Long-term Evolution of Hepatocellular Adenomas at MRI Follow-up
Background Hepatocellular adenomas (HCAs) are rare benign liver tumors. Guidelines recommend continued surveillance of patients diagnosed with HCAs, but these guidelines are mainly based on small studies or expert opinion. Purpose To analyze the long-term evolution of HCAs, including solitary and mu...
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| Veröffentlicht in: | Radiology 2020-05, Vol.295 (2), p.361-372 |
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| creator | Vernuccio, Federica Ronot, Maxime Dioguardi Burgio, Marco Cauchy, François Choudhury, Kingshuk R Dokmak, Safi Soubrane, Olivier Valla, Dominique Zucman-Rossi, Jessica Paradis, Valérie Vilgrain, Valérie |
| description | Background Hepatocellular adenomas (HCAs) are rare benign liver tumors. Guidelines recommend continued surveillance of patients diagnosed with HCAs, but these guidelines are mainly based on small studies or expert opinion. Purpose To analyze the long-term evolution of HCAs, including solitary and multiple lesions, and to identify predictive features of progression with MRI. Materials and Methods In a retrospective study, patients diagnosed with pathologically proven solitary or multiple HCAs between January 2004 and December 2015 were included; β-catenin-mutated HCAs and HCAs with foci of malignancy were considered to be at risk for progression. MRI examinations were analyzed, and tumor evolution was evaluated by using Response Evaluation Criteria in Solid Tumors, version 1.1. Student
Mann-Whitney, χ
, Fisher exact, and McNemar tests were used, as appropriate. Results In total, 118 patients (mean age, 40 years ± 10 [standard deviation]; 108 women) were evaluated, including 41 with a solitary HCA (mean age, 40 years ± 14; 36 women) and 77 with multiple HCAs (mean age, 40 years ± 10; 72 women). At a median follow-up of 5 years, 37 of 41 (90%) patients with a solitary HCA and 55 of 77 (71%) patients with multiple HCAs showed stable or regressive disease. After resection of solitary HCAs, new lesions appeared in only two of 29 (7%) patients, both of whom had HCAs at risk of progression. In patients with multiple HCAs, hepatocyte nuclear factor 1α-inactivated HCAs showed a higher rate of progression compared with inflammatory HCAs (11 of 26 [42%] vs seven of 37 [19%],
= .04) despite lower use (28 of 32 patients [88%] vs 45 of 45 patients [100%];
= .03) and shorter duration (mean, 12.0 years ± 7.5 vs 19.2 years ± 9.2;
= .001) of oral contraceptive intake. Conclusion Long-term MRI follow-up showed that 78% of hepatocellular adenomas had long-term stability or regression. After resection of solitary hepatocellular adenomas, new lesions occurred only in hepatocellular adenomas at risk of progression. Patients with multiple hepatocellular adenomas were more likely to show progressive disease, with hepatic nuclear factor 1α-inactivated hepatocellular adenomas being the most common subtype showing progression. © RSNA, 2020 |
| doi_str_mv | 10.1148/radiol.2020191790 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2377991159</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2377991159</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-32a1d5ed8fb5c20ad9ca5b1816a9f61f146b8ac9eb3dcf63332931c1524805363</originalsourceid><addsrcrecordid>eNpFkEFLwzAcxYMobk4_gBfJ0Utn_knTJicZY3ODiSB6DmmaSiVtatIqfns7NvX0Lu893vshdA1kDpCKu6DL2rs5JZSAhFySEzQFTvMEGPBTNCWEsUSkICfoIsZ3QiDlIj9HE0ZBQE7FFN3vfPuW9DY0ePXp3dDXvsW-whvb6d4b69zgdMCL0ra-0RHrHj8-b_HaO-e_kqG7RGeVdtFeHXWGXterl-Um2T09bJeLXWJSIH3CqIaS21JUBTeU6FIazYtxRKZllUEFaVYIbaQtWGmqjDFGJQMznkkF4SxjM3R76O2C_xhs7FVTx_083Vo_REVZnksJwOVohYPVBB9jsJXqQt3o8K2AqD03deCm_rmNmZtj_VA0tvxL_IJiP9RsaOw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2377991159</pqid></control><display><type>article</type><title>Long-term