A large multicenter cohort on the use of full-thickness resection device for difficult colonic lesions
Background Introduction of the full-thickness resection device (FTRD) has allowed endoscopic resection of difficult lesions such as those with deep wall origin/infiltration or those located in difficult anatomic locations. The aim of this study is to assess the outcomes of the FTRD among its early u...
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| Veröffentlicht in: | Surgical endoscopy 2021-03, Vol.35 (3), p.1296-1306 |
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| creator | Ichkhanian, Y. Vosoughi, K. Diehl, D. L. Grimm, I. S. James, T. W. Templeton, A. W. Hajifathalian, K. Tokar, J. L. Samarasena, J. B. Chehade, N. El Hage Lee, J. Chang, K. Mizrahi, M. Barawi, M. Irani, S. Friedland, S. Korc, P. Aadam, A. A. Al-Haddad, M. A. Kowalski, T. E. Novikov, A. Smallfield, G. Ginsberg, G. G. Oza, V. M. Panuu, D. Fukami, N. Pohl, H. Lajin, Michael Kumta, N. A. Tang, S. J. Naga, Y. M. Amateau, S. K. Brewer, G. O. I. Kumbhari, V. Sharaiha, R. Khashab, Mouen A. |
| description | Background
Introduction of the full-thickness resection device (FTRD) has allowed endoscopic resection of difficult lesions such as those with deep wall origin/infiltration or those located in difficult anatomic locations. The aim of this study is to assess the outcomes of the FTRD among its early users in the USA.
Methods
Patients who underwent endoscopic full-thickness resection (EFTR) for lower gastrointestinal tract lesions using the FTRD at 26 US tertiary care centers between 10/2017 and 12/2018 were included. Primary outcome was R0 resection rate. Secondary outcomes included rate of technical success (en bloc resection), achievement of histologic full-thickness resection (FTR), and adverse events (AE).
Results
A total of 95 patients (mean age 65.5 ± 12.6 year, 38.9% F) were included. The most common indication, for use of FTRD, was resection of difficult adenomas (non-lifting, recurrent, residual, or involving appendiceal orifice/diverticular opening) (66.3%), followed by adenocarcinomas (22.1%), and subepithelial tumors (SET) (11.6%). Lesions were located in the proximal colon (61.1%), distal colon (18.9%), or rectum (20%). Mean lesion diameter was 15.5 ± 6.4 mm and 61.1% had a prior resection attempt. The mean total procedure time was 59.7 ± 31.8 min. R0 resection was achieved in 82.7% while technical success was achieved in 84.2%. Histologically FTR was demonstrated in 88.1% of patients. There were five clinical AE (5.3%) with 2 (2.1%) requiring surgical intervention.
Conclusions
Results from this first US multicenter study suggest that EFTR with the FTRD is a technically feasible, safe, and effective technique for resecting difficult colonic lesions. |
