WRKY13 Enhances Cadmium Tolerance by Promoting D-CYSTEINE DESULFHYDRASE and Hydrogen Sulfide Production
Hydrogen sulfide (H S), a plant gasotransmitter, functions in the plant response to cadmium (Cd) stress, implying a role for cysteine desulfhydrase in producing H S in this process. Whether ( ) acts in the plant Cd response remains to be identified, and if it does, how is regulated in this process i...
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| Veröffentlicht in: | Plant physiology (Bethesda) 2020-05, Vol.183 (1), p.345-357 |
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| creator | Zhang, Qing Cai, Wei Ji, Tong-Tong Ye, Ling Lu, Ying-Tang Yuan, Ting-Ting |
| description | Hydrogen sulfide (H
S), a plant gasotransmitter, functions in the plant response to cadmium (Cd) stress, implying a role for cysteine desulfhydrase in producing H
S in this process. Whether
(
) acts in the plant Cd response remains to be identified, and if it does, how
is regulated in this process is also unknown. Here, we report that
-mediated H
S production enhances plant Cd tolerance in Arabidopsis (
). When subjected to Cd stress, a
mutant accumulated more Cd and reactive oxygen species and showed increased Cd sensitivity, whereas transgenic lines overexpressing
had decreased Cd and reactive oxygen species levels and were more tolerant to Cd stress compared with wild-type plants. Furthermore, the expression of
was stimulated by Cd stress, and this up-regulation was mediated by a Cd-induced transcription factor, WRKY13, which bound to the
promoter. Consistently, the higher Cd sensitivity of the
mutant was rescued by the overexpression of
Together, our results demonstrate that Cd-induced WRKY13 activates
expression to increase the production of H
S, leading to higher Cd tolerance in plants. |
| doi_str_mv | 10.1104/pp.19.01504 |
| format | Article |
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S), a plant gasotransmitter, functions in the plant response to cadmium (Cd) stress, implying a role for cysteine desulfhydrase in producing H
S in this process. Whether
(
) acts in the plant Cd response remains to be identified, and if it does, how
is regulated in this process is also unknown. Here, we report that
-mediated H
S production enhances plant Cd tolerance in Arabidopsis (
). When subjected to Cd stress, a
mutant accumulated more Cd and reactive oxygen species and showed increased Cd sensitivity, whereas transgenic lines overexpressing
had decreased Cd and reactive oxygen species levels and were more tolerant to Cd stress compared with wild-type plants. Furthermore, the expression of
was stimulated by Cd stress, and this up-regulation was mediated by a Cd-induced transcription factor, WRKY13, which bound to the
promoter. Consistently, the higher Cd sensitivity of the
mutant was rescued by the overexpression of
Together, our results demonstrate that Cd-induced WRKY13 activates
expression to increase the production of H
S, leading to higher Cd tolerance in plants.</description><identifier>ISSN: 0032-0889</identifier><identifier>ISSN: 1532-2548</identifier><identifier>EISSN: 1532-2548</identifier><identifier>DOI: 10.1104/pp.19.01504</identifier><identifier>PMID: 32179630</identifier><language>eng</language><publisher>United States: American Society of Plant Biologists</publisher><subject>Arabidopsis - drug effects ; Arabidopsis - genetics ; Arabidopsis - metabolism ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Cadmium - pharmacology ; Cystathionine gamma-Lyase - genetics ; Cystathionine gamma-Lyase - metabolism ; Gene Expression Regulation, Plant ; Hydrogen Sulfide - metabolism ; Plants, Genetically Modified - drug effects ; Plants, Genetically Modified - genetics ; Plants, Genetically Modified - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Plant physiology (Bethesda), 2020-05, Vol.183 (1), p.345-357</ispartof><rights>2020 American Society of Plant Biologists. All Rights Reserved.