The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata
A systematic review failed to identify any systemic therapy used in alopecia areata (AA) where use is supported by robust evidence from high-quality randomized controlled trials. To produce an international consensus statement on the use and utility of various treatments for AA. Fifty hair experts f...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 2020-07, Vol.83 (1), p.123-130 |
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| creator | Meah, Nekma Wall, Dmitri York, Katherine Bhoyrul, Bevin Bokhari, Laita Sigall, Daniel Asz Bergfeld, Wilma F. Betz, Regina C. Blume-Peytavi, Ulrike Callender, Valerie Chitreddy, Vijaya Combalia, Andrea Cotsarelis, George Craiglow, Brittany Donovan, Jeff Eisman, Samantha Farrant, Paul Green, Jack Grimalt, Ramon Harries, Matthew Hordinsky, Maria Irvine, Alan D. Itami, Satoshi Jolliffe, Victoria King, Brett Lee, Won-Soo McMichael, Amy Messenger, Andrew Mirmirani, Paradi Olsen, Elise Orlow, Seth J. Piraccini, Bianca Maria Rakowska, Adriana Reygagne, Pascal Roberts, Janet L. Rudnicka, Lidia Shapiro, Jerry Sharma, Pooja Tosti, Antonella Vogt, Annika Wade, Martin Yip, Leona Zlotogorski, Abraham Sinclair, Rodney |
| description | A systematic review failed to identify any systemic therapy used in alopecia areata (AA) where use is supported by robust evidence from high-quality randomized controlled trials.
To produce an international consensus statement on the use and utility of various treatments for AA.
Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Agreement of 66% or greater was considered consensus.
In the first round, consensus was achieved in 22 of 423 (5%) questions. After a face-to-face meeting in round 3, overall, consensus was achieved for only 130 (33%) treatment-specific questions. There was greater consensus for intralesional treatment of AA (19 [68%]) followed by topical treatment (25 [43%]). Consensus was achieved in 45 (36%) questions pertaining to systemic therapies in AA. The categories with the least consensus were phototherapy and nonprescription therapies.
The study included a comprehensive list of systemic treatments for AA but not all treatments used.
Despite divergent opinions among experts, consensus was achieved on a number of pertinent questions. The concluding statement also highlights areas where expert consensus is lacking and where an international patient registry could enable further research. |
| doi_str_mv | 10.1016/j.jaad.2020.03.004 |
| format | Article |
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To produce an international consensus statement on the use and utility of various treatments for AA.
Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Agreement of 66% or greater was considered consensus.
In the first round, consensus was achieved in 22 of 423 (5%) questions. After a face-to-face meeting in round 3, overall, consensus was achieved for only 130 (33%) treatment-specific questions. There was greater consensus for intralesional treatment of AA (19 [68%]) followed by topical treatment (25 [43%]). Consensus was achieved in 45 (36%) questions pertaining to systemic therapies in AA. The categories with the least consensus were phototherapy and nonprescription therapies.
The study included a comprehensive list of systemic treatments for AA but not all treatments used.