| doi_str_mv | 10.1007/s00464-020-07504-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2378001923</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2489908613</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-86ac0b87db7ec835274860f75d65d94641f92fdaf0ced71b2dbeb1a0b1aa43943</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS1ERS-FF2CBLLHpxnT8kzheVhUUpEpsYG0l9rg3xTcudoLE2zPlFpBYsLAsa75zZsaHsVcS3koAe9EATG8EKBBgOzDCPWE7abQSSsnhKduB0yCUdeaUPW_tDoh3snvGTjXV6SV3LF3yPNZb5Ictr3PAZcXKQ9mXuvKy8HWPfGvIS-Jpy1ms-zl8XbA1XrFhWGdiIn4nIU-l8jinNAdyIotcljnwjI2Y9oKdpDE3fPl4n7Ev7999vvogbj5df7y6vBHBGLmKoR8DTIONk8Uw6E5ZM_SQbBf7LjpaVianUhwTBIxWTipOOMkR6IxGO6PP2PnR976Wbxu21R_mFjDnccGyNa-0pcWlU5rQN_-gd2WrC03nlRmcg6GXD5Q6UqGW1iomf1_nw1h_eAn-IQV_TMFTCv5XCt6R6PWj9TYdMP6R_P52AvQRaFRabrH-7f0f258VfZLs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2489908613</pqid></control><display><type>article</type><title>A large multicenter cohort on the use of full-thickness resection device for difficult colonic lesions</title><source>SpringerLink Journals - AutoHoldings</source><creator>Ichkhanian, Y. ; Vosoughi, K. ; Diehl, D. L. ; Grimm, I. S. ; James, T. W. ; Templeton, A. W. ; Hajifathalian, K. ; Tokar, J. L. ; Samarasena, J. B. ; Chehade, N. El Hage ; Lee, J. ; Chang, K. ; Mizrahi, M. ; Barawi, M. ; Irani, S. ; Friedland, S. ; Korc, P. ; Aadam, A. A. ; Al-Haddad, M. A. ; Kowalski, T. E. ; Novikov, A. ; Smallfield, G. ; Ginsberg, G. G. ; Oza, V. M. ; Panuu, D. ; Fukami, N. ; Pohl, H. ; Lajin, Michael ; Kumta, N. A. ; Tang, S. J. ; Naga, Y. M. ; Amateau, S. K. ; Brewer, G. O. I. ; Kumbhari, V. ; Sharaiha, R. ; Khashab, Mouen A.</creator><creatorcontrib>Ichkhanian, Y. ; Vosoughi, K. ; Diehl, D. L. ; Grimm, I. S. ; James, T. W. ; Templeton, A. W. ; Hajifathalian, K. ; Tokar, J. L. ; Samarasena, J. B. ; Chehade, N. El Hage ; Lee, J. ; Chang, K. ; Mizrahi, M. ; Barawi, M. ; Irani, S. ; Friedland, S. ; Korc, P. ; Aadam, A. A. ; Al-Haddad, M. A. ; Kowalski, T. E. ; Novikov, A. ; Smallfield, G. ; Ginsberg, G. G. ; Oza, V. M. ; Panuu, D. ; Fukami, N. ; Pohl, H. ; Lajin, Michael ; Kumta, N. A. ; Tang, S. J. ; Naga, Y. M. ; Amateau, S. K. ; Brewer, G. O. I. ; Kumbhari, V. ; Sharaiha, R. ; Khashab, Mouen A.</creatorcontrib><description>Background
Introduction of the full-thickness resection device (FTRD) has allowed endoscopic resection of difficult lesions such as those with deep wall origin/infiltration or those located in difficult anatomic locations. The aim of this study is to assess the outcomes of the FTRD among its early users in the USA.
Methods
Patients who underwent endoscopic full-thickness resection (EFTR) for lower gastrointestinal tract lesions using the FTRD at 26 US tertiary care centers between 10/2017 and 12/2018 were included. Primary outcome was R0 resection rate. Secondary outcomes included rate of technical success (en bloc resection), achievement of histologic full-thickness resection (FTR), and adverse events (AE).
Results
A total of 95 patients (mean age 65.5 ± 12.6 year, 38.9% F) were included. The most common indication, for use of FTRD, was resection of difficult adenomas (non-lifting, recurrent, residual, or involving appendiceal orifice/diverticular opening) (66.3%), followed by adenocarcinomas (22.1%), and subepithelial tumors (SET) (11.6%). Lesions were located in the proximal colon (61.1%), distal colon (18.9%), or rectum (20%). Mean lesion diameter was 15.5 ± 6.4 mm and 61.1% had a prior resection attempt. The mean total procedure time was 59.7 ± 31.8 min. R0 resection was achieved in 82.7% while technical success was achieved in 84.2%. Histologically FTR was demonstrated in 88.1% of patients. There were five clinical AE (5.3%) with 2 (2.1%) requiring surgical intervention.
