Humoral response to a 13-valent pneumococcal conjugate vaccine in kidney transplant recipients
Vaccination against S. pneumoniae is recommended by national guidelines. Moderate immunogenicity of the 13-valent pneumococcal conjugate vaccine (PCV13) has been reported in adult kidney transplant recipients (KTR). This study further defines the immunogenicity of PCV13 in this cohort. 49 KTR were i...
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| Veröffentlicht in: | Vaccine 2020-04, Vol.38 (17), p.3339-3350 |
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| creator | Oesterreich, Simon Lindemann, Monika Goldblatt, David Horn, Peter A. Wilde, Benjamin Witzke, Oliver |
| description | Vaccination against S. pneumoniae is recommended by national guidelines. Moderate immunogenicity of the 13-valent pneumococcal conjugate vaccine (PCV13) has been reported in adult kidney transplant recipients (KTR). This study further defines the immunogenicity of PCV13 in this cohort.
49 KTR were immunized with PCV13. A validated opsonophagocytic killing assay (OPA), a global anti-pneumococcal capsular polysaccharide (anti-PCP) IgG, IgG2, IgM and IgA ELISA, and - for selected patients - a serotype specific anti-PCP WHO reference ELISA were performed pre-vaccination and at month 1 and 12 post-vaccination.
Geometric mean OPA titers increased significantly for 13/13 serotypes at month 1 and for 10/13 serotypes at month 12 post-vaccination. Vaccine response defined as an OPA titer ≥1:8 was reached in 9/13 serotypes (median). 53% reached the vaccine response criteria at month 1 and 45% at month 12. At month 1 after vaccination, the median OPA titer in an age-group matched healthy reference population was 5- to 10-fold higher than in KTR. OPA titers correlated strongly with results to the global and serotype specific anti-PCP IgG ELISA. Lower OPA titers significantly (p |
| doi_str_mv | 10.1016/j.vaccine.2020.02.088 |
| format | Article |
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49 KTR were immunized with PCV13. A validated opsonophagocytic killing assay (OPA), a global anti-pneumococcal capsular polysaccharide (anti-PCP) IgG, IgG2, IgM and IgA ELISA, and - for selected patients - a serotype specific anti-PCP WHO reference ELISA were performed pre-vaccination and at month 1 and 12 post-vaccination.
Geometric mean OPA titers increased significantly for 13/13 serotypes at month 1 and for 10/13 serotypes at month 12 post-vaccination. Vaccine response defined as an OPA titer ≥1:8 was reached in 9/13 serotypes (median). 53% reached the vaccine response criteria at month 1 and 45% at month 12. At month 1 after vaccination, the median OPA titer in an age-group matched healthy reference population was 5- to 10-fold higher than in KTR. OPA titers correlated strongly with results to the global and serotype specific anti-PCP IgG ELISA. Lower OPA titers significantly (p < 0.05) correlated with albuminuria, an interval between vaccination and transplantation <12 months, age and treatment with mycophenolate mofetil. Global IgG, IgG2, IgM and IgA, as well as serotype specific anti-PCP antibody concentrations (12/13 serotypes) increased significantly at month 1 and 12 post-vaccination.
Kidney transplant recipients show a significant humoral response after vaccination with PCV13. Functional antibody response exists, but is not as vigorous as in healthy adults.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2020.02.088</identifier><identifier>PMID: 32178906</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Adults ; Age ; Antibodies ; Antibodies, Bacterial - blood ; Antibody response ; Binding sites ; Blood & organ donations ; Capsular polysaccharides ; Conjugates ; Enzyme-linked immunosorbent assay ; Humans ; Immune response (humoral) ; Immunity, Humoral ; Immunization ; Immunogenicity ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Kidney transplant recipients ; Kidney Transplantation ; Kidney transplants ; Kidneys ; Laboratories ; Mycophenolate mofetil ; Mycophenolic acid ; Opsonophagocytic assay ; Pneumococcal antibody global serum assays ; Pneumococcal conjugate vaccine ; Pneumococcal Infections - prevention & control ; Pneumococcal vaccination in immunocompromised individuals ; Pneumococcal Vaccines - immunology ; Polysaccharides ; Population ; Serogroup ; Serotype specific ; Serotypes ; Streptococcus infections ; Streptococcus pneumoniae - classification ; Transplant Recipients ; Transplantation ; Vaccination ; Vaccines ; Vaccines, Conjugate - immunology</subject><ispartof>Vaccine, 2020-04, Vol.38 (17), p.3339-3350</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>2020. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-db7fd16861937c245f835412e72f18065387029a2427bd49363992606857e6cc3</citedby><cites>FETCH-LOGICAL-c440t-db7fd16861937c245f835412e72f18065387029a2427bd49363992606857e6cc3</cites><orcidid>0000-0001-6708-4390 ; 0000-0002-0769-5242</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2425692723?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32178906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oesterreich, Simon</creatorcontrib><creatorcontrib>Lindemann, Monika</creatorcontrib><creatorcontrib>Goldblatt, David</creatorcontrib><creatorcontrib>Horn, Peter A.</creatorcontrib><creatorcontrib>Wilde, Benjamin</creatorcontrib><creatorcontrib>Witzke, Oliver</creatorcontrib><title>Humoral response to a 13-valent pneumococcal conjugate vaccine in kidney transplant recipients</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Vaccination against S. pneumoniae is recommended by national guidelines. Moderate immunogenicity of the 13-valent pneumococcal conjugate vaccine (PCV13) has been reported in adult kidney transplant recipients (KTR). This study further defines the immunogenicity of PCV13 in this cohort.
