Comparison of diagnostic performance of non-contrast MRI and abbreviated MRI using gadoxetic acid in initially diagnosed hepatocellular carcinoma patients: a simulation study of surveillance for hepatocellular carcinomas
Objective This study was conducted in order to compare the diagnostic performance of noncontrast and abbreviated MRI using gadoxetic acid for detecting hepatocellular carcinoma (HCC) in initially diagnosed HCC patients. Methods We identified 140 consecutive patients with newly diagnosed HCC (173 HCC...
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| Veröffentlicht in: | European radiology 2020-08, Vol.30 (8), p.4150-4163 |
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| creator | Whang, Sunyoung Choi, Moon Hyung Choi, Joon-Il Youn, Seo Yeon Kim, Dong Hwan Rha, Sung Eun |
| description | Objective
This study was conducted in order to compare the diagnostic performance of noncontrast and abbreviated MRI using gadoxetic acid for detecting hepatocellular carcinoma (HCC) in initially diagnosed HCC patients.
Methods
We identified 140 consecutive patients with newly diagnosed HCC (173 HCCs) within the Milan criteria, who underwent liver MRI using gadoxetic acid between 2015 and 2016. One hundred twenty-three consecutive patients without HCC who underwent liver MRI in the same period for HCC surveillance were enrolled for the control group. Two radiologists independently reviewed two MRI sets: a noncontrast set and an abbreviated set. The noncontrast set consists of T2 FSE/ssFSE, T1 in- and out-of-phase image, DWI, and the ADC map. The abbreviated set consists of T2 FSE/ssFSE, hepatobiliary phase image 20 min after gadoxetic acid injection, DWI, and the ADC map.
Results
In a per-patient analysis, sensitivity of reviewer 1 for noncontrast and abbreviated sets was 85.7 and 90.0%, respectively. The specificity for both noncontrast and abbreviated sets was 92.7%. For reviewer 2, sensitivity of noncontrast and abbreviated sets was 86.4 and 89.3%, respectively. Per-patient specificity of reviewer 2 was 92.7% for both noncontrast and abbreviated sets. The sensitivity and specificity of two image sets were not significantly different for both reviewers. The per-tumor sensitivity of noncontrast and abbreviated sets was 81.5 and 84.4% for reviewer 1, respectively, and 79.8 and 84.4% for reviewer 2, respectively. There was no significant difference.
Conclusion
Noncontrast and abbreviated MRI using gadoxetic acid showed comparable diagnostic performance for detecting patients with HCCs in the early stage.
Key Points
• Diagnostic performance of noncontrast MRI and abbreviated MRI using gadoxetic acid for detecting HCCs is comparable in patients with HCCs in the early stage.
• Noncontrast MRI and abbreviated MRI showed high sensitivity and specificity for detecting HCCs in the early stage.
• Outcomes of surveillance for HCC in high-risk patients can be improved by adopting these simplified and focused MRI protocols. |
| doi_str_mv | 10.1007/s00330-020-06754-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2377339043</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2377339043</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-c59e348d5f2a8daec7cbbe76ab6826579fc803d6ed7e5344616cbfd3db904a743</originalsourceid><addsrcrecordid>eNp9kVGL1DAUhYso7uzqH_BBAr74Uk2TNGl9k0HXhRVB9DncJrdjljYZk3Rx_qs_xnRmV0FQSAjc8-XcA6eqnjX0VUOpep0o5ZzWlJUrVStq8aDaNIKzuqGdeFhtaM-7WvW9OKvOU7qhlPaNUI-rM84aKUXPN9XPbZj3EF0KnoSRWAc7H1J2huwxjiHO4A2uig--NsHnCCmTj5-vCHhLYBgi3jrIaI-zJTm_Izuw4QeuHmCcJc6X47KDaTrcLyj8N9xDDganaZkgEgPROB9mIGXs0Of0hgBJbi5qdiVdyos9rEnSEm_RTdMxWYn4T6f0pHo0wpTw6d17UX19_-7L9kN9_enyavv2ujZCNLk2bY9cdLYdGXQW0CgzDKgkDLJjslX9aDrKrUSrsOVCyEaaYbTcDj0VoAS_qF6efPcxfF8wZT27tOYBj2FJmnGlOC8wL-iLv9CbsERf0mkmWOlTMrZS7ESZGFKKOOp9dDPEg26oXrvXp-516V4fu9driud31sswo_395b7sAvATkIrkdxj_7P6P7S-lTcBq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2420336223</pqid></control><display><type>article</type><title>Comparison of diagnostic performance of non-contrast MRI and abbreviated MRI using gadoxetic acid in initially diagnosed hepatocellular carcinoma patients: a simulation study of surveillance for hepatocellular carcinomas</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Whang, Sunyoung ; Choi, Moon Hyung ; Choi, Joon-Il ; Youn, Seo Yeon ; Kim, Dong Hwan ; Rha, Sung Eun</creator><creatorcontrib>Whang, Sunyoung ; Choi, Moon Hyung ; Choi, Joon-Il ; Youn, Seo Yeon ; Kim, Dong Hwan ; Rha, Sung Eun</creatorcontrib><description>Objective
This study was conducted in order to compare the diagnostic performance of noncontrast and abbreviated MRI using gadoxetic acid for detecting hepatocellular carcinoma (HCC) in initially diagnosed HCC patients.