Despite divergent opinions among experts, consensus was achieved on a number of pertinent questions. The concluding statement also highlights areas where expert consensus is lacking and where an international patient registry could enable further research.</description><identifier>ISSN: 0190-9622</identifier><identifier>ISSN: 1097-6787</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2020.03.004</identifier><identifier>PMID: 32165196</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Administration, Oral ; Administration, Topical ; Adrenal Cortex Hormones - therapeutic use ; Age Factors ; Alopecia Areata - drug therapy ; Alopecia Areata - therapy ; Combined Modality Therapy ; Complementary Therapies ; Delphi Technique ; Dermatologic Agents - therapeutic use ; Humans ; Injections, Intralesional ; Phototherapy ; Severity of Illness Index ; Treatment Outcome</subject><ispartof>Journal of the American Academy of Dermatology, 2020-07, Vol.83 (1), p.123-130</ispartof><rights>2020 American Academy of Dermatology, Inc.</rights><rights>Copyright © 2020 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-36b19f90f3109469d2737ea03c7025a70051b2fd273de5c8607cdb4d9efcbd813</citedby><cites>FETCH-LOGICAL-c356t-36b19f90f3109469d2737ea03c7025a70051b2fd273de5c8607cdb4d9efcbd813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0190962220303753$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32165196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meah, Nekma</creatorcontrib><creatorcontrib>Wall, Dmitri</creatorcontrib><creatorcontrib>York, Katherine</creatorcontrib><creatorcontrib>Bhoyrul, Bevin</creatorcontrib><creatorcontrib>Bokhari, Laita</creatorcontrib><creatorcontrib>Sigall, Daniel Asz</creatorcontrib><creatorcontrib>Bergfeld, Wilma F.</creatorcontrib><creatorcontrib>Betz, Regina C.</creatorcontrib><creatorcontrib>Blume-Peytavi, Ulrike</creatorcontrib><creatorcontrib>Callender, Valerie</creatorcontrib><creatorcontrib>Chitreddy, Vijaya</creatorcontrib><creatorcontrib>Combalia, Andrea</creatorcontrib><creatorcontrib>Cotsarelis, George</creatorcontrib><creatorcontrib>Craiglow, Brittany</creatorcontrib><creatorcontrib>Donovan, Jeff</creatorcontrib><creatorcontrib>Eisman, Samantha</creatorcontrib><creatorcontrib>Farrant, Paul</creatorcontrib><creatorcontrib>Green, Jack</creatorcontrib><creatorcontrib>Grimalt, Ramon</creatorcontrib><creatorcontrib>Harries, Matthew</creatorcontrib><creatorcontrib>Hordinsky, Maria</creatorcontrib><creatorcontrib>Irvine, Alan D.</creatorcontrib><creatorcontrib>Itami, Satoshi</creatorcontrib><creatorcontrib>Jolliffe, Victoria</creatorcontrib><creatorcontrib>King, Brett</creatorcontrib><creatorcontrib>Lee, Won-Soo</creatorcontrib><creatorcontrib>McMichael, Amy</creatorcontrib><creatorcontrib>Messenger, Andrew</creatorcontrib><creatorcontrib>Mirmirani, Paradi</creatorcontrib><creatorcontrib>Olsen, Elise</creatorcontrib><creatorcontrib>Orlow, Seth J.</creatorcontrib><creatorcontrib>Piraccini, Bianca Maria</creatorcontrib><creatorcontrib>Rakowska, Adriana</creatorcontrib><creatorcontrib>Reygagne, Pascal</creatorcontrib><creatorcontrib>Roberts, Janet L.</creatorcontrib><creatorcontrib>Rudnicka, Lidia</creatorcontrib><creatorcontrib>Shapiro, Jerry</creatorcontrib><creatorcontrib>Sharma, Pooja</creatorcontrib><creatorcontrib>Tosti, Antonella</creatorcontrib><creatorcontrib>Vogt, Annika</creatorcontrib><creatorcontrib>Wade, Martin</creatorcontrib><creatorcontrib>Yip, Leona</creatorcontrib><creatorcontrib>Zlotogorski, Abraham</creatorcontrib><creatorcontrib>Sinclair, Rodney</creatorcontrib><title>The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>A systematic review failed to identify any systemic therapy used in alopecia areata (AA) where use is supported by robust evidence from high-quality randomized controlled trials.
To produce an international consensus statement on the use and utility of various treatments for AA.
Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Agreement of 66% or greater was considered consensus.
In the first round, consensus was achieved in 22 of 423 (5%) questions. After a face-to-face meeting in round 3, overall, consensus was achieved for only 130 (33%) treatment-specific questions. There was greater consensus for intralesional treatment of AA (19 [68%]) followed by topical treatment (25 [43%]). Consensus was achieved in 45 (36%) questions pertaining to systemic therapies in AA. The categories with the least consensus were phototherapy and nonprescription therapies.
The study included a comprehensive list of systemic treatments for AA but not all treatments used.