</rights><rights>2020 American Society of Plant Biologists. All Rights Reserved. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-9e9b06bc308e84b9d8cbe1afc0c2e8c146bedbf78d1128b6ee35b2e0ac567f693</citedby><orcidid>0000-0002-8577-3584 ; 0000-0003-3540-6935 ; 0000-0002-7921-2991</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32179630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>Cai, Wei</creatorcontrib><creatorcontrib>Ji, Tong-Tong</creatorcontrib><creatorcontrib>Ye, Ling</creatorcontrib><creatorcontrib>Lu, Ying-Tang</creatorcontrib><creatorcontrib>Yuan, Ting-Ting</creatorcontrib><title>WRKY13 Enhances Cadmium Tolerance by Promoting D-CYSTEINE DESULFHYDRASE and Hydrogen Sulfide Production</title><title>Plant physiology (Bethesda)</title><addtitle>Plant Physiol</addtitle><description>Hydrogen sulfide (H
S), a plant gasotransmitter, functions in the plant response to cadmium (Cd) stress, implying a role for cysteine desulfhydrase in producing H
S in this process. Whether
(
) acts in the plant Cd response remains to be identified, and if it does, how
is regulated in this process is also unknown. Here, we report that
-mediated H
S production enhances plant Cd tolerance in Arabidopsis (
). When subjected to Cd stress, a
mutant accumulated more Cd and reactive oxygen species and showed increased Cd sensitivity, whereas transgenic lines overexpressing
had decreased Cd and reactive oxygen species levels and were more tolerant to Cd stress compared with wild-type plants. Furthermore, the expression of
was stimulated by Cd stress, and this up-regulation was mediated by a Cd-induced transcription factor, WRKY13, which bound to the
promoter. Consistently, the higher Cd sensitivity of the
mutant was rescued by the overexpression of
Together, our results demonstrate that Cd-induced WRKY13 activates
expression to increase the production of H
S, leading to higher Cd tolerance in plants.</description><subject>Arabidopsis - drug effects</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Cadmium - pharmacology</subject><subject>Cystathionine gamma-Lyase - genetics</subject><subject>Cystathionine gamma-Lyase - metabolism</subject><subject>Gene Expression Regulation, Plant</subject><subject>Hydrogen Sulfide - metabolism</subject><subject>Plants, Genetically Modified - drug effects</subject><subject>Plants, Genetically Modified - genetics</subject><subject>Plants, Genetically Modified - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0032-0889</issn><issn>1532-2548</issn><issn>1532-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctr20AQxpfS0rhpT72XPRaK3B2tHqtLIdhKHGLaEjsUn5Z9jBwVSavsSgX_95XzIjnNMPObb4b5CPkMbA7Aku99P4diziBlyRsyg5THUZwm4i2ZMTblTIjihHwI4S9jDDgk78kJjyEvMs5mZP_n-moHnJbdreoMBrpQtq3Hlm5dg_5YovpAf3vXuqHu9nQZLXabbXn5s6TLcnOzPl_tltdnm5KqztLVwXq3x45uxqaqLR7n7GiG2nUfybtKNQE_PcZTcnNebheraP3r4nJxto4MFzBEBRaaZdpwJlAkurDCaARVGWZiFAaSTKPVVS4sQCx0hshTHSNTJs3yKiv4KfnxoNuPukVrsBu8amTv61b5g3Sqlq87XX0r9-6fzGNgGReTwNdHAe_uRgyDbOtgsGlUh24MMua5mB7JcpjQbw-o8S4Ej9XzGmDyaI3sewmFvLdmor-8vOyZffKC_weis4ms</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Zhang, Qing</creator><creator>Cai, Wei</creator><creator>Ji, Tong-Tong</creator><creator>Ye, Ling</creator><creator>Lu, Ying-Tang</creator><creator>Yuan, Ting-Ting</creator><general>American Society of Plant Biologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8577-3584</orcidid><orcidid>https://orcid.org/0000-0003-3540-6935</orcidid><orcidid>https://orcid.org/0000-0002-7921-2991</orcidid></search><sort><creationdate>20200501</creationdate><title>WRKY13 Enhances Cadmium Tolerance by