Methods
We identified 140 consecutive patients with newly diagnosed HCC (173 HCCs) within the Milan criteria, who underwent liver MRI using gadoxetic acid between 2015 and 2016. One hundred twenty-three consecutive patients without HCC who underwent liver MRI in the same period for HCC surveillance were enrolled for the control group. Two radiologists independently reviewed two MRI sets: a noncontrast set and an abbreviated set. The noncontrast set consists of T2 FSE/ssFSE, T1 in- and out-of-phase image, DWI, and the ADC map. The abbreviated set consists of T2 FSE/ssFSE, hepatobiliary phase image 20 min after gadoxetic acid injection, DWI, and the ADC map.
Results
In a per-patient analysis, sensitivity of reviewer 1 for noncontrast and abbreviated sets was 85.7 and 90.0%, respectively. The specificity for both noncontrast and abbreviated sets was 92.7%. For reviewer 2, sensitivity of noncontrast and abbreviated sets was 86.4 and 89.3%, respectively. Per-patient specificity of reviewer 2 was 92.7% for both noncontrast and abbreviated sets. The sensitivity and specificity of two image sets were not significantly different for both reviewers. The per-tumor sensitivity of noncontrast and abbreviated sets was 81.5 and 84.4% for reviewer 1, respectively, and 79.8 and 84.4% for reviewer 2, respectively. There was no significant difference.
Conclusion
Noncontrast and abbreviated MRI using gadoxetic acid showed comparable diagnostic performance for detecting patients with HCCs in the early stage.
Key Points
• Diagnostic performance of noncontrast MRI and abbreviated MRI using gadoxetic acid for detecting HCCs is comparable in patients with HCCs in the early stage.
• Noncontrast MRI and abbreviated MRI showed high sensitivity and specificity for detecting HCCs in the early stage.
• Outcomes of surveillance for HCC in high-risk patients can be improved by adopting these simplified and focused MRI protocols.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-020-06754-4</identifier><identifier>PMID: 32166493</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acids ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular - diagnostic imaging ; Contrast Media ; Diagnostic Radiology ; Diagnostic systems ; Diffusion Magnetic Resonance Imaging - methods ; Female ; Gadolinium DTPA ; Hepatobiliary-Pancreas ; Hepatocellular carcinoma ; Humans ; Identification methods ; Imaging ; Internal Medicine ; Interventional Radiology ; Liver ; Liver cancer ; Liver Neoplasms - diagnostic imaging ; Magnetic resonance imaging ; Male ; Medical diagnosis ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroradiology ; Patients ; Radiology ; Retrospective Studies ; Risk groups ; Sensitivity analysis ; Sensitivity and Specificity ; Surveillance ; Ultrasound ; Young Adult</subject><ispartof>European radiology, 2020-08, Vol.30 (8), p.4150-4163</ispartof><rights>European Society of Radiology 2020</rights><rights>European Society of Radiology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-c59e348d5f2a8daec7cbbe76ab6826579fc803d6ed7e5344616cbfd3db904a743</citedby><cites>FETCH-LOGICAL-c441t-c59e348d5f2a8daec7cbbe76ab6826579fc803d6ed7e5344616cbfd3db904a743</cites><orcidid>0000-0003-0018-8712</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-020-06754-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-020-06754-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32166493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whang, Sunyoung</creatorcontrib><creatorcontrib>Choi, Moon Hyung</creatorcontrib><creatorcontrib>Choi, Joon-Il</creatorcontrib><creatorcontrib>Youn, Seo Yeon</creatorcontrib><creatorcontrib>Kim, Dong Hwan</creatorcontrib><creatorcontrib>Rha, Sung Eun</creatorcontrib><title>Comparison of diagnostic performance of non-contrast MRI and abbreviated MRI using gadoxetic acid in initially diagnosed hepatocellular carcinoma patients: a simulation study of surveillance for hepatocellular carcinomas</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objective
This study was conducted in order to compare the diagnostic performance of noncontrast and abbreviated MRI using gadoxetic acid for detecting hepatocellular carcinoma (HCC) in initially diagnosed HCC patients.
