Fitness is improved by adjustments in muscle intracellular signaling in rats with renovascular hypertension 2K1C undergoing voluntary physical exercise

To evaluate physical fitness and cardiovascular effects in rats with renovascular hypertension, two kidneys, one clip (2K1C) submitted to voluntary exercise (ExV). 24 h after surgery (SHAM and 2K1C) rats were submitted to ExV for one week (adaptation). ExV adherent rats were separated into exercise...

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Veröffentlicht in:	Life sciences (1973) 2020-06, Vol.250, p.117549-10, Article 117549
Hauptverfasser:	Lima, Taynara Carolina, Barbosa, Maria Andrea, Costa, Daniela Caldeira, Becker, Lenice Kappes, Cardoso, Leonardo Máximo, Alzamora, Andréia Carvalho
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Animals Baroreceptors Baroreflex - drug effects Blood levels Blood pressure Blood Pressure - drug effects Bradycardia Disease Models, Animal Exercise Exercise voluntary running Exhaustion Fitness Gastrocnemius muscle Gene expression Heart Rate - drug effects Hexamethonium Hypertension Hypertension, Renovascular - metabolism Intracellular Intracellular signalling Kidney - drug effects Kidneys Lactate Lactic acid Losartan - pharmacology Male Metabolism Monocyte chemoattractant protein 1 Muscle, Skeletal - metabolism Muscles Oxidation-Reduction Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism PGC1α Physical Conditioning, Animal Physical exercise Physical fitness Rats Rats, Inbred F344 Reflexes Renovascular hypertension Signal Transduction Signaling Sirtuin 1 - metabolism Surgery Sympathetic Nervous System - drug effects Uncoupling Protein 3 - metabolism
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