Evolution of Hepatocellular Adenomas at MRI Follow-up</title><source>MEDLINE</source><source>Radiological Society of North America</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Vernuccio, Federica ; Ronot, Maxime ; Dioguardi Burgio, Marco ; Cauchy, François ; Choudhury, Kingshuk R ; Dokmak, Safi ; Soubrane, Olivier ; Valla, Dominique ; Zucman-Rossi, Jessica ; Paradis, Valérie ; Vilgrain, Valérie</creator><creatorcontrib>Vernuccio, Federica ; Ronot, Maxime ; Dioguardi Burgio, Marco ; Cauchy, François ; Choudhury, Kingshuk R ; Dokmak, Safi ; Soubrane, Olivier ; Valla, Dominique ; Zucman-Rossi, Jessica ; Paradis, Valérie ; Vilgrain, Valérie</creatorcontrib><description>Background Hepatocellular adenomas (HCAs) are rare benign liver tumors. Guidelines recommend continued surveillance of patients diagnosed with HCAs, but these guidelines are mainly based on small studies or expert opinion. Purpose To analyze the long-term evolution of HCAs, including solitary and multiple lesions, and to identify predictive features of progression with MRI. Materials and Methods In a retrospective study, patients diagnosed with pathologically proven solitary or multiple HCAs between January 2004 and December 2015 were included; β-catenin-mutated HCAs and HCAs with foci of malignancy were considered to be at risk for progression. MRI examinations were analyzed, and tumor evolution was evaluated by using Response Evaluation Criteria in Solid Tumors, version 1.1. Student
Mann-Whitney, χ
, Fisher exact, and McNemar tests were used, as appropriate. Results In total, 118 patients (mean age, 40 years ± 10 [standard deviation]; 108 women) were evaluated, including 41 with a solitary HCA (mean age, 40 years ± 14; 36 women) and 77 with multiple HCAs (mean age, 40 years ± 10; 72 women). At a median follow-up of 5 years, 37 of 41 (90%) patients with a solitary HCA and 55 of 77 (71%) patients with multiple HCAs showed stable or regressive disease. After resection of solitary HCAs, new lesions appeared in only two of 29 (7%) patients, both of whom had HCAs at risk of progression. In patients with multiple HCAs, hepatocyte nuclear factor 1α-inactivated HCAs showed a higher rate of progression compared with inflammatory HCAs (11 of 26 [42%] vs seven of 37 [19%],
= .04) despite lower use (28 of 32 patients [88%] vs 45 of 45 patients [100%];
= .03) and shorter duration (mean, 12.0 years ± 7.5 vs 19.2 years ± 9.2;
= .001) of oral contraceptive intake. Conclusion Long-term MRI follow-up showed that 78% of hepatocellular adenomas had long-term stability or regression. After resection of solitary hepatocellular adenomas, new lesions occurred only in hepatocellular adenomas at risk of progression. Patients with multiple hepatocellular adenomas were more likely to show progressive disease, with hepatic nuclear factor 1α-inactivated hepatocellular adenomas being the most common subtype showing progression. © RSNA, 2020</description><identifier>ISSN: 0033-8419</identifier><identifier>EISSN: 1527-1315</identifier><identifier>DOI: 10.1148/radiol.2020191790</identifier><identifier>PMID: 32181728</identifier><language>eng</language><publisher>United States</publisher><subject>Adenoma, Liver Cell - diagnostic imaging ; Adenoma, Liver Cell - pathology ; Adult ; Disease Progression ; Female ; Humans ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - pathology ; Magnetic Resonance Imaging - methods ; Male ; Response Evaluation Criteria in Solid Tumors ; Retrospective Studies</subject><ispartof>Radiology, 2020-05, Vol.295 (2), p.361-372</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-32a1d5ed8fb5c20ad9ca5b1816a9f61f146b8ac9eb3dcf63332931c1524805363</citedby><cites>FETCH-LOGICAL-c410t-32a1d5ed8fb5c20ad9ca5b1816a9f61f146b8ac9eb3dcf63332931c1524805363</cites><orcidid>0000-0001-7464-3939 ; 0000-0002-3243-6699 ; 0000-0002-4460-7643 ; 0000-0002-3568-7725 ; 0000-0002-0306-2915 ; 0000-0002-4997-3730 ; 0000-0003-0350-1794 ; 0000-0002-3335-4388</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4002,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32181728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vernuccio, Federica</creatorcontrib><creatorcontrib>Ronot, Maxime</creatorcontrib><creatorcontrib>Dioguardi Burgio, Marco</creatorcontrib><creatorcontrib>Cauchy, François</creatorcontrib><creatorcontrib>Choudhury, Kingshuk R</creatorcontrib><creatorcontrib>Dokmak, Safi</creatorcontrib><creatorcontrib>Soubrane, Olivier</creatorcontrib><creatorcontrib>Valla, Dominique</creatorcontrib><creatorcontrib>Zucman-Rossi, Jessica</creatorcontrib><creatorcontrib>Paradis, Valérie</creatorcontrib><creatorcontrib>Vilgrain, Valérie</creatorcontrib><title>Long-term Evolution of Hepatocellular Adenomas at MRI Follow-up</title><title>Radiology</title><addtitle>Radiology</addtitle><description>Background Hepatocellular adenomas (HCAs) are rare benign liver tumors. Guidelines recommend continued surveillance of patients diagnosed with HCAs, but these guidelines are mainly based on small studies or expert opinion. Purpose To analyze the long-term evolution of HCAs, including solitary and multiple lesions, and to identify predictive features of progression with MRI. Materials and Methods In a retrospective study, patients diagnosed with pathologically proven solitary or multiple HCAs between January 2004 and December 2015 were included; β-catenin-mutated HCAs and HCAs with foci of malignancy were considered to be at risk for progression. MRI examinations were analyzed, and tumor evolution was evaluated by using Response Evaluation Criteria in Solid Tumors, version 1.1. Student
Mann-Whitney, χ
, Fisher exact, and McNemar tests were used, as appropriate. Results In total, 118 patients (mean age, 40 years ± 10 [standard deviation]; 108 women) were evaluated, including 41 with a solitary HCA (mean age, 40 years ± 14; 36 women) and 77 with multiple HCAs (mean age, 40 years ± 10; 72 women). At a median follow-up of 5 years, 37 of 41 (90%) patients with a solitary HCA and 55 of 77 (71%) patients with multiple HCAs showed stable or regressive disease. After resection of solitary HCAs, new lesions appeared in only two of 29 (7%) patients, both of whom had HCAs at risk of progression. In patients with multiple HCAs, hepatocyte nuclear factor 1α-inactivated HCAs showed a higher rate of progression compared with inflammatory HCAs (11 of 26 [42%] vs seven of 37 [19%],
= .04) despite lower use (28 of 32 patients [88%] vs 45 of 45 patients [100%];
= .03) and shorter duration (mean, 12.0 years ± 7.5 vs 19.2 years ± 9.2;