Despite divergent opinions among experts, consensus was achieved on a number of pertinent questions. The concluding statement also highlights areas where expert consensus is lacking and where an international patient registry could enable further research.</description><subject>Administration, Oral</subject><subject>Administration, Topical</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Age Factors</subject><subject>Alopecia Areata - drug therapy</subject><subject>Alopecia Areata - therapy</subject><subject>Combined Modality Therapy</subject><subject>Complementary Therapies</subject><subject>Delphi Technique</subject><subject>Dermatologic Agents - therapeutic use</subject><subject>Humans</subject><subject>Injections, Intralesional</subject><subject>Phototherapy</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><issn>0190-9622</issn><issn>1097-6787</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEGLFDEQhYMo7rj6BzxIjuuh20oynUyLl2EYdWFhYVnPIZ1UY4aepE3S4l795XbP7HpcKCioeu8V9RHynkHNgMlPh_pgjKs5cKhB1ADrF2TFoFWVVBv1kqyAtVC1kvML8ibnAwC0a6FekwvBmWxYK1fk7_1PpNshjmi9oduEphi6iyFjyFOmsaf7PyOmkunVdrf_SHOZ3MNneod5GsppbwL1oWAKpvgYzEDxZKBx9GEe0LnKEnvEMBv6mKh5OmdO596SV70ZMr577Jfkx9f9_e57dXP77Xq3vamsaGSphOxY27fQi_nFtWwdV0KhAWEV8MYogIZ1vF_GDhu7kaCs69auxd52bsPEJbk6544p_powF3302eIwmIBxypoLpYTYcN7MUn6W2hRzTtjrMfmjSQ-agV7Y64Ne2OuFvQahZ_az6cNj_tQd0f23PMGeBV_OApy__O0x6Ww9BovOJ7RFu-ify_8Hw2WV7A</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Meah, Nekma</creator><creator>Wall, Dmitri</creator><creator>York, Katherine</creator><creator>Bhoyrul, Bevin</creator><creator>Bokhari, Laita</creator><creator>Sigall, Daniel Asz</creator><creator>Bergfeld, Wilma F.</creator><creator>Betz, Regina C.</creator><creator>Blume-Peytavi, Ulrike</creator><creator>Callender, Valerie</creator><creator>Chitreddy, Vijaya</creator><creator>Combalia, Andrea</creator><creator>Cotsarelis, George</creator><creator>Craiglow, Brittany</creator><creator>Donovan, Jeff</creator><creator>Eisman, Samantha</creator><creator>Farrant, Paul</creator><creator>Green, Jack</creator><creator>Grimalt, Ramon</creator><creator>Harries, Matthew</creator><creator>Hordinsky, Maria</creator><creator>Irvine, Alan D.</creator><creator>Itami, Satoshi</creator><creator>Jolliffe, Victoria</creator><creator>King, Brett</creator><creator>Lee, Won-Soo</creator><creator>McMichael, Amy</creator><creator>Messenger, Andrew</creator><creator>Mirmirani, Paradi</creator><creator>Olsen, Elise</creator><creator>Orlow, Seth J.</creator><creator>Piraccini, Bianca Maria</creator><creator>Rakowska, Adriana</creator><creator>Reygagne, Pascal</creator><creator>Roberts, Janet L.</creator><creator>Rudnicka, Lidia</creator><creator>Shapiro, Jerry</creator><creator>Sharma, Pooja</creator><creator>Tosti, Antonella</creator><creator>Vogt, Annika</creator><creator>Wade, Martin</creator><creator>Yip, Leona</creator><creator>Zlotogorski, Abraham</creator><creator>Sinclair, Rodney</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202007</creationdate><title>The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata</title><author>Meah, Nekma ; Wall, Dmitri ; York, Katherine ; Bhoyrul, Bevin ; Bokhari, Laita ; Sigall, Daniel Asz ; Bergfeld, Wilma F. ; Betz, Regina C. ; Blume-Peytavi, Ulrike ; Callender, Valerie ; Chitreddy, Vijaya ; Combalia, Andrea ; Cotsarelis, George ; Craiglow, Brittany ; Donovan, Jeff ; Eisman, Samantha ; Farrant, Paul ; Green, Jack ; Grimalt, Ramon ; Harries, Matthew ; Hordinsky, Maria ; Irvine, Alan D. ; Itami, Satoshi ; Jolliffe, Victoria ; King, Brett ; Lee, Won-Soo ; McMichael, Amy ; Messenger, Andrew ; Mirmirani, Paradi ; Olsen, Elise ; Orlow, Seth J. ; Piraccini, Bianca Maria ; Rakowska, Adriana ; Reygagne, Pascal ; Roberts, Janet L. ; Rudnicka, Lidia ; Shapiro, Jerry ; Sharma, Pooja ; Tosti, Antonella ; Vogt, Annika ; Wade, Martin ; Yip, Leona ; Zlotogorski, Abraham ; Sinclair, Rodney</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-36b19f90f3109469d2737ea03c7025a70051b2fd273de5c8607cdb4d9efcbd813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Administration, Oral</topic><topic>Administration, Topical</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Age Factors</topic><topic>Alopecia Areata - drug therapy</topic><topic>Alopecia Areata - therapy</topic><topic>Combined Modality Therapy</topic><topic>Complementary Therapies</topic><topic>Delphi Technique</topic><topic>Dermatologic Agents - therapeutic use</topic><topic>Humans</topic><topic>Injections, Intralesional</topic><topic>Phototherapy</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meah, Nekma</creatorcontrib><creatorcontrib>Wall, Dmitri</creatorcontrib><creatorcontrib>York, Katherine</creatorcontrib><creatorcontrib>Bhoyrul, Bevin</creatorcontrib><creatorcontrib>Bokhari, Laita</creatorcontrib><creatorcontrib>Sigall, Daniel Asz</creatorcontrib><creatorcontrib>Bergfeld, Wilma F.</creatorcontrib><creatorcontrib>Betz, Regina C.</creatorcontrib><creatorcontrib>Blume-Peytavi, Ulrike</creatorcontrib><creatorcontrib>Callender, Valerie</creatorcontrib><creatorcontrib>Chitreddy, Vijaya</creatorcontrib><creatorcontrib>Combalia, Andrea</creatorcontrib><creatorcontrib>Cotsarelis, George</creatorcontrib><creatorcontrib>Craiglow, Brittany</creatorcontrib><creatorcontrib>Donovan, Jeff</creatorcontrib><creatorcontrib>Eisman, Samantha</creatorcontrib><creatorcontrib>Farrant, Paul</creatorcontrib><creatorcontrib>Green, Jack</creatorcontrib><creatorcontrib>Grimalt, Ramon</creatorcontrib><creatorcontrib>Harries, Matthew</creatorcontrib><creatorcontrib>Hordinsky, Maria</creatorcontrib><creatorcontrib>Irvine, Alan D.</creatorcontrib><creatorcontrib>Itami, Satoshi</creatorcontrib><creatorcontrib>Jolliffe, Victoria</creatorcontrib><creatorcontrib>King, Brett</creatorcontrib><creatorcontrib>Lee, Won-Soo</creatorcontrib><creatorcontrib>McMichael, Amy</creatorcontrib><creatorcontrib>Messenger, Andrew</creatorcontrib><creatorcontrib>Mirmirani, Paradi</creatorcontrib><creatorcontrib>Olsen, Elise</creatorcontrib><creatorcontrib>Orlow, Seth J.</creatorcontrib><creatorcontrib>Piraccini, Bianca Maria</creatorcontrib><creatorcontrib>Rakowska, Adriana</creatorcontrib><creatorcontrib>Reygagne, Pascal</creatorcontrib><creatorcontrib>Roberts, Janet L.</creatorcontrib><creatorcontrib>Rudnicka, Lidia</creatorcontrib><creatorcontrib>Shapiro, Jerry</creatorcontrib><creatorcontrib>Sharma, Pooja</creatorcontrib><creatorcontrib>Tosti, Antonella</creatorcontrib><creatorcontrib>Vogt, Annika</creatorcontrib><creatorcontrib>Wade, Martin</creatorcontrib><creatorcontrib>Yip, Leona</creatorcontrib><creatorcontrib>Zlotogorski, Abraham</creatorcontrib><creatorcontrib>Sinclair, Rodney</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meah, Nekma</au><au>Wall, Dmitri</au><au>York, Katherine</au><au>Bhoyrul, Bevin</au><au>Bokhari, Laita</au><au>Sigall, Daniel Asz</au><au>Bergfeld, Wilma F.</au><au>Betz, Regina C.</au><au>Blume-Peytavi, Ulrike</au><au>Callender, Valerie</au><au>Chitreddy, Vijaya</au><au>Combalia, Andrea</au><au>Cotsarelis, George</au><au>Craiglow, Brittany</au><au>Donovan, Jeff</au><au>Eisman, Samantha</au><au>Farrant, Paul</au><au>Green, Jack</au><au>Grimalt, Ramon</au><au>Harries, Matthew</au><au>Hordinsky, Maria</au><au>Irvine, Alan D.