Promoting D-CYSTEINE DESULFHYDRASE and Hydrogen Sulfide Production</title><author>Zhang, Qing ; Cai, Wei ; Ji, Tong-Tong ; Ye, Ling ; Lu, Ying-Tang ; Yuan, Ting-Ting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-9e9b06bc308e84b9d8cbe1afc0c2e8c146bedbf78d1128b6ee35b2e0ac567f693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Arabidopsis - drug effects</topic><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Cadmium - pharmacology</topic><topic>Cystathionine gamma-Lyase - genetics</topic><topic>Cystathionine gamma-Lyase - metabolism</topic><topic>Gene Expression Regulation, Plant</topic><topic>Hydrogen Sulfide - metabolism</topic><topic>Plants, Genetically Modified - drug effects</topic><topic>Plants, Genetically Modified - genetics</topic><topic>Plants, Genetically Modified - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>Cai, Wei</creatorcontrib><creatorcontrib>Ji, Tong-Tong</creatorcontrib><creatorcontrib>Ye, Ling</creatorcontrib><creatorcontrib>Lu, Ying-Tang</creatorcontrib><creatorcontrib>Yuan, Ting-Ting</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Plant physiology (Bethesda)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Qing</au><au>Cai, Wei</au><au>Ji, Tong-Tong</au><au>Ye, Ling</au><au>Lu, Ying-Tang</au><au>Yuan, Ting-Ting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>WRKY13 Enhances Cadmium Tolerance by Promoting D-CYSTEINE DESULFHYDRASE and Hydrogen Sulfide Production</atitle><jtitle>Plant physiology (Bethesda)</jtitle><addtitle>Plant Physiol</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>183</volume><issue>1</issue><spage>345</spage><epage>357</epage><pages>345-357</pages><issn>0032-0889</issn><issn>1532-2548</issn><eissn>1532-2548</eissn><abstract>Hydrogen sulfide (H
S), a plant gasotransmitter, functions in the plant response to cadmium (Cd) stress, implying a role for cysteine desulfhydrase in producing H
S in this process. Whether
(
) acts in the plant Cd response remains to be identified, and if it does, how
is regulated in this process is also unknown. Here, we report that
-mediated H
S production enhances plant Cd tolerance in Arabidopsis (
). When subjected to Cd stress, a
mutant accumulated more Cd and reactive oxygen species and showed increased Cd sensitivity, whereas transgenic lines overexpressing
had decreased Cd and reactive oxygen species levels and were more tolerant to Cd stress compared with wild-type plants. Furthermore, the expression of
was stimulated by Cd stress, and this up-regulation was mediated by a Cd-induced transcription factor, WRKY13, which bound to the
promoter. Consistently, the higher Cd sensitivity of the
mutant was rescued by the overexpression of
Together, our results demonstrate that Cd-induced WRKY13 activates
expression to increase the production of H
S, leading to higher Cd tolerance in plants.</abstract><cop>United States</cop><pub>American Society of Plant Biologists</pub><pmid>32179630</pmid><doi>10.1104/pp.19.01504</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-8577-3584</orcidid><orcidid>https://orcid.org/0000-0003-3540-6935</orcidid><orcidid>https://orcid.org/0000-0002-7921-2991</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Arabidopsis - drug effects Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Cadmium - pharmacology Cystathionine gamma-Lyase - genetics Cystathionine gamma-Lyase - metabolism Gene Expression Regulation, Plant Hydrogen Sulfide - metabolism Plants, Genetically Modified - drug effects Plants, Genetically Modified - genetics Plants, Genetically Modified - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| title | WRKY13 Enhances Cadmium Tolerance by Promoting D-CYSTEINE DESULFHYDRASE and Hydrogen Sulfide Production |
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