Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-c][1,2,4]triazolo[3,4-f][1,2,4]triazines

A series of 34 new pyrimido[2,1-c][1,2,4]triazine-3,4-diones were synthesized and fully characterized using IR, NMR, MS, and microanalytical analysis. In vitro investigation of 12 compounds of this series revealed promising antimicrobial activity of the conjugates 15a and 15f-j that were tagged with...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2020-03, Vol.25 (6), p.1339, Article 1339
Hauptverfasser:	El Azab, Islam H., Elkanzi, Nadia A. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,4-triazine 1,2,4-triazole Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Bacteria - drug effects Biochemistry & Molecular Biology Chemistry Chemistry, Multidisciplinary Drugs Fungi - drug effects Life Sciences & Biomedicine mannich reaction Microbial Sensitivity Tests - methods Mutation n-heterocycles NMR Nuclear magnetic resonance Physical Sciences Pseudomonas aeruginosa pyrimidine Science & Technology Triazine Triazines - chemical synthesis Triazines - pharmacology Triazoles - chemical synthesis Triazoles - pharmacology
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