Hypothalamus-pituitary-adrenal axis imbalance and inflammation contribute to sex differences in separation- and restraint-induced depression

Whether social contact contributes to the underlying mechanisms of depression and the observed sex differences is unclear. In this study, we subjected young male and female mice to separation- and restraint-induced stress for 4 weeks and assessed behaviors, neurotransmitter levels, hormones, and inf...

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Veröffentlicht in:	Hormones and behavior 2020-06, Vol.122, p.104741-104741, Article 104741
Hauptverfasser:	Dong, Yinfeng, Wang, Xuyang, Zhou, Yan, Zheng, Qiaomu, Chen, Zheng, Zhang, Hua, Sun, Zhiling, Xu, Guihua, Hu, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety, Separation - complications Anxiety, Separation - physiopathology Anxiety, Separation - psychology Corticosterone - blood Depression - etiology Depression - physiopathology Female HPA axis Hypothalamo-Hypophyseal System - physiopathology Inflammation Inflammation - physiopathology Inflammation - psychology Male Mice Mice, Inbred C57BL Pituitary-Adrenal System - physiopathology Restraint stress Restraint, Physical - physiology Restraint, Physical - psychology Sex Characteristics Sex difference Social Isolation - psychology Stress, Psychological - complications Stress, Psychological - physiopathology Stress, Psychological - psychology Swimming
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