Conclusions
Results from this first US multicenter study suggest that EFTR with the FTRD is a technically feasible, safe, and effective technique for resecting difficult colonic lesions.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-020-07504-9</identifier><identifier>PMID: 32180001</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abdominal Surgery ; Colon ; Colonoscopy ; Endoscopy ; Gastroenterology ; Gynecology ; Hepatology ; Medicine ; Medicine & Public Health ; Polyps ; Proctology ; Success ; Surgery ; Tumors</subject><ispartof>Surgical endoscopy, 2021-03, Vol.35 (3), p.1296-1306</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-86ac0b87db7ec835274860f75d65d94641f92fdaf0ced71b2dbeb1a0b1aa43943</citedby><cites>FETCH-LOGICAL-c441t-86ac0b87db7ec835274860f75d65d94641f92fdaf0ced71b2dbeb1a0b1aa43943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00464-020-07504-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00464-020-07504-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32180001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ichkhanian, Y.</creatorcontrib><creatorcontrib>Vosoughi, K.</creatorcontrib><creatorcontrib>Diehl, D. L.</creatorcontrib><creatorcontrib>Grimm, I. S.</creatorcontrib><creatorcontrib>James, T. W.</creatorcontrib><creatorcontrib>Templeton, A. W.</creatorcontrib><creatorcontrib>Hajifathalian, K.</creatorcontrib><creatorcontrib>Tokar, J. L.</creatorcontrib><creatorcontrib>Samarasena, J. B.</creatorcontrib><creatorcontrib>Chehade, N. El Hage</creatorcontrib><creatorcontrib>Lee, J.</creatorcontrib><creatorcontrib>Chang, K.</creatorcontrib><creatorcontrib>Mizrahi, M.</creatorcontrib><creatorcontrib>Barawi, M.</creatorcontrib><creatorcontrib>Irani, S.</creatorcontrib><creatorcontrib>Friedland, S.</creatorcontrib><creatorcontrib>Korc, P.</creatorcontrib><creatorcontrib>Aadam, A. A.</creatorcontrib><creatorcontrib>Al-Haddad, M. A.</creatorcontrib><creatorcontrib>Kowalski, T. E.</creatorcontrib><creatorcontrib>Novikov, A.</creatorcontrib><creatorcontrib>Smallfield, G.</creatorcontrib><creatorcontrib>Ginsberg, G. G.</creatorcontrib><creatorcontrib>Oza, V. M.</creatorcontrib><creatorcontrib>Panuu, D.</creatorcontrib><creatorcontrib>Fukami, N.</creatorcontrib><creatorcontrib>Pohl, H.</creatorcontrib><creatorcontrib>Lajin, Michael</creatorcontrib><creatorcontrib>Kumta, N. A.</creatorcontrib><creatorcontrib>Tang, S. J.</creatorcontrib><creatorcontrib>Naga, Y. M.</creatorcontrib><creatorcontrib>Amateau, S. K.</creatorcontrib><creatorcontrib>Brewer, G. O. I.</creatorcontrib><creatorcontrib>Kumbhari, V.</creatorcontrib><creatorcontrib>Sharaiha, R.</creatorcontrib><creatorcontrib>Khashab, Mouen A.</creatorcontrib><title>A large multicenter cohort on the use of full-thickness resection device for difficult colonic lesions</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><addtitle>Surg Endosc</addtitle><description>Background
Introduction of the full-thickness resection device (FTRD) has allowed endoscopic resection of difficult lesions such as those with deep wall origin/infiltration or those located in difficult anatomic locations. The aim of this study is to assess the outcomes of the FTRD among its early users in the USA.
Methods
Patients who underwent endoscopic full-thickness resection (EFTR) for lower gastrointestinal tract lesions using the FTRD at 26 US tertiary care centers between 10/2017 and 12/2018 were included. Primary outcome was R0 resection rate. Secondary outcomes included rate of technical success (en bloc resection), achievement of histologic full-thickness resection (FTR), and adverse events (AE).