Methods
We identified 140 consecutive patients with newly diagnosed HCC (173 HCCs) within the Milan criteria, who underwent liver MRI using gadoxetic acid between 2015 and 2016. One hundred twenty-three consecutive patients without HCC who underwent liver MRI in the same period for HCC surveillance were enrolled for the control group. Two radiologists independently reviewed two MRI sets: a noncontrast set and an abbreviated set. The noncontrast set consists of T2 FSE/ssFSE, T1 in- and out-of-phase image, DWI, and the ADC map. The abbreviated set consists of T2 FSE/ssFSE, hepatobiliary phase image 20 min after gadoxetic acid injection, DWI, and the ADC map.
Results
In a per-patient analysis, sensitivity of reviewer 1 for noncontrast and abbreviated sets was 85.7 and 90.0%, respectively. The specificity for both noncontrast and abbreviated sets was 92.7%. For reviewer 2, sensitivity of noncontrast and abbreviated sets was 86.4 and 89.3%, respectively. Per-patient specificity of reviewer 2 was 92.7% for both noncontrast and abbreviated sets. The sensitivity and specificity of two image sets were not significantly different for both reviewers. The per-tumor sensitivity of noncontrast and abbreviated sets was 81.5 and 84.4% for reviewer 1, respectively, and 79.8 and 84.4% for reviewer 2, respectively. There was no significant difference.
Conclusion
Noncontrast and abbreviated MRI using gadoxetic acid showed comparable diagnostic performance for detecting patients with HCCs in the early stage.
Key Points
• Diagnostic performance of noncontrast MRI and abbreviated MRI using gadoxetic acid for detecting HCCs is comparable in patients with HCCs in the early stage.
• Noncontrast MRI and abbreviated MRI showed high sensitivity and specificity for detecting HCCs in the early stage.
• Outcomes of surveillance for HCC in high-risk patients can be improved by adopting these simplified and focused MRI protocols.</description><subject>Acids</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Contrast Media</subject><subject>Diagnostic Radiology</subject><subject>Diagnostic systems</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Hepatobiliary-Pancreas</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Identification methods</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>Patients</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Risk groups</subject><subject>Sensitivity analysis</subject><subject>Sensitivity and Specificity</subject><subject>Surveillance</subject><subject>Ultrasound</subject><subject>Young Adult</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kVGL1DAUhYso7uzqH_BBAr74Uk2TNGl9k0HXhRVB9DncJrdjljYZk3Rx_qs_xnRmV0FQSAjc8-XcA6eqnjX0VUOpep0o5ZzWlJUrVStq8aDaNIKzuqGdeFhtaM-7WvW9OKvOU7qhlPaNUI-rM84aKUXPN9XPbZj3EF0KnoSRWAc7H1J2huwxjiHO4A2uig--NsHnCCmTj5-vCHhLYBgi3jrIaI-zJTm_Izuw4QeuHmCcJc6X47KDaTrcLyj8N9xDDganaZkgEgPROB9mIGXs0Of0hgBJbi5qdiVdyos9rEnSEm_RTdMxWYn4T6f0pHo0wpTw6d17UX19_-7L9kN9_enyavv2ujZCNLk2bY9cdLYdGXQW0CgzDKgkDLJjslX9aDrKrUSrsOVCyEaaYbTcDj0VoAS_qF6efPcxfF8wZT27tOYBj2FJmnGlOC8wL-iLv9CbsERf0mkmWOlTMrZS7ESZGFKKOOp9dDPEg26oXrvXp-516V4fu9driud31sswo_395b7sAvATkIrkdxj_7P6P7S-lTcBq</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Whang, Sunyoung</creator><creator>Choi, Moon Hyung</creator><creator>Choi, Joon-Il</creator><creator>Youn, Seo Yeon</creator><creator>Kim, Dong Hwan</creator><creator>Rha, Sung Eun</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0018-8712</orcidid></search><sort><creationdate>20200801</creationdate><title>Comparison of diagnostic performance of non-contrast MRI and abbreviated MRI using gadoxetic acid in initially diagnosed hepatocellular carcinoma patients: a simulation study of surveillance for hepatocellular carcinomas</title><author>Whang, Sunyoung ; Choi, Moon Hyung ; Choi, Joon-Il ; Youn, Seo Yeon ; Kim, Dong Hwan ; Rha, Sung Eun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-c59e348d5f2a8daec7cbbe76ab6826579fc803d6ed7e5344616cbfd3db904a743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Contrast Media</topic><topic>Diagnostic Radiology</topic><topic>Diagnostic systems</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Hepatobiliary-Pancreas</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Identification methods</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroradiology</topic><topic>Patients</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Risk groups</topic><topic>Sensitivity analysis</topic><topic>Sensitivity and