= .001) of oral contraceptive intake. Conclusion Long-term MRI follow-up showed that 78% of hepatocellular adenomas had long-term stability or regression. After resection of solitary hepatocellular adenomas, new lesions occurred only in hepatocellular adenomas at risk of progression. Patients with multiple hepatocellular adenomas were more likely to show progressive disease, with hepatic nuclear factor 1α-inactivated hepatocellular adenomas being the most common subtype showing progression. © RSNA, 2020</description><subject>Adenoma, Liver Cell - diagnostic imaging</subject><subject>Adenoma, Liver Cell - pathology</subject><subject>Adult</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - pathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Response Evaluation Criteria in Solid Tumors</subject><subject>Retrospective Studies</subject><issn>0033-8419</issn><issn>1527-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFLwzAcxYMobk4_gBfJ0Utn_knTJicZY3ODiSB6DmmaSiVtatIqfns7NvX0Lu893vshdA1kDpCKu6DL2rs5JZSAhFySEzQFTvMEGPBTNCWEsUSkICfoIsZ3QiDlIj9HE0ZBQE7FFN3vfPuW9DY0ePXp3dDXvsW-whvb6d4b69zgdMCL0ra-0RHrHj8-b_HaO-e_kqG7RGeVdtFeHXWGXterl-Um2T09bJeLXWJSIH3CqIaS21JUBTeU6FIazYtxRKZllUEFaVYIbaQtWGmqjDFGJQMznkkF4SxjM3R76O2C_xhs7FVTx_083Vo_REVZnksJwOVohYPVBB9jsJXqQt3o8K2AqD03deCm_rmNmZtj_VA0tvxL_IJiP9RsaOw</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Vernuccio, Federica</creator><creator>Ronot, Maxime</creator><creator>Dioguardi Burgio, Marco</creator><creator>Cauchy, François</creator><creator>Choudhury, Kingshuk R</creator><creator>Dokmak, Safi</creator><creator>Soubrane, Olivier</creator><creator>Valla, Dominique</creator><creator>Zucman-Rossi, Jessica</creator><creator>Paradis, Valérie</creator><creator>Vilgrain, Valérie</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7464-3939</orcidid><orcidid>https://orcid.org/0000-0002-3243-6699</orcidid><orcidid>https://orcid.org/0000-0002-4460-7643</orcidid><orcidid>https://orcid.org/0000-0002-3568-7725</orcidid><orcidid>https://orcid.org/0000-0002-0306-2915</orcidid><orcidid>https://orcid.org/0000-0002-4997-3730</orcidid><orcidid>https://orcid.org/0000-0003-0350-1794</orcidid><orcidid>https://orcid.org/0000-0002-3335-4388</orcidid></search><sort><creationdate>202005</creationdate><title>Long-term Evolution of Hepatocellular Adenomas at MRI Follow-up</title><author>Vernuccio, Federica ; Ronot, Maxime ; Dioguardi Burgio, Marco ; Cauchy, François ; Choudhury, Kingshuk R ; Dokmak, Safi ; Soubrane, Olivier ; Valla, Dominique ; Zucman-Rossi, Jessica ; Paradis, Valérie ; Vilgrain, Valérie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-32a1d5ed8fb5c20ad9ca5b1816a9f61f146b8ac9eb3dcf63332931c1524805363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adenoma, Liver Cell - diagnostic imaging</topic><topic>Adenoma, Liver Cell - pathology</topic><topic>Adult</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - pathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Response Evaluation Criteria in Solid Tumors</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vernuccio, Federica</creatorcontrib><creatorcontrib>Ronot, Maxime</creatorcontrib><creatorcontrib>Dioguardi Burgio, Marco</creatorcontrib><creatorcontrib>Cauchy, François</creatorcontrib><creatorcontrib>Choudhury, Kingshuk R</creatorcontrib><creatorcontrib>Dokmak, Safi</creatorcontrib><creatorcontrib>Soubrane, Olivier</creatorcontrib><creatorcontrib>Valla, Dominique</creatorcontrib><creatorcontrib>Zucman-Rossi, Jessica</creatorcontrib><creatorcontrib>Paradis, Valérie</creatorcontrib><creatorcontrib>Vilgrain, Valérie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vernuccio, Federica</au><au>Ronot, Maxime</au><au>Dioguardi Burgio, Marco</au><au>Cauchy, François</au><au>Choudhury, Kingshuk R</au><au>Dokmak, Safi</au><au>Soubrane, Olivier</au><au>Valla, Dominique</au><au>Zucman-Rossi, Jessica</au><au>Paradis, Valérie</au><au>Vilgrain, Valérie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term Evolution of Hepatocellular Adenomas