Results
A total of 95 patients (mean age 65.5 ± 12.6 year, 38.9% F) were included. The most common indication, for use of FTRD, was resection of difficult adenomas (non-lifting, recurrent, residual, or involving appendiceal orifice/diverticular opening) (66.3%), followed by adenocarcinomas (22.1%), and subepithelial tumors (SET) (11.6%). Lesions were located in the proximal colon (61.1%), distal colon (18.9%), or rectum (20%). Mean lesion diameter was 15.5 ± 6.4 mm and 61.1% had a prior resection attempt. The mean total procedure time was 59.7 ± 31.8 min. R0 resection was achieved in 82.7% while technical success was achieved in 84.2%. Histologically FTR was demonstrated in 88.1% of patients. There were five clinical AE (5.3%) with 2 (2.1%) requiring surgical intervention.
Conclusions
Results from this first US multicenter study suggest that EFTR with the FTRD is a technically feasible, safe, and effective technique for resecting difficult colonic lesions.</description><subject>Abdominal Surgery</subject><subject>Colon</subject><subject>Colonoscopy</subject><subject>Endoscopy</subject><subject>Gastroenterology</subject><subject>Gynecology</subject><subject>Hepatology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Polyps</subject><subject>Proctology</subject><subject>Success</subject><subject>Surgery</subject><subject>Tumors</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kc1u1TAQhS1ERS-FF2CBLLHpxnT8kzheVhUUpEpsYG0l9rg3xTcudoLE2zPlFpBYsLAsa75zZsaHsVcS3koAe9EATG8EKBBgOzDCPWE7abQSSsnhKduB0yCUdeaUPW_tDoh3snvGTjXV6SV3LF3yPNZb5Ictr3PAZcXKQ9mXuvKy8HWPfGvIS-Jpy1ms-zl8XbA1XrFhWGdiIn4nIU-l8jinNAdyIotcljnwjI2Y9oKdpDE3fPl4n7Ev7999vvogbj5df7y6vBHBGLmKoR8DTIONk8Uw6E5ZM_SQbBf7LjpaVianUhwTBIxWTipOOMkR6IxGO6PP2PnR976Wbxu21R_mFjDnccGyNa-0pcWlU5rQN_-gd2WrC03nlRmcg6GXD5Q6UqGW1iomf1_nw1h_eAn-IQV_TMFTCv5XCt6R6PWj9TYdMP6R_P52AvQRaFRabrH-7f0f258VfZLs</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Ichkhanian, Y.</creator><creator>Vosoughi, K.</creator><creator>Diehl, D. L.</creator><creator>Grimm, I. S.</creator><creator>James, T. W.</creator><creator>Templeton, A. W.</creator><creator>Hajifathalian, K.</creator><creator>Tokar, J. L.</creator><creator>Samarasena, J. B.</creator><creator>Chehade, N. El Hage</creator><creator>Lee, J.</creator><creator>Chang, K.</creator><creator>Mizrahi, M.</creator><creator>Barawi, M.</creator><creator>Irani, S.</creator><creator>Friedland, S.</creator><creator>Korc, P.</creator><creator>Aadam, A. A.</creator><creator>Al-Haddad, M. A.</creator><creator>Kowalski, T. E.</creator><creator>Novikov, A.</creator><creator>Smallfield, G.</creator><creator>Ginsberg, G. G.</creator><creator>Oza, V. M.</creator><creator>Panuu, D.</creator><creator>Fukami, N.</creator><creator>Pohl, H.</creator><creator>Lajin, Michael</creator><creator>Kumta, N. A.</creator><creator>Tang, S. J.</creator><creator>Naga, Y. M.</creator><creator>Amateau, S. K.</creator><creator>Brewer, G. O. I.</creator><creator>Kumbhari, V.</creator><creator>Sharaiha, R.