49 KTR were immunized with PCV13. A validated opsonophagocytic killing assay (OPA), a global anti-pneumococcal capsular polysaccharide (anti-PCP) IgG, IgG2, IgM and IgA ELISA, and - for selected patients - a serotype specific anti-PCP WHO reference ELISA were performed pre-vaccination and at month 1 and 12 post-vaccination.
Geometric mean OPA titers increased significantly for 13/13 serotypes at month 1 and for 10/13 serotypes at month 12 post-vaccination. Vaccine response defined as an OPA titer ≥1:8 was reached in 9/13 serotypes (median). 53% reached the vaccine response criteria at month 1 and 45% at month 12. At month 1 after vaccination, the median OPA titer in an age-group matched healthy reference population was 5- to 10-fold higher than in KTR. OPA titers correlated strongly with results to the global and serotype specific anti-PCP IgG ELISA. Lower OPA titers significantly (p < 0.05) correlated with albuminuria, an interval between vaccination and transplantation <12 months, age and treatment with mycophenolate mofetil. Global IgG, IgG2, IgM and IgA, as well as serotype specific anti-PCP antibody concentrations (12/13 serotypes) increased significantly at month 1 and 12 post-vaccination.
Kidney transplant recipients show a significant humoral response after vaccination with PCV13. Functional antibody response exists, but is not as vigorous as in healthy adults.</description><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibody response</subject><subject>Binding sites</subject><subject>Blood & organ donations</subject><subject>Capsular polysaccharides</subject><subject>Conjugates</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Humans</subject><subject>Immune response (humoral)</subject><subject>Immunity, Humoral</subject><subject>Immunization</subject><subject>Immunogenicity</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Kidney transplant recipients</subject><subject>Kidney Transplantation</subject><subject>Kidney transplants</subject><subject>Kidneys</subject><subject>Laboratories</subject><subject>Mycophenolate mofetil</subject><subject>Mycophenolic acid</subject><subject>Opsonophagocytic assay</subject><subject>Pneumococcal antibody global serum assays</subject><subject>Pneumococcal conjugate vaccine</subject><subject>Pneumococcal Infections - 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Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oesterreich, Simon</au><au>Lindemann, Monika</au><au>Goldblatt, David</au><au>Horn, Peter A.</au><au>Wilde, Benjamin</au><au>Witzke, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Humoral response to a 13-valent pneumococcal conjugate vaccine in kidney transplant recipients</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2020-04-09</date><risdate>2020</risdate><volume>38</volume><issue>17</issue><spage>3339</spage><epage>3350</epage><pages>3339-3350</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Vaccination against S. pneumoniae is recommended by national guidelines. Moderate immunogenicity of the 13-valent pneumococcal conjugate vaccine (PCV13) has been reported in adult kidney transplant recipients (KTR). This study further defines the immunogenicity of PCV13 in this cohort.
49 KTR were immunized with PCV13. A validated opsonophagocytic killing assay (OPA), a global anti-pneumococcal capsular polysaccharide (anti-PCP) IgG, IgG2, IgM and IgA ELISA, and - for selected patients - a serotype specific anti-PCP WHO reference ELISA were performed pre-vaccination and at month 1 and 12 post-vaccination.
Geometric mean OPA titers increased significantly for 13/13 serotypes at month 1 and for 10/13 serotypes at month 12 post-vaccination. Vaccine response defined as an OPA titer ≥1:8 was reached in 9/13 serotypes (median). 53% reached the vaccine response criteria at month 1 and 45% at month 12. At month 1 after vaccination, the median OPA titer in an age-group matched healthy reference population was 5- to 10-fold higher than in KTR. OPA titers correlated strongly with results to the global and serotype specific anti-PCP IgG ELISA. Lower OPA titers significantly (p < 0.05) correlated with albuminuria, an interval between vaccination and transplantation <12 months, age and treatment with mycophenolate mofetil. Global IgG, IgG2, IgM and IgA, as well as serotype specific anti-PCP antibody concentrations (12/13 serotypes) increased significantly at month 1 and 12 post-vaccination.
Kidney transplant recipients show a significant humoral response after vaccination with PCV13. Functional antibody response exists, but is not as vigorous as in healthy adults.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>32178906</pmid><doi>10.1016/j.vaccine.2020.02.088</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6708-4390</orcidid><orcidid>https://orcid.org/0000-0002-0769-5242</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adults Age Antibodies Antibodies, Bacterial - blood Antibody response Binding sites Blood & organ donations Capsular polysaccharides Conjugates Enzyme-linked immunosorbent assay Humans Immune response (humoral) Immunity, Humoral Immunization Immunogenicity Immunoglobulin A Immunoglobulin G Immunoglobulin M Kidney transplant recipients Kidney Transplantation Kidney transplants Kidneys Laboratories Mycophenolate mofetil Mycophenolic acid Opsonophagocytic assay Pneumococcal antibody global serum assays Pneumococcal conjugate vaccine Pneumococcal Infections - prevention & control Pneumococcal vaccination in immunocompromised individuals Pneumococcal Vaccines - immunology Polysaccharides Population Serogroup Serotype specific Serotypes Streptococcus infections Streptococcus pneumoniae - classification Transplant Recipients Transplantation Vaccination Vaccines Vaccines, Conjugate - immunology |
| title | Humoral response to a 13-valent pneumococcal conjugate vaccine in kidney transplant recipients |
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