at MRI Follow-up</atitle><jtitle>Radiology</jtitle><addtitle>Radiology</addtitle><date>2020-05</date><risdate>2020</risdate><volume>295</volume><issue>2</issue><spage>361</spage><epage>372</epage><pages>361-372</pages><issn>0033-8419</issn><eissn>1527-1315</eissn><abstract>Background Hepatocellular adenomas (HCAs) are rare benign liver tumors. Guidelines recommend continued surveillance of patients diagnosed with HCAs, but these guidelines are mainly based on small studies or expert opinion. Purpose To analyze the long-term evolution of HCAs, including solitary and multiple lesions, and to identify predictive features of progression with MRI. Materials and Methods In a retrospective study, patients diagnosed with pathologically proven solitary or multiple HCAs between January 2004 and December 2015 were included; β-catenin-mutated HCAs and HCAs with foci of malignancy were considered to be at risk for progression. MRI examinations were analyzed, and tumor evolution was evaluated by using Response Evaluation Criteria in Solid Tumors, version 1.1. Student
Mann-Whitney, χ
, Fisher exact, and McNemar tests were used, as appropriate. Results In total, 118 patients (mean age, 40 years ± 10 [standard deviation]; 108 women) were evaluated, including 41 with a solitary HCA (mean age, 40 years ± 14; 36 women) and 77 with multiple HCAs (mean age, 40 years ± 10; 72 women). At a median follow-up of 5 years, 37 of 41 (90%) patients with a solitary HCA and 55 of 77 (71%) patients with multiple HCAs showed stable or regressive disease. After resection of solitary HCAs, new lesions appeared in only two of 29 (7%) patients, both of whom had HCAs at risk of progression. In patients with multiple HCAs, hepatocyte nuclear factor 1α-inactivated HCAs showed a higher rate of progression compared with inflammatory HCAs (11 of 26 [42%] vs seven of 37 [19%],
= .04) despite lower use (28 of 32 patients [88%] vs 45 of 45 patients [100%];
= .03) and shorter duration (mean, 12.0 years ± 7.5 vs 19.2 years ± 9.2;
= .001) of oral contraceptive intake. Conclusion Long-term MRI follow-up showed that 78% of hepatocellular adenomas had long-term stability or regression. After resection of solitary hepatocellular adenomas, new lesions occurred only in hepatocellular adenomas at risk of progression. Patients with multiple hepatocellular adenomas were more likely to show progressive disease, with hepatic nuclear factor 1α-inactivated hepatocellular adenomas being the most common subtype showing progression. © RSNA, 2020</abstract><cop>United States</cop><pmid>32181728</pmid><doi>10.1148/radiol.2020191790</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7464-3939</orcidid><orcidid>https://orcid.org/0000-0002-3243-6699</orcidid><orcidid>https://orcid.org/0000-0002-4460-7643</orcidid><orcidid>https://orcid.org/0000-0002-3568-7725</orcidid><orcidid>https://orcid.org/0000-0002-0306-2915</orcidid><orcidid>https://orcid.org/0000-0002-4997-3730</orcidid><orcidid>https://orcid.org/0000-0003-0350-1794</orcidid><orcidid>https://orcid.org/0000-0002-3335-4388</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Radiological Society of North America; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenoma, Liver Cell - diagnostic imaging Adenoma, Liver Cell - pathology Adult Disease Progression Female Humans Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Magnetic Resonance Imaging - methods Male Response Evaluation Criteria in Solid Tumors Retrospective Studies |
| title | Long-term Evolution of Hepatocellular Adenomas at MRI Follow-up |
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