Construction of a sensitive electrochemical sensor based on 1T-MoS2 nanosheets decorated with shape-controlled gold nanostructures for the voltammetric determination of doxorubicin
An innovative and portable design to fabricate an electrochemical sensor based on metallic phase MoS 2 (1T-MoS 2 ) decorated with shape-dependent gold nanostructures for the determination of doxorubicin (DOX) is presented. In this context, homogenous and uniform single-crystal gold nanospheres (AuNS...
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| Veröffentlicht in: | Mikrochimica acta (1966) 2020-04, Vol.187 (4), p.223-223, Article 223 |
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| creator | Er, Engin Erk, Nevin |
| description | An innovative and portable design to fabricate an electrochemical sensor based on metallic phase MoS
2
(1T-MoS
2
) decorated with shape-dependent gold nanostructures for the determination of doxorubicin (DOX) is presented. In this context, homogenous and uniform single-crystal gold nanospheres (AuNSPs) and nanorods (AuNRDs) were firstly synthesized by seeded growth approach. Afterwards, AuNSPs and AuNRDs were anchored on 1T-MoS
2
surfaces to construct the desired electrochemical sensing platform towards the DOX assay. 1T-MoS
2
was exfoliated by metal intercalation process using NaK metal alloys. The structure and surface morphology of 1T-MoS
2
, AuNSPs, and AuNRDs were characterized by XPS, Raman, UV-vis, TEM, and SEM. The electrochemical behavior of DOX using various MoS
2
-based electrochemical sensors prepared on screen-printed electrode (SPE) was examined by cyclic voltammetry and adsorptive stripping differential pulse voltammetry. The electrocatalytic efficiency of AuNRDs on 1T-MoS
2
was also compared with that of AuNSPs on 1T-MoS
2
, and it showed much better electrocatalytic activity towards the DOX. A nanocomposite prepared with AuNRDs and 1T-MoS
2
on SPE (AuNRDs/1T-MoS
2
/SPE) exhibited a linear relationship between peak current and DOX concentration in the range 0.01–9.5 μM with a detection limit of 2.5 nM. The AuNRDs/1T-MoS
2
/SPE was successfully applied to the sensitive and rapid determination of DOX in spiked human serum samples with satisfactory recoveries in the range 99.2–100.8%.
Graphical abstract
Schematic representation of a portable design for electrochemical sensor based on shape-controlled gold nanostructures decorated on metallic phase molybdenum disulfide (1T-MoS
2
) towards the sensitive determination of doxorubicin. |
| doi_str_mv | 10.1007/s00604-020-4206-y |
| format | Article |
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2
(1T-MoS
2
) decorated with shape-dependent gold nanostructures for the determination of doxorubicin (DOX) is presented. In this context, homogenous and uniform single-crystal gold nanospheres (AuNSPs) and nanorods (AuNRDs) were firstly synthesized by seeded growth approach. Afterwards, AuNSPs and AuNRDs were anchored on 1T-MoS
2
surfaces to construct the desired electrochemical sensing platform towards the DOX assay. 1T-MoS
2
was exfoliated by metal intercalation process using NaK metal alloys. The structure and surface morphology of 1T-MoS
2
, AuNSPs, and AuNRDs were characterized by XPS, Raman, UV-vis, TEM, and SEM. The electrochemical behavior of DOX using various MoS
2
-based electrochemical sensors prepared on screen-printed electrode (SPE) was examined by cyclic voltammetry and adsorptive stripping differential pulse voltammetry. The electrocatalytic efficiency of AuNRDs on 1T-MoS
2
was also compared with that of AuNSPs on 1T-MoS
2
, and it showed much better electrocatalytic activity towards the DOX. A nanocomposite prepared with AuNRDs and 1T-MoS
2
on SPE (AuNRDs/1T-MoS
2
/SPE) exhibited a linear relationship between peak current and DOX concentration in the range 0.01–9.5 μM with a detection limit of 2.5 nM. The AuNRDs/1T-MoS
2
/SPE was successfully applied to the sensitive and rapid determination of DOX in spiked human serum samples with satisfactory recoveries in the range 99.2–100.8%.
