Phase angle could be a marker of microvascular damage in systemic sclerosis
•Vascular endothelial growth factor is significantly higher in systemic sclerosis than in healthy controls.•Phase angle is significantly lower in systemic sclerosis than in healthy controls.•A significant positive correlation is found between vascular endothelial growth factor and phase angle.•Phase...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2020-05, Vol.73, p.110730-110730, Article 110730 |
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| creator | Gigante, Antonietta Gasperini, Maria Ludovica Rosato, Edoardo Navarini, Luca Margiotta, Domenico Afeltra, Antonella Muscaritoli, Maurizio |
| description | •Vascular endothelial growth factor is significantly higher in systemic sclerosis than in healthy controls.•Phase angle is significantly lower in systemic sclerosis than in healthy controls.•A significant positive correlation is found between vascular endothelial growth factor and phase angle.•Phase angle decreases with progression of digital microvascular damage.
Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction with fibrosis of skin and internal organs. Integrity of the endothelial cell is important to its physiologic function such as production of angiogenetic factors. The aim of this study was to assess whether phase angle (PhA) is altered in patients with SSc and whether its values correlate with vascular endothelial growth factor (VEGF) and digital microvascular damage.
Patients with SSc and matched healthy controls underwent VEGF determination and bioimpedentiometry (BIA) for PhA assessment. Clinical assessment, disease activity index (DAI), disease severity scale, and nailfold videocapillaroscopy (NCV) were performed in patients with SSc.
Fifty-five patients (46 women) with a mean age of 53.2 ± 13.7 y were studied. The mean value of VEGF was significantly higher in patients with SSc than in the healthy controls (240.3 ± 149.5 versus 139 ± 87.5; P = 0.035). The mean value of PhA was significantly lower in the patient grouop than in the healthy controls (4.51 ± 0.87 versus 5.22 ± 0.55; P < 0.0001). A significant positive correlation was found between VEGF and PhA (P = 0.009, beta coefficient = 1.48) in SSc patients. A negative correlation between VEGF and DAI (P = 0.048, β coefficient = 0.48) was found. PhA median value was significantly (P = 0.006) lower in patients with late pattern SSc (4.2 [2.5–5.3]). PhA median value was significantly (P < 0,0001) lower in patients with digital ulcers (DUs; 4.2 [2.5–5.3]) than in those without DUs (3.80 [2.50–5] versus 4.75 [2.80–7.3]). These data were confirmed in both female and male patients.
The evaluation of VEGF with PhA, NVC, and DUs could be useful to estimate cellular and microvascular damage in patients with SSc. |
| doi_str_mv | 10.1016/j.nut.2020.110730 |
| format | Article |
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Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction with fibrosis of skin and internal organs. Integrity of the endothelial cell is important to its physiologic function such as production of angiogenetic factors. The aim of this study was to assess whether phase angle (PhA) is altered in patients with SSc and whether its values correlate with vascular endothelial growth factor (VEGF) and digital microvascular damage.
Patients with SSc and matched healthy controls underwent VEGF determination and bioimpedentiometry (BIA) for PhA assessment. Clinical assessment, disease activity index (DAI), disease severity scale, and nailfold videocapillaroscopy (NCV) were performed in patients with SSc.
Fifty-five patients (46 women) with a mean age of 53.2 ± 13.7 y were studied. The mean value of VEGF was significantly higher in patients with SSc than in the healthy controls (240.3 ± 149.5 versus 139 ± 87.5; P = 0.035). The mean value of PhA was significantly lower in the patient grouop than in the healthy controls (4.51 ± 0.87 versus 5.22 ± 0.55; P < 0.0001). A significant positive correlation was found between VEGF and PhA (P = 0.009, beta coefficient = 1.48) in SSc patients. A negative correlation between VEGF and DAI (P = 0.048, β coefficient = 0.48) was found. PhA median value was significantly (P = 0.006) lower in patients with late pattern SSc (4.2 [2.5–5.3]). PhA median value was significantly (P < 0,0001) lower in patients with digital ulcers (DUs; 4.2 [2.5–5.3]) than in those without DUs (3.80 [2.50–5] versus 4.75 [2.80–7.3]). These data were confirmed in both female and male patients.
