xeVseX3xZfFpOXOCVGzmG1IrxhqgjDIIodYcoPYVA6nBMaskq7XkijdWCWJlJaxy2ilfNYGppuJn6MPBu73PVwbTxeKgbW0PaSyGcaUJo0KqCX3_H7pJY-6ndIYJKhjlUuyF8wPlciolQzDT53U27wwlZl-S2ZdkjiVND949aMemA3_EH1uZAHEAfsUWdk_ozNebm4WsGeP_ALcHoPw</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Ma, Xingbin</creator><creator>Zhang, Xukun</creator><creator>Lin, Hongling</creator><creator>Abd El‐Aty, A. 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M. ; Rabah, Tsdan ; Liu, Xiaoxi ; Yu, Zhichao ; Yong, Yanhong ; Ju, Xianghong ; She, Yongxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4052-db08722be1212eff893ee8d52e69ec2a762896373ba740a654a7c9c7d5bf27b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Chromatography, High Pressure Liquid</topic><topic>dihydroquercetin</topic><topic>Electron microscopy</topic><topic>Elution</topic><topic>Flavonoids</topic><topic>High performance liquid chromatography</topic><topic>Hydrogen bonding</topic><topic>Larix - chemistry</topic><topic>Larix griffithiana</topic><topic>Magnetic measurement</topic><topic>Magnetic Phenomena</topic><topic>magnetic separation</topic><topic>Microscopy</topic><topic>Molecular Imprinting</topic><topic>molecularly imprinted polymers</topic><topic>Nanoparticles</topic><topic>Quercetin - analogs & derivatives</topic><topic>Quercetin - analysis</topic><topic>Solid Phase Extraction</topic><topic>Tibetan medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Xingbin</creatorcontrib><creatorcontrib>Zhang, Xukun</creatorcontrib><creatorcontrib>Lin, Hongling</creatorcontrib><creatorcontrib>Abd El‐Aty, A. M.</creatorcontrib><creatorcontrib>Rabah, Tsdan</creatorcontrib><creatorcontrib>Liu, Xiaoxi</creatorcontrib><creatorcontrib>Yu, Zhichao</creatorcontrib><creatorcontrib>Yong, Yanhong</creatorcontrib><creatorcontrib>Ju, Xianghong</creatorcontrib><creatorcontrib>She, Yongxin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Xingbin</au><au>Zhang, Xukun</au><au>Lin, Hongling</au><au>Abd El‐Aty, A. M.</au><au>Rabah, Tsdan</au><au>Liu, Xiaoxi</au><au>Yu, Zhichao</au><au>Yong, Yanhong</au><au>Ju, Xianghong</au><au>She, Yongxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic molecularly imprinted specific solid‐phase extraction for determination of dihydroquercetin from Larix griffithiana using HPLC</atitle><jtitle>Journal of separation science</jtitle><addtitle>J Sep Sci</addtitle><date>2020-06</date><risdate>2020</risdate><volume>43</volume><issue>12</issue><spage>2301</spage><epage>2310</epage><pages>2301-2310</pages><issn>1615-9306</issn><eissn>1615-9314</eissn><abstract>The naturally occurring quercetin flavonoid, dihydroquercetin, is widely distributed in plant tissues and has a variety of biological activities. Herein, a magnetic molecularly imprinted solid‐phase extraction was tailor made for selective determination of dihydroquercetin in Larix griffithiana using high‐performance liquid chromatography. Amino‐functionalized core‐shell magnetic nanoparticles were prepared and characterized using scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, and infrared spectroscopy. The polymer had an average diameter of 250 ± 2.56 nm and exhibited good stability and adsorption for template molecule, which is enriched by hydrogen bonding interaction. Multiple factors for extraction, including loading, washing, elution solvents, and extraction time, were optimized. The limit of detection was 1.23 μg/g. The precision determined at various concentration of dihydroquercetin was less than 4% and the mean recovery was between 74.64 and 101.80%. It has therefore been shown that this protocol can be used as an alternative extraction to quantify dihydroquercetin in L. griffithiana and purify quercetin flavonoid from other complex matrices.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32191398</pmid><doi>10.1002/jssc.201901086</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2874-8312</orcidid><orcidid>https://orcid.org/0000-0001-6596-7907</orcidid></addata></record> |
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| subjects | Chromatography, High Pressure Liquid dihydroquercetin Electron microscopy Elution Flavonoids High performance liquid chromatography Hydrogen bonding Larix - chemistry Larix griffithiana Magnetic measurement Magnetic Phenomena magnetic separation Microscopy Molecular Imprinting molecularly imprinted polymers Nanoparticles Quercetin - analogs & derivatives Quercetin - analysis Solid Phase Extraction Tibetan medicine |
| title | Magnetic molecularly imprinted specific solid‐phase extraction for determination of dihydroquercetin from Larix griffithiana using HPLC |
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