Graphical abstract
Schematic representation of a portable design for electrochemical sensor based on shape-controlled gold nanostructures decorated on metallic phase molybdenum disulfide (1T-MoS
2
) towards the sensitive determination of doxorubicin.</description><identifier>ISSN: 0026-3672</identifier><identifier>EISSN: 1436-5073</identifier><identifier>DOI: 10.1007/s00604-020-4206-y</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adsorptivity ; Analytical Chemistry ; Characterization and Evaluation of Materials ; Chemical sensors ; Chemistry ; Chemistry and Materials Science ; Doxorubicin ; Electrochemical analysis ; Gold ; Microengineering ; Molybdenum disulfide ; Morphology ; Nanochemistry ; Nanocomposites ; Nanorods ; Nanosheets ; Nanospheres ; Nanostructure ; Nanotechnology ; Original Paper ; Single crystals ; Voltammetry ; X ray photoelectron spectroscopy</subject><ispartof>Mikrochimica acta (1966), 2020-04, Vol.187 (4), p.223-223, Article 223</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-4d4c9f23dc8966e74d48e7997deaddbacb5d15aa6b9af4c2bd17e7ad641485563</citedby><cites>FETCH-LOGICAL-c349t-4d4c9f23dc8966e74d48e7997deaddbacb5d15aa6b9af4c2bd17e7ad641485563</cites><orcidid>0000-0002-7713-3704</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00604-020-4206-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00604-020-4206-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Er, Engin</creatorcontrib><creatorcontrib>Erk, Nevin</creatorcontrib><title>Construction of a sensitive electrochemical sensor based on 1T-MoS2 nanosheets decorated with shape-controlled gold nanostructures for the voltammetric determination of doxorubicin</title><title>Mikrochimica acta (1966)</title><addtitle>Microchim Acta</addtitle><description>An innovative and portable design to fabricate an electrochemical sensor based on metallic phase MoS
2
(1T-MoS
2
) decorated with shape-dependent gold nanostructures for the determination of doxorubicin (DOX) is presented. In this context, homogenous and uniform single-crystal gold nanospheres (AuNSPs) and nanorods (AuNRDs) were firstly synthesized by seeded growth approach. Afterwards, AuNSPs and AuNRDs were anchored on 1T-MoS
2
surfaces to construct the desired electrochemical sensing platform towards the DOX assay. 1T-MoS
2
was exfoliated by metal intercalation process using NaK metal alloys. The structure and surface morphology of 1T-MoS
2
, AuNSPs, and AuNRDs were characterized by XPS, Raman, UV-vis, TEM, and SEM. The electrochemical behavior of DOX using various MoS
2
-based electrochemical sensors prepared on screen-printed electrode (SPE) was examined by cyclic voltammetry and adsorptive stripping differential pulse voltammetry. The electrocatalytic efficiency of AuNRDs on 1T-MoS
2
was also compared with that of AuNSPs on 1T-MoS
2
, and it showed much better electrocatalytic activity towards the DOX. A nanocomposite prepared with AuNRDs and 1T-MoS
2
on SPE (AuNRDs/1T-MoS
2
/SPE) exhibited a linear relationship between peak current and DOX concentration in the range 0.01–9.5 μM with a detection limit of 2.5 nM. The AuNRDs/1T-MoS
2
/SPE was successfully applied to the sensitive and rapid determination of DOX in spiked human serum samples with satisfactory recoveries in the range 99.2–100.8%.
Graphical abstract
Schematic representation of a portable design for electrochemical sensor based on shape-controlled gold nanostructures decorated on metallic phase molybdenum disulfide (1T-MoS
2
) towards the sensitive determination of doxorubicin.</description><subject>Adsorptivity</subject><subject>Analytical Chemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical sensors</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Doxorubicin</subject><subject>Electrochemical analysis</subject><subject>Gold</subject><subject>Microengineering</subject><subject>Molybdenum disulfide</subject><subject>Morphology</subject><subject>Nanochemistry</subject><subject>Nanocomposites</subject><subject>Nanorods</subject><subject>Nanosheets</subject><subject>Nanospheres</subject><subject>Nanostructure</subject><subject>Nanotechnology</subject><subject>Original Paper</subject><subject>Single crystals</subject><subject>Voltammetry</subject><subject>X ray photoelectron spectroscopy</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kU1rFTEUhgex4LX6A9wF3LiJ5muSm6Vc_IKKi7brkEnOdFJmkmuSqd7_1R9o2lEEwVVIzvM-OfB23StK3lJC1LtCiCQCE0awYETi05NuRwWXuCeKP-12hDCJuVTsWfe8lFtCqJJM7Lr7Q4ql5tXVkCJKI7KoQCyhhjtAMIOrObkJluDs_DhJGQ22gEcNp1f4a7pkKNqYygRQC_LgUra1zX-EOqEy2SNgl2LTzHN7vUmz3_jHT9cMBY3NWSdAd2mudlmg5uCaqEJeQrR_FvPpZ8rrEFyIL7qz0c4FXv4-z7vrjx-uDp_xxbdPXw7vL7DjQlcsvHB6ZNy7vZYSVLvvQWmtPFjvB-uG3tPeWjloOwrHBk8VKOuloGLf95Kfd2827zGn7yuUapZQHMyzjZDWYhhXigshtG7o63_Q27Tm2LZrlGY93zNNGkU3yuVUSobRHHNYbD4ZSsxDj2br0bQezUOP5tQybMuUxsYbyH_N_w_9AhxEpqY</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Er, Engin</creator><creator>Erk, Nevin</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7713-3704</orcidid></search><sort><creationdate>20200401</creationdate><title>Construction