The evaluation of VEGF with PhA, NVC, and DUs could be useful to estimate cellular and microvascular damage in patients with SSc.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2020.110730</identifier><identifier>PMID: 32179402</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age ; Angiogenesis ; Autoimmune diseases ; Body composition ; Body mass index ; Capillaroscopy ; Clinical medicine ; Correlation ; Damage ; Diabetes ; Disease ; Endothelial cells ; Females ; Fibrosis ; Growth factors ; Hypertension ; Membranes ; Microvasculature ; Organs ; Phase angle ; Phase shift ; Regression analysis ; Scleroderma ; Skin ; Systemic sclerosis ; Ulcers ; Vascular endothelial growth factor ; Vasculopathy ; VEGF ; Womens health</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2020-05, Vol.73, p.110730-110730, Article 110730</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><rights>2020. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-ffbcf3ae542c81e4848e8b439f08dea308a8b0f9accd259a0e56ef253ec627ae3</citedby><cites>FETCH-LOGICAL-c381t-ffbcf3ae542c81e4848e8b439f08dea308a8b0f9accd259a0e56ef253ec627ae3</cites><orcidid>0000-0002-6432-0236 ; 0000-0002-2015-765X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2425691372?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32179402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gigante, Antonietta</creatorcontrib><creatorcontrib>Gasperini, Maria Ludovica</creatorcontrib><creatorcontrib>Rosato, Edoardo</creatorcontrib><creatorcontrib>Navarini, Luca</creatorcontrib><creatorcontrib>Margiotta, Domenico</creatorcontrib><creatorcontrib>Afeltra, Antonella</creatorcontrib><creatorcontrib>Muscaritoli, Maurizio</creatorcontrib><title>Phase angle could be a marker of microvascular damage in systemic sclerosis</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>•Vascular endothelial growth factor is significantly higher in systemic sclerosis than in healthy controls.•Phase angle is significantly lower in systemic sclerosis than in healthy controls.•A significant positive correlation is found between vascular endothelial growth factor and phase angle.•Phase angle decreases with progression of digital microvascular damage.
Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction with fibrosis of skin and internal organs. Integrity of the endothelial cell is important to its physiologic function such as production of angiogenetic factors. The aim of this study was to assess whether phase angle (PhA) is altered in patients with SSc and whether its values correlate with vascular endothelial growth factor (VEGF) and digital microvascular damage.
Patients with SSc and matched healthy controls underwent VEGF determination and bioimpedentiometry (BIA) for PhA assessment. Clinical assessment, disease activity index (DAI), disease severity scale, and nailfold videocapillaroscopy (NCV) were performed in patients with SSc.
Fifty-five patients (46 women) with a mean age of 53.2 ± 13.7 y were studied. The mean value of VEGF was significantly higher in patients with SSc than in the healthy controls (240.3 ± 149.5 versus 139 ± 87.5; P = 0.035). The mean value of PhA was significantly lower in the patient grouop than in the healthy controls (4.51 ± 0.87 versus 5.22 ± 0.55; P < 0.0001). A significant positive correlation was found between VEGF and PhA (P = 0.009, beta coefficient = 1.48) in SSc patients. A negative correlation between VEGF and DAI (P = 0.048, β coefficient = 0.48) was found. PhA median value was significantly (P = 0.006) lower in patients with late pattern SSc (4.2 [2.5–5.3]). PhA median value was significantly (P < 0,0001) lower in patients with digital ulcers (DUs; 4.2 [2.5–5.3]) than in those without DUs (3.80 [2.50–5] versus 4.75 [2.80–7.3]). These data were confirmed in both female and male patients.
