Design, synthesis and biological evaluation of 4-(pyridin-4-yloxy)benzamide derivatives bearing a 5-methylpyridazin-3(2H)-one fragment

[Display omitted] A series of 4-(pyridin-4-yloxy)benzamide derivatives bearing a 5-methylpyridazin-3(2H)-one fragment were designed, synthesized, and evaluated for their biological activity. Most compounds showed effective inhibitory activity against cancer cell lines of A549, HeLa and MCF-7. Among...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2020-05, Vol.30 (9), p.127076-127076, Article 127076
Hauptverfasser:	Xiong, Hehua, Zhang, Jianqing, Zhang, Qian, Duan, Yongli, Zhang, Han, Zheng, Pengwu, Tang, Qidong
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(Pyridin-4-yloxy)benzamide derivatives 5-Methylpyridazin-3(2H)-one Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzamides - chemical synthesis Benzamides - chemistry Benzamides - pharmacology c-Met Catalytic Domain Cell Line, Tumor Cell Survival Drug Design Humans Inhibitors Inhibitory Concentration 50 Models, Molecular Molecular Structure Protein Conformation Proto-Oncogene Proteins c-met - chemistry Structure-Activity Relationship Synthesis
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