</creator><creator>Khashab, Mouen A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210301</creationdate><title>A large multicenter cohort on the use of full-thickness resection device for difficult colonic lesions</title><author>Ichkhanian, Y. ; Vosoughi, K. ; Diehl, D. L. ; Grimm, I. S. ; James, T. W. ; Templeton, A. W. ; Hajifathalian, K. ; Tokar, J. L. ; Samarasena, J. B. ; Chehade, N. El Hage ; Lee, J. ; Chang, K. ; Mizrahi, M. ; Barawi, M. ; Irani, S. ; Friedland, S. ; Korc, P. ; Aadam, A. A. ; Al-Haddad, M. A. ; Kowalski, T. E. ; Novikov, A. ; Smallfield, G. ; Ginsberg, G. G. ; Oza, V. M. ; Panuu, D. ; Fukami, N. ; Pohl, H. ; Lajin, Michael ; Kumta, N. A. ; Tang, S. J. ; Naga, Y. M. ; Amateau, S. K. ; Brewer, G. O. I. ; Kumbhari, V. ; Sharaiha, R. ; Khashab, Mouen A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-86ac0b87db7ec835274860f75d65d94641f92fdaf0ced71b2dbeb1a0b1aa43943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdominal Surgery</topic><topic>Colon</topic><topic>Colonoscopy</topic><topic>Endoscopy</topic><topic>Gastroenterology</topic><topic>Gynecology</topic><topic>Hepatology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Polyps</topic><topic>Proctology</topic><topic>Success</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ichkhanian, Y.</creatorcontrib><creatorcontrib>Vosoughi, K.</creatorcontrib><creatorcontrib>Diehl, D. L.</creatorcontrib><creatorcontrib>Grimm, I. S.</creatorcontrib><creatorcontrib>James, T. W.</creatorcontrib><creatorcontrib>Templeton, A. W.</creatorcontrib><creatorcontrib>Hajifathalian, K.</creatorcontrib><creatorcontrib>Tokar, J. L.</creatorcontrib><creatorcontrib>Samarasena, J. B.</creatorcontrib><creatorcontrib>Chehade, N. El Hage</creatorcontrib><creatorcontrib>Lee, J.</creatorcontrib><creatorcontrib>Chang, K.</creatorcontrib><creatorcontrib>Mizrahi, M.</creatorcontrib><creatorcontrib>Barawi, M.</creatorcontrib><creatorcontrib>Irani, S.</creatorcontrib><creatorcontrib>Friedland, S.</creatorcontrib><creatorcontrib>Korc, P.</creatorcontrib><creatorcontrib>Aadam, A. A.</creatorcontrib><creatorcontrib>Al-Haddad, M. A.</creatorcontrib><creatorcontrib>Kowalski, T. E.</creatorcontrib><creatorcontrib>Novikov, A.</creatorcontrib><creatorcontrib>Smallfield, G.</creatorcontrib><creatorcontrib>Ginsberg, G. G.</creatorcontrib><creatorcontrib>Oza, V. M.</creatorcontrib><creatorcontrib>Panuu, D.</creatorcontrib><creatorcontrib>Fukami, N.</creatorcontrib><creatorcontrib>Pohl, H.</creatorcontrib><creatorcontrib>Lajin, Michael</creatorcontrib><creatorcontrib>Kumta, N. A.</creatorcontrib><creatorcontrib>Tang, S. J.</creatorcontrib><creatorcontrib>Naga, Y. M.</creatorcontrib><creatorcontrib>Amateau, S. K.</creatorcontrib><creatorcontrib>Brewer, G. O. I.</creatorcontrib><creatorcontrib>Kumbhari, V.</creatorcontrib><creatorcontrib>Sharaiha, R.</creatorcontrib><creatorcontrib>Khashab, Mouen A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ichkhanian, Y.</au><au>Vosoughi, K.</au><au>Diehl, D. L.</au><au>Grimm, I. S.</au><au>James, T. W.</au><au>Templeton, A. W.</au><au>Hajifathalian, K.</au><au>Tokar, J. L.</au><au>Samarasena, J. B.</au><au>Chehade, N. El Hage</au><au>Lee, J.</au><au>Chang, K.</au><au>Mizrahi, M.</au><au>Barawi, M.</au><au>Irani, S.</au><au>Friedland, S.</au><au>Korc, P.</au><au>Aadam, A. A.</au><au>Al-Haddad, M. A.</au><au>Kowalski, T. E.</au><au>Novikov, A.</au><au>Smallfield, G.</au><au>Ginsberg, G. G.</au><au>Oza, V. M.</au><au>Panuu, D.</au><au>Fukami, N.</au><au>Pohl, H.</au><au>Lajin, Michael</au><au>Kumta, N. A.</au><au>Tang, S. J.</au><au>Naga, Y. M.</au><au>Amateau, S. K.</au><au>Brewer, G. O. I.</au><au>Kumbhari, V.</au><au>Sharaiha, R.</au><au>Khashab, Mouen A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A large multicenter cohort on the use of full-thickness resection device for difficult colonic lesions</atitle><jtitle>Surgical endoscopy</jtitle><stitle>Surg Endosc</stitle><addtitle>Surg Endosc</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>35</volume><issue>3</issue><spage>1296</spage><epage>1306</epage><pages>1296-1306</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><abstract>Background
