$Matrix effects of the hydroethanolic extract and the butanol fraction of calyces from Physalis peruviana L. on the biopharmaceutics classification of rutin$

Matrix effects of the hydroethanolic extract and the butanol fraction of calyces from Physalis peruviana L. on the biopharmaceutics classification of rutin

Abstract Objectives The Biopharmaceutics Classification System (BCS) categorizes active pharmaceutical ingredients according to their solubility and permeability properties, which are susceptible to matrix or formulation effects. The aim of this research was to evaluate the matrix effects of a hydro...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2020-05, Vol.72 (5), p.738-747
Hauptverfasser:	Domínguez Moré, Gina Paola, Feltrin, Clarissa, Brambila, Paula Freire, Cardona, María Isabel, Echeverry, Sandra Milena, Simões, Cláudia Maria Oliveira, Aragón, Diana Marcela
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioequivalence Biopharmaceuticals Biopharmaceutics - classification Biopharmaceutics Classification System Butanol Butanols - chemistry Caco-2 Cells Chromatography, High Pressure Liquid Drug development Ethanol - chemistry Flowers - chemistry Flowers - metabolism Glucosides - chemistry Glucosides - classification Glucosides - metabolism High-performance liquid chromatography Humans Intestines - physiology Liquid-Liquid Extraction Membrane permeability Permeability Physalis - chemistry Physalis peruviana Plant Extracts - chemistry Plant Extracts - metabolism Quercetin Quercetin - analogs & derivatives Quercetin - chemistry Quercetin - classification Quercetin - metabolism R&D Research & development Rutin Rutin - chemistry Rutin - classification Rutin - metabolism Solubility
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