Reasons for guideline non-adherence in older and younger women with advanced stage ovarian cancer
This study aims to assess the reasons for guideline non-adherence in women with advanced stage ovarian cancer and whether these reasons differ according to age. All women diagnosed with advanced stage ovarian cancer, International Federation of Gynecology and Obstetrics (FIGO) IIb–IV, between 2015 a...
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| Veröffentlicht in: | Gynecologic oncology 2020-06, Vol.157 (3), p.593-598 |
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| container_title | Gynecologic oncology |
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| creator | van Walree, I.C. Bretveld, R. van Huis-Tanja, L.H. Louwers, J.A. Emmelot-Vonk, M.H. Hamaker, M.E. |
| description | This study aims to assess the reasons for guideline non-adherence in women with advanced stage ovarian cancer and whether these reasons differ according to age.
All women diagnosed with advanced stage ovarian cancer, International Federation of Gynecology and Obstetrics (FIGO) IIb–IV, between 2015 and 2018 were selected from the Netherlands Cancer Registry. Treatment patterns and reasons for guideline non-adherence were analyzed according to age groups.
4210 women were included, of whom 34%, 33%, 26%, and 8% were aged |
| doi_str_mv | 10.1016/j.ygyno.2020.03.005 |
| format | Article |
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All women diagnosed with advanced stage ovarian cancer, International Federation of Gynecology and Obstetrics (FIGO) IIb–IV, between 2015 and 2018 were selected from the Netherlands Cancer Registry. Treatment patterns and reasons for guideline non-adherence were analyzed according to age groups.
4210 women were included, of whom 34%, 33%, 26%, and 8% were aged <65, 65–75, 75–85, and ≥85 years respectively. With advancing age, less women received guideline-adherent treatment (decreasing from 70% to 2% in women aged <65 and ≥85 years respectively) and more women received best supportive care only (ranging from 4% to 69% in women aged <65 and ≥85 years respectively). The most prevalent reasons for guideline non-adherence differed according to age and included patient preference in older women, and functional status and extent of disease in younger women.
Most older women did not receive guideline-adherent care and patient preference was the most common reason for this decision. This knowledge provides insight in the current treatment decision-making process and highlights the importance of eliciting patient treatment preferences. Further prospective research is necessary to study the underlying motivation for women to decline guideline care and the extent to which shared decision-making influences treatment choice.
•Older women with advanced stage ovarian cancer receive guideline-adherent treatment less often than younger women.•Compared to their younger counterparts, older women are less frequently discussed in a multidisciplinary team meeting.•In younger women, functional status and extent of disease were the main reasons for guideline non-adherence.•In older women, patient preference was the most important reason for guideline non-adherent care.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/j.ygyno.2020.03.005</identifier><identifier>PMID: 32171566</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Female ; Guideline adherence ; Guideline Adherence - standards ; Humans ; Neoplasm Staging ; Older patients ; Ovarian cancer ; Ovarian Neoplasms - therapy ; Reasons ; Treatment patterns</subject><ispartof>Gynecologic oncology, 2020-06, Vol.157 (3), p.593-598</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-e48bc293694ccb297a682a49f186005ecd9838254395b728c2105b78525cf11d3</citedby><cites>FETCH-LOGICAL-c359t-e48bc293694ccb297a682a49f186005ecd9838254395b728c2105b78525cf11d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0090825820302213$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32171566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Walree, I.C.</creatorcontrib><creatorcontrib>Bretveld, R.</creatorcontrib><creatorcontrib>van Huis-Tanja, L.H.</creatorcontrib><creatorcontrib>Louwers, J.A.</creatorcontrib><creatorcontrib>Emmelot-Vonk, M.H.</creatorcontrib><creatorcontrib>Hamaker, M.E.</creatorcontrib><title>Reasons for guideline non-adherence in older and younger women with advanced stage ovarian cancer</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>This study aims to assess the reasons for guideline non-adherence in women with advanced stage ovarian cancer and whether these reasons differ according to age.
All women diagnosed with advanced stage ovarian cancer, International Federation of Gynecology and Obstetrics (FIGO) IIb–IV, between 2015 and 2018 were selected from the Netherlands Cancer Registry. Treatment patterns and reasons for guideline non-adherence were analyzed according to age groups.
4210 women were included, of whom 34%, 33%, 26%, and 8% were aged <65, 65–75, 75–85, and ≥85 years respectively. With advancing age, less women received guideline-adherent treatment (decreasing from 70% to 2% in women aged <65 and ≥85 years respectively) and more women received best supportive care only (ranging from 4% to 69% in women aged <65 and ≥85 years respectively). The most prevalent reasons for guideline non-adherence differed according to age and included patient preference in older women, and functional status and extent of disease in younger women.
Most older women did not receive guideline-adherent care and patient preference was the most common reason for this decision. This knowledge provides insight in the current treatment decision-making process and highlights the importance of eliciting patient treatment preferences. Further prospective research is necessary to study the underlying motivation for women to decline guideline care and the extent to which shared decision-making influences treatment choice.