Specificity</topic><topic>Surveillance</topic><topic>Ultrasound</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whang, Sunyoung</creatorcontrib><creatorcontrib>Choi, Moon Hyung</creatorcontrib><creatorcontrib>Choi, Joon-Il</creatorcontrib><creatorcontrib>Youn, Seo Yeon</creatorcontrib><creatorcontrib>Kim, Dong Hwan</creatorcontrib><creatorcontrib>Rha, Sung Eun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whang, Sunyoung</au><au>Choi, Moon Hyung</au><au>Choi, Joon-Il</au><au>Youn, Seo Yeon</au><au>Kim, Dong Hwan</au><au>Rha, Sung Eun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of diagnostic performance of non-contrast MRI and abbreviated MRI using gadoxetic acid in initially diagnosed hepatocellular carcinoma patients: a simulation study of surveillance for hepatocellular carcinomas</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>30</volume><issue>8</issue><spage>4150</spage><epage>4163</epage><pages>4150-4163</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objective
This study was conducted in order to compare the diagnostic performance of noncontrast and abbreviated MRI using gadoxetic acid for detecting hepatocellular carcinoma (HCC) in initially diagnosed HCC patients.
Methods
We identified 140 consecutive patients with newly diagnosed HCC (173 HCCs) within the Milan criteria, who underwent liver MRI using gadoxetic acid between 2015 and 2016. One hundred twenty-three consecutive patients without HCC who underwent liver MRI in the same period for HCC surveillance were enrolled for the control group. Two radiologists independently reviewed two MRI sets: a noncontrast set and an abbreviated set. The noncontrast set consists of T2 FSE/ssFSE, T1 in- and out-of-phase image, DWI, and the ADC map. The abbreviated set consists of T2 FSE/ssFSE, hepatobiliary phase image 20 min after gadoxetic acid injection, DWI, and the ADC map.
Results
In a per-patient analysis, sensitivity of reviewer 1 for noncontrast and abbreviated sets was 85.7 and 90.0%, respectively. The specificity for both noncontrast and abbreviated sets was 92.7%. For reviewer 2, sensitivity of noncontrast and abbreviated sets was 86.4 and 89.3%, respectively. Per-patient specificity of reviewer 2 was 92.7% for both noncontrast and abbreviated sets. The sensitivity and specificity of two image sets were not significantly different for both reviewers. The per-tumor sensitivity of noncontrast and abbreviated sets was 81.5 and 84.4% for reviewer 1, respectively, and 79.8 and 84.4% for reviewer 2, respectively. There was no significant difference.
Conclusion
Noncontrast and abbreviated MRI using gadoxetic acid showed comparable diagnostic performance for detecting patients with HCCs in the early stage.
Key Points
• Diagnostic performance of noncontrast MRI and abbreviated MRI using gadoxetic acid for detecting HCCs is comparable in patients with HCCs in the early stage.
• Noncontrast MRI and abbreviated MRI showed high sensitivity and specificity for detecting HCCs in the early stage.
• Outcomes of surveillance for HCC in high-risk patients can be improved by adopting these simplified and focused MRI protocols.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32166493</pmid><doi>10.1007/s00330-020-06754-4</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-0018-8712</orcidid></addata></record> |
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| ispartof | European radiology, 2020-08, Vol.30 (8), p.4150-4163 |
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| language | eng |
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| subjects | Acids Adult Aged Aged, 80 and over Carcinoma, Hepatocellular - diagnostic imaging Contrast Media Diagnostic Radiology Diagnostic systems Diffusion Magnetic Resonance Imaging - methods Female Gadolinium DTPA Hepatobiliary-Pancreas Hepatocellular carcinoma Humans Identification methods Imaging Internal Medicine Interventional Radiology Liver Liver cancer Liver Neoplasms - diagnostic imaging Magnetic resonance imaging Male Medical diagnosis Medical imaging Medicine Medicine & Public Health Middle Aged Neuroradiology Patients Radiology Retrospective Studies Risk groups Sensitivity analysis Sensitivity and Specificity Surveillance Ultrasound Young Adult |
| title | Comparison of diagnostic performance of non-contrast MRI and abbreviated MRI using gadoxetic acid in initially diagnosed hepatocellular carcinoma patients: a simulation study of surveillance for hepatocellular carcinomas |
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