Introduction of the full-thickness resection device (FTRD) has allowed endoscopic resection of difficult lesions such as those with deep wall origin/infiltration or those located in difficult anatomic locations. The aim of this study is to assess the outcomes of the FTRD among its early users in the USA.
Methods
Patients who underwent endoscopic full-thickness resection (EFTR) for lower gastrointestinal tract lesions using the FTRD at 26 US tertiary care centers between 10/2017 and 12/2018 were included. Primary outcome was R0 resection rate. Secondary outcomes included rate of technical success (en bloc resection), achievement of histologic full-thickness resection (FTR), and adverse events (AE).
Results
A total of 95 patients (mean age 65.5 ± 12.6 year, 38.9% F) were included. The most common indication, for use of FTRD, was resection of difficult adenomas (non-lifting, recurrent, residual, or involving appendiceal orifice/diverticular opening) (66.3%), followed by adenocarcinomas (22.1%), and subepithelial tumors (SET) (11.6%). Lesions were located in the proximal colon (61.1%), distal colon (18.9%), or rectum (20%). Mean lesion diameter was 15.5 ± 6.4 mm and 61.1% had a prior resection attempt. The mean total procedure time was 59.7 ± 31.8 min. R0 resection was achieved in 82.7% while technical success was achieved in 84.2%. Histologically FTR was demonstrated in 88.1% of patients. There were five clinical AE (5.3%) with 2 (2.1%) requiring surgical intervention.
Conclusions
Results from this first US multicenter study suggest that EFTR with the FTRD is a technically feasible, safe, and effective technique for resecting difficult colonic lesions.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32180001</pmid><doi>10.1007/s00464-020-07504-9</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0930-2794 |
| ispartof | Surgical endoscopy, 2021-03, Vol.35 (3), p.1296-1306 |
| issn | 0930-2794 1432-2218 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2378001923 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Abdominal Surgery Colon Colonoscopy Endoscopy Gastroenterology Gynecology Hepatology Medicine Medicine & Public Health Polyps Proctology Success Surgery Tumors |
| title | A large multicenter cohort on the use of full-thickness resection device for difficult colonic lesions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T10%3A23%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20large%20multicenter%20cohort%20on%20the%20use%20of%20full-thickness%20resection%20device%20for%20difficult%20colonic%20lesions&rft.jtitle=Surgical%20endoscopy&rft.au=Ichkhanian,%20Y.&rft.date=2021-03-01&rft.volume=35&rft.issue=3&rft.spage=1296&rft.epage=1306&rft.pages=1296-1306&rft.issn=0930-2794&rft.eissn=1432-2218&rft_id=info:doi/10.1007/s00464-020-07504-9&rft_dat=%3Cproquest_cross%3E2489908613%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2489908613&rft_id=info:pmid/32180001&rfr_iscdi=true |