•Older women with advanced stage ovarian cancer receive guideline-adherent treatment less often than younger women.•Compared to their younger counterparts, older women are less frequently discussed in a multidisciplinary team meeting.•In younger women, functional status and extent of disease were the main reasons for guideline non-adherence.•In older women, patient preference was the most important reason for guideline non-adherent care.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Guideline adherence</subject><subject>Guideline Adherence - standards</subject><subject>Humans</subject><subject>Neoplasm Staging</subject><subject>Older patients</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - therapy</subject><subject>Reasons</subject><subject>Treatment patterns</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9vFCEYh4mxsWv1E5gYjl5mfIFlgIMH09hq0sSk0TNh4Z0tm1moMLPNfntZt3r0xBvyvH9-DyHvGPQM2PBx1x-3x5R7Dhx6ED2AfEFWDIzsBi3NS7ICMNBpLvUleV3rDgAEMP6KXArOFJPDsCLuHl3NqdIxF7pdYsApJqQpp86FByyYPNKYaJ4CFupSoMe8pG2rn_IeE32K8wN14eAaF2id3RZpPrgSXaL-9FnekIvRTRXfPr9X5OfNlx_XX7u777ffrj_fdV5IM3e41hvPjRjM2vsNN8oNmru1GZkeWjL0wWjRsqyFkRvFtecMWqEll35kLIgr8uE897HkXwvW2e5j9ThNLmFequVCqUEpqVRDxRn1JddacLSPJe5dOVoG9uTW7uwft_bk1oKw7YLW9f55wbLZY_jX81dmAz6dAWwxDxGLrT6eBIZY0M825PjfBb8BV_2Llg</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>van Walree, I.C.</creator><creator>Bretveld, R.</creator><creator>van Huis-Tanja, L.H.</creator><creator>Louwers, J.A.</creator><creator>Emmelot-Vonk, M.H.</creator><creator>Hamaker, M.E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202006</creationdate><title>Reasons for guideline non-adherence in older and younger women with advanced stage ovarian cancer</title><author>van Walree, I.C. ; Bretveld, R. ; van Huis-Tanja, L.H. ; Louwers, J.A. ; Emmelot-Vonk, M.H. ; Hamaker, M.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-e48bc293694ccb297a682a49f186005ecd9838254395b728c2105b78525cf11d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Guideline adherence</topic><topic>Guideline Adherence - standards</topic><topic>Humans</topic><topic>Neoplasm Staging</topic><topic>Older patients</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - therapy</topic><topic>Reasons</topic><topic>Treatment patterns</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Walree, I.C.</creatorcontrib><creatorcontrib>Bretveld, R.</creatorcontrib><creatorcontrib>van Huis-Tanja, L.H.</creatorcontrib><creatorcontrib>Louwers, J.A.</creatorcontrib><creatorcontrib>Emmelot-Vonk, M.H.</creatorcontrib><creatorcontrib>Hamaker, M.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Walree, I.C.</au><au>Bretveld, R.</au><au>van Huis-Tanja, L.H.</au><au>Louwers, J.A.</au><au>Emmelot-Vonk, M.H.</au><au>Hamaker, M.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reasons for guideline non-adherence in older and younger women with advanced stage ovarian cancer</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2020-06</date><risdate>2020</risdate><volume>157</volume><issue>3</issue><spage>593</spage><epage>598</epage><pages>593-598</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><abstract>This study aims to assess the reasons for guideline non-adherence in women with advanced stage ovarian cancer and whether these reasons differ according to age.
All women diagnosed with advanced stage ovarian cancer, International Federation of Gynecology and Obstetrics (FIGO) IIb–IV, between 2015 and 2018 were selected from the Netherlands Cancer Registry. Treatment patterns and reasons for guideline non-adherence were analyzed according to age groups.
4210 women were included, of whom 34%, 33%, 26%, and 8% were aged <65, 65–75, 75–85, and ≥85 years respectively. With advancing age, less women received guideline-adherent treatment (decreasing from 70% to 2% in women aged <65 and ≥85 years respectively) and more women received best supportive care only (ranging from 4% to 69% in women aged <65 and ≥85 years respectively). The most prevalent reasons for guideline non-adherence differed according to age and included patient preference in older women, and functional status and extent of disease in younger women.
Most older women did not receive guideline-adherent care and patient preference was the most common reason for this decision. This knowledge provides insight in the current treatment decision-making process and highlights the importance of eliciting patient treatment preferences. Further prospective research is necessary to study the underlying motivation for women to decline guideline care and the extent to which shared decision-making influences treatment choice.
•Older women with advanced stage ovarian cancer receive guideline-adherent treatment less often than younger women.•Compared to their younger counterparts, older women are less frequently discussed in a multidisciplinary team meeting.•In younger women, functional status and extent of disease were the main reasons for guideline non-adherence.•In older women, patient preference was the most important reason for guideline non-adherent care.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32171566</pmid><doi>10.1016/j.ygyno.2020.03.005</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Aged, 80 and over Female Guideline adherence Guideline Adherence - standards Humans Neoplasm Staging Older patients Ovarian cancer Ovarian Neoplasms - therapy Reasons Treatment patterns |
| title | Reasons for guideline non-adherence in older and younger women with advanced stage ovarian cancer |
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