The evaluation of VEGF with PhA, NVC, and DUs could be useful to estimate cellular and microvascular damage in patients with SSc.</description><subject>Age</subject><subject>Angiogenesis</subject><subject>Autoimmune diseases</subject><subject>Body composition</subject><subject>Body mass index</subject><subject>Capillaroscopy</subject><subject>Clinical medicine</subject><subject>Correlation</subject><subject>Damage</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Endothelial cells</subject><subject>Females</subject><subject>Fibrosis</subject><subject>Growth factors</subject><subject>Hypertension</subject><subject>Membranes</subject><subject>Microvasculature</subject><subject>Organs</subject><subject>Phase angle</subject><subject>Phase shift</subject><subject>Regression analysis</subject><subject>Scleroderma</subject><subject>Skin</subject><subject>Systemic sclerosis</subject><subject>Ulcers</subject><subject>Vascular endothelial growth 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angle could be a marker of microvascular damage in systemic sclerosis</title><author>Gigante, Antonietta ; Gasperini, Maria Ludovica ; Rosato, Edoardo ; Navarini, Luca ; Margiotta, Domenico ; Afeltra, Antonella ; Muscaritoli, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-ffbcf3ae542c81e4848e8b439f08dea308a8b0f9accd259a0e56ef253ec627ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Angiogenesis</topic><topic>Autoimmune diseases</topic><topic>Body composition</topic><topic>Body mass index</topic><topic>Capillaroscopy</topic><topic>Clinical medicine</topic><topic>Correlation</topic><topic>Damage</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Endothelial cells</topic><topic>Females</topic><topic>Fibrosis</topic><topic>Growth 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Edoardo</au><au>Navarini, Luca</au><au>Margiotta, Domenico</au><au>Afeltra, Antonella</au><au>Muscaritoli, Maurizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phase angle could be a marker of microvascular damage in systemic sclerosis</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2020-05</date><risdate>2020</risdate><volume>73</volume><spage>110730</spage><epage>110730</epage><pages>110730-110730</pages><artnum>110730</artnum><issn>0899-9007</issn><eissn>1873-1244</eissn><abstract>•Vascular endothelial growth factor is significantly higher in systemic sclerosis than in healthy controls.•Phase angle is significantly lower in systemic sclerosis than in healthy controls.•A significant positive correlation is found between vascular endothelial growth factor and phase angle.•Phase angle decreases with progression of digital microvascular damage.
Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction with fibrosis of skin and internal organs. Integrity of the endothelial cell is important to its physiologic function such as production of angiogenetic factors. The aim of this study was to assess whether phase angle (PhA) is altered in patients with SSc and whether its values correlate with vascular endothelial growth factor (VEGF) and digital microvascular damage.
Patients with SSc and matched healthy controls underwent VEGF determination and bioimpedentiometry (BIA) for PhA assessment. Clinical assessment, disease activity index (DAI), disease severity scale, and nailfold videocapillaroscopy (NCV) were performed in patients with SSc.
Fifty-five patients (46 women) with a mean age of 53.2 ± 13.7 y were studied. The mean value of VEGF was significantly higher in patients with SSc than in the healthy controls (240.3 ± 149.5 versus 139 ± 87.5; P = 0.035). The mean value of PhA was significantly lower in the patient grouop than in the healthy controls (4.51 ± 0.87 versus 5.22 ± 0.55; P < 0.0001). A significant positive correlation was found between VEGF and PhA (P = 0.009, beta coefficient = 1.48) in SSc patients. A negative correlation between VEGF and DAI (P = 0.048, β coefficient = 0.48) was found. PhA median value was significantly (P = 0.006) lower in patients with late pattern SSc (4.2 [2.5–5.3]). PhA median value was significantly (P < 0,0001) lower in patients with digital ulcers (DUs; 4.2 [2.5–5.3]) than in those without DUs (3.80 [2.50–5] versus 4.75 [2.80–7.3]). These data were confirmed in both female and male patients.
The evaluation of VEGF with PhA, NVC, and DUs could be useful to estimate cellular and microvascular damage in patients with SSc.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32179402</pmid><doi>10.1016/j.nut.2020.110730</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6432-0236</orcidid><orcidid>https://orcid.org/0000-0002-2015-765X</orcidid></addata></record> |
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| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2020-05, Vol.73, p.110730-110730, Article 110730 |
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| subjects | Age Angiogenesis Autoimmune diseases Body composition Body mass index Capillaroscopy Clinical medicine Correlation Damage Diabetes Disease Endothelial cells Females Fibrosis Growth factors Hypertension Membranes Microvasculature Organs Phase angle Phase shift Regression analysis Scleroderma Skin Systemic sclerosis Ulcers Vascular endothelial growth factor Vasculopathy VEGF Womens health |
| title | Phase angle could be a marker of microvascular damage in systemic sclerosis |
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