Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression

•LPS induced despair-like behavior, anhedonia and impaired motivation/self-care.•The ADs, AMI (tricyclic), ESC (SSRI), TCP (MAOI) and VORT (multimodal drug) prevented despair-like behavior.•Only VORT rescued impaired self-care behavior.•All ADs prevented LPS-induced rise of brain pro-inflammatory cy...

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Veröffentlicht in:	Journal of affective disorders 2020-05, Vol.268, p.188-200
Hauptverfasser:	Tomaz, Viviane de Sousa, Chaves Filho, Adriano José Maia, Cordeiro, Rafaela Carneiro, Jucá, Paloma Marinho, Soares, Michelle Verde Ramo, Barroso, Poliana Noronha, Cristino, Larissa Maria Frota, Jiang, Wei, Teixeira, Antônio Lúcio, de Lucena, David F., Macedo, Danielle S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antidepressants Antidepressive Agents - pharmacology Brain - metabolism Citalopram - pharmacology Corticosterone - blood Cytokines Cytokines - metabolism Depression Depression - prevention & control Hippocampus - metabolism Humans Interferon-gamma - metabolism Interleukin-1beta - metabolism Lipopolysaccharide Lipopolysaccharides Male Mice Neuroinflammation Rats Serotonin Uptake Inhibitors - pharmacology Tumor Necrosis Factor-alpha - metabolism Vortioxetine
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