</au><au>Itami, Satoshi</au><au>Jolliffe, Victoria</au><au>King, Brett</au><au>Lee, Won-Soo</au><au>McMichael, Amy</au><au>Messenger, Andrew</au><au>Mirmirani, Paradi</au><au>Olsen, Elise</au><au>Orlow, Seth J.</au><au>Piraccini, Bianca Maria</au><au>Rakowska, Adriana</au><au>Reygagne, Pascal</au><au>Roberts, Janet L.</au><au>Rudnicka, Lidia</au><au>Shapiro, Jerry</au><au>Sharma, Pooja</au><au>Tosti, Antonella</au><au>Vogt, Annika</au><au>Wade, Martin</au><au>Yip, Leona</au><au>Zlotogorski, Abraham</au><au>Sinclair, Rodney</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2020-07</date><risdate>2020</risdate><volume>83</volume><issue>1</issue><spage>123</spage><epage>130</epage><pages>123-130</pages><issn>0190-9622</issn><issn>1097-6787</issn><eissn>1097-6787</eissn><abstract>A systematic review failed to identify any systemic therapy used in alopecia areata (AA) where use is supported by robust evidence from high-quality randomized controlled trials.
To produce an international consensus statement on the use and utility of various treatments for AA.
Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Agreement of 66% or greater was considered consensus.
In the first round, consensus was achieved in 22 of 423 (5%) questions. After a face-to-face meeting in round 3, overall, consensus was achieved for only 130 (33%) treatment-specific questions. There was greater consensus for intralesional treatment of AA (19 [68%]) followed by topical treatment (25 [43%]). Consensus was achieved in 45 (36%) questions pertaining to systemic therapies in AA. The categories with the least consensus were phototherapy and nonprescription therapies.
The study included a comprehensive list of systemic treatments for AA but not all treatments used.
Despite divergent opinions among experts, consensus was achieved on a number of pertinent questions. The concluding statement also highlights areas where expert consensus is lacking and where an international patient registry could enable further research.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32165196</pmid><doi>10.1016/j.jaad.2020.03.004</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0190-9622 |
| ispartof | Journal of the American Academy of Dermatology, 2020-07, Vol.83 (1), p.123-130 |
| issn | 0190-9622 1097-6787 1097-6787 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2377338225 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Oral Administration, Topical Adrenal Cortex Hormones - therapeutic use Age Factors Alopecia Areata - drug therapy Alopecia Areata - therapy Combined Modality Therapy Complementary Therapies Delphi Technique Dermatologic Agents - therapeutic use Humans Injections, Intralesional Phototherapy Severity of Illness Index Treatment Outcome |
| title | The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T19%3A53%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Alopecia%20Areata%20Consensus%20of%20Experts%20(ACE)%20study:%20Results%20of%20an%20international%20expert%20opinion%20on%20treatments%20for%20alopecia%20areata&rft.jtitle=Journal%20of%20the%20American%20Academy%20of%20Dermatology&rft.au=Meah,%20Nekma&rft.date=2020-07&rft.volume=83&rft.issue=1&rft.spage=123&rft.epage=130&rft.pages=123-130&rft.issn=0190-9622&rft.eissn=1097-6787&rft_id=info:doi/10.1016/j.jaad.2020.03.004&rft_dat=%3Cproquest_cross%3E2377338225%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2377338225&rft_id=info:pmid/32165196&rft_els_id=S0190962220303753&rfr_iscdi=true |