A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL

[Display omitted] Transcriptional coactivators p300 and CBP catalyze the acetylation of lysine residues in histone proteins. Upregulation of p300 and CBP has been associated with lung, colorectal and hepatocellular cancer, indicating an important role of p300 and CBP in tumorigenesis. Recently, the...

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Veröffentlicht in:	Biochemical pharmacology 2020-05, Vol.175, p.113914-113914, Article 113914
Hauptverfasser:	Zhang, Baojie, Chen, Deng, Liu, Bin, Dekker, Frank J., Quax, Wim J.
Format:	Artikel
Sprache:	eng
Schlagworte:	EGFR-TKI-resistant cells Histone acetylation Histone acetyltransferase inhibitor Non-small-cell lung cancer TRAIL
Online-Zugang:	Volltext
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