TERT promoter mutations and telomeres during tumorigenesis

Telomerase regulation and telomere shortening act as a strong tumor suppressor mechanism in human somatic cells. Point mutations in the promoter of telomerase reverse transcriptase (TERT) are the most frequent non-coding mutation in cancer. These TERT promoter mutations (TPMs) create de novo ETS fac...

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Veröffentlicht in:	Current opinion in genetics & development 2020-02, Vol.60, p.56-62
Hauptverfasser:	Lorbeer, Franziska K, Hockemeyer, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology DNA Methylation Gene Expression Regulation, Neoplastic Humans Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Promoter Regions, Genetic Telomerase - genetics Telomere Telomere Homeostasis
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