Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma

Diffuse intrinsic pontine glioma (DIPG) is an incurable type of pediatric brain cancer, which in the majority of cases is driven by mutations in genes encoding histone 3 (H3K27M). We here determined the preclinical therapeutic potential of combined AXL and HDAC inhibition in these tumors to reverse...

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Veröffentlicht in:	Clinical cancer research 2020-07, Vol.26 (13), p.3319-3332
Hauptverfasser:	Meel, Michaël H, de Gooijer, Mark C, Metselaar, Dennis S, Sewing, A Charlotte P, Zwaan, Kenn, Waranecki, Piotr, Breur, Marjolein, Buil, Levi C M, Lagerweij, Tonny, Wedekind, Laurine E, Twisk, Jos W R, Koster, Jan, Hashizume, Rintaro, Raabe, Eric H, Montero Carcaboso, Ángel, Bugiani, Marianna, Phoenix, Timothy N, van Tellingen, Olaf, van Vuurden, Dannis G, Kaspers, Gertjan J L, Hulleman, Esther
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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