of a sensitive electrochemical sensor based on 1T-MoS2 nanosheets decorated with shape-controlled gold nanostructures for the voltammetric determination of doxorubicin</title><author>Er, Engin ; Erk, Nevin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-4d4c9f23dc8966e74d48e7997deaddbacb5d15aa6b9af4c2bd17e7ad641485563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adsorptivity</topic><topic>Analytical Chemistry</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemical sensors</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Doxorubicin</topic><topic>Electrochemical analysis</topic><topic>Gold</topic><topic>Microengineering</topic><topic>Molybdenum disulfide</topic><topic>Morphology</topic><topic>Nanochemistry</topic><topic>Nanocomposites</topic><topic>Nanorods</topic><topic>Nanosheets</topic><topic>Nanospheres</topic><topic>Nanostructure</topic><topic>Nanotechnology</topic><topic>Original Paper</topic><topic>Single crystals</topic><topic>Voltammetry</topic><topic>X ray photoelectron spectroscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Er, Engin</creatorcontrib><creatorcontrib>Erk, Nevin</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Er, Engin</au><au>Erk, Nevin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Construction of a sensitive electrochemical sensor based on 1T-MoS2 nanosheets decorated with shape-controlled gold nanostructures for the voltammetric determination of doxorubicin</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><date>2020-04-01</date><risdate>2020</risdate><volume>187</volume><issue>4</issue><spage>223</spage><epage>223</epage><pages>223-223</pages><artnum>223</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>An innovative and portable design to fabricate an electrochemical sensor based on metallic phase MoS
2
(1T-MoS
2
) decorated with shape-dependent gold nanostructures for the determination of doxorubicin (DOX) is presented. In this context, homogenous and uniform single-crystal gold nanospheres (AuNSPs) and nanorods (AuNRDs) were firstly synthesized by seeded growth approach. Afterwards, AuNSPs and AuNRDs were anchored on 1T-MoS
2
surfaces to construct the desired electrochemical sensing platform towards the DOX assay. 1T-MoS
2
was exfoliated by metal intercalation process using NaK metal alloys. The structure and surface morphology of 1T-MoS
2
, AuNSPs, and AuNRDs were characterized by XPS, Raman, UV-vis, TEM, and SEM. The electrochemical behavior of DOX using various MoS
2
-based electrochemical sensors prepared on screen-printed electrode (SPE) was examined by cyclic voltammetry and adsorptive stripping differential pulse voltammetry. The electrocatalytic efficiency of AuNRDs on 1T-MoS
2
was also compared with that of AuNSPs on 1T-MoS
2
, and it showed much better electrocatalytic activity towards the DOX. A nanocomposite prepared with AuNRDs and 1T-MoS
2
on SPE (AuNRDs/1T-MoS
2
/SPE) exhibited a linear relationship between peak current and DOX concentration in the range 0.01–9.5 μM with a detection limit of 2.5 nM. The AuNRDs/1T-MoS
2
/SPE was successfully applied to the sensitive and rapid determination of DOX in spiked human serum samples with satisfactory recoveries in the range 99.2–100.8%.
Graphical abstract
Schematic representation of a portable design for electrochemical sensor based on shape-controlled gold nanostructures decorated on metallic phase molybdenum disulfide (1T-MoS
2
) towards the sensitive determination of doxorubicin.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><doi>10.1007/s00604-020-4206-y</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7713-3704</orcidid></addata></record> |
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| issn | 0026-3672 1436-5073 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Adsorptivity Analytical Chemistry Characterization and Evaluation of Materials Chemical sensors Chemistry Chemistry and Materials Science Doxorubicin Electrochemical analysis Gold Microengineering Molybdenum disulfide Morphology Nanochemistry Nanocomposites Nanorods Nanosheets Nanospheres Nanostructure Nanotechnology Original Paper Single crystals Voltammetry X ray photoelectron spectroscopy |
| title | Construction of a sensitive electrochemical sensor based on 1T-MoS2 nanosheets decorated with shape-controlled gold nanostructures for the voltammetric determination of doxorubicin |
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