Body mass index moderates the association between gait kinetics, body composition, and femoral knee cartilage characteristics
This study compared femoral cartilage characteristics between age‐ and sex‐matched individuals with (n = 48, age = 22.8 ± 3.5 years; body mass index [BMI] = 33.1 ± 4.1 kg/m2) and without obesity (n = 48 age = 22.0 ± 2.6 years; BMI = 21.7 ± 1.7 kg/m2) and evaluated the associations between body compo...
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| Veröffentlicht in: | Journal of orthopaedic research 2020-12, Vol.38 (12), p.2685-2695 |
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| creator | Pamukoff, Derek N. Vakula, Michael N. Holmes, Skylar C. Shumski, Eric J. Garcia, Steven A. |
| description | This study compared femoral cartilage characteristics between age‐ and sex‐matched individuals with (n = 48, age = 22.8 ± 3.5 years; body mass index [BMI] = 33.1 ± 4.1 kg/m2) and without obesity (n = 48 age = 22.0 ± 2.6 years; BMI = 21.7 ± 1.7 kg/m2) and evaluated the associations between body composition, quadriceps function, and gait kinetics with femoral cartilage characteristics. Medial and lateral femoral cartilage thickness, medial:lateral thickness ratio and medial and lateral cartilage echo intensity were measured using ultrasound imaging. Body composition was assessed using air displacement plethysmography. Quadriceps function was assessed via maximal isometric knee extension. Three‐dimensional gait biomechanics were recorded to extract peak external knee flexion and adduction moments, and peak loading rate of the vertical ground reaction force. Cartilage outcomes were compared between groups using one‐way multivariate analysis of variance. Stepwise moderated regression evaluated the association between body composition, quadriceps function, and gait kinetics with femoral cartilage outcomes in individuals with and without obesity. Medial (75.24 vs 65.84; P |
| doi_str_mv | 10.1002/jor.24655 |
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Medial and lateral femoral cartilage thickness, medial:lateral thickness ratio and medial and lateral cartilage echo intensity were measured using ultrasound imaging. Body composition was assessed using air displacement plethysmography. Quadriceps function was assessed via maximal isometric knee extension. Three‐dimensional gait biomechanics were recorded to extract peak external knee flexion and adduction moments, and peak loading rate of the vertical ground reaction force. Cartilage outcomes were compared between groups using one‐way multivariate analysis of variance. Stepwise moderated regression evaluated the association between body composition, quadriceps function, and gait kinetics with femoral cartilage outcomes in individuals with and without obesity. Medial (75.24 vs 65.84; P < .001, d = 1.02) and lateral (58.81 vs 52.22; P < .001, d = 0.78) femoral cartilage echo intensity were higher in individuals with compared with those without obesity. A higher body fat percentage was associated with higher medial and lateral cartilage echo intensity (ΔR2 = 0.09‐0.12) in individuals with obesity. A higher knee adduction moment was associated with a larger medial:lateral thickness ratio (ΔR2 = 0.09) in individuals without obesity. No associations were found between quadriceps function and cartilage outcomes. These findings suggest that high body fat in adults with obesity is associated with cartilage echo intensity. The obese body mass index was also associated with a lack of a positive relationship between cartilage thickness and joint loading during walking.</description><identifier>ISSN: 0736-0266</identifier><identifier>EISSN: 1554-527X</identifier><identifier>DOI: 10.1002/jor.24655</identifier><identifier>PMID: 32162713</identifier><language>eng</language><publisher>United States</publisher><subject>biomechanics ; Body Mass Index ; Cartilage, Articular - diagnostic imaging ; Cartilage, Articular - pathology ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Femur - diagnostic imaging ; Femur - pathology ; Gait ; Humans ; knee ; Male ; obesity ; Obesity - complications ; Obesity - pathology ; Obesity - physiopathology ; osteoarthritis ; Osteoarthritis, Knee - etiology ; Osteoarthritis, Knee - physiopathology ; Quadriceps Muscle - physiology ; Ultrasonography ; ultrasound ; walking ; Young Adult</subject><ispartof>Journal of orthopaedic research, 2020-12, Vol.38 (12), p.2685-2695</ispartof><rights>2020 Orthopaedic Research Society. 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Medial and lateral femoral cartilage thickness, medial:lateral thickness ratio and medial and lateral cartilage echo intensity were measured using ultrasound imaging. Body composition was assessed using air displacement plethysmography. Quadriceps function was assessed via maximal isometric knee extension. Three‐dimensional gait biomechanics were recorded to extract peak external knee flexion and adduction moments, and peak loading rate of the vertical ground reaction force. Cartilage outcomes were compared between groups using one‐way multivariate analysis of variance. Stepwise moderated regression evaluated the association between body composition, quadriceps function, and gait kinetics with femoral cartilage outcomes in individuals with and without obesity. Medial (75.24 vs 65.84; P < .001, d = 1.02) and lateral (58.81 vs 52.22; P < .001, d = 0.78) femoral cartilage echo intensity were higher in individuals with compared with those without obesity. A higher body fat percentage was associated with higher medial and lateral cartilage echo intensity (ΔR2 = 0.09‐0.12) in individuals with obesity. A higher knee adduction moment was associated with a larger medial:lateral thickness ratio (ΔR2 = 0.09) in individuals without obesity. No associations were found between quadriceps function and cartilage outcomes. These findings suggest that high body fat in adults with obesity is associated with cartilage echo intensity. The obese body mass index was also associated with a lack of a positive relationship between cartilage thickness and joint loading during walking.</description><subject>biomechanics</subject><subject>Body Mass Index</subject><subject>Cartilage, Articular - diagnostic imaging</subject><subject>Cartilage, Articular - pathology</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Femur - diagnostic imaging</subject><subject>Femur - pathology</subject><subject>Gait</subject><subject>Humans</subject><subject>knee</subject><subject>Male</subject><subject>obesity</subject><subject>Obesity - complications</subject><subject>Obesity - pathology</subject><subject>Obesity - physiopathology</subject><subject>osteoarthritis</subject><subject>Osteoarthritis, Knee - etiology</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Quadriceps Muscle - physiology</subject><subject>Ultrasonography</subject><subject>ultrasound</subject><subject>walking</subject><subject>Young Adult</subject><issn>0736-0266</issn><issn>1554-527X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOwzAUQC0EglIY-AHkEaSG-hEnzQiIpypVQh3YItu5bl2SuNiuoAP_TkoLG5OvrHOPrg5CZ5RcUULYcOH8FUszIfZQjwqRJoLlr_uoR3KeJYRl2RE6DmFBCMkpGx2iI85oxnLKe-jrxlVr3MgQsG0r-MSNq8DLCAHHOeDu32kro3UtVhA_AFo8kzbiN9tCtDoMsNoItGuWLtgNN8CyrbCBxnlZ47cWAGvpo63lrJvm0ksdwduw2T5BB0bWAU53bx9N7--mt4_JePLwdHs9TjTPiEgEpUobXaUqVd3hio5yQknGgSjDjVamKjRXI6UKUwjNOHBiTGVGhShSLRjvo4utdund-wpCLBsbNNS1bMGtQsl4nuWcpIR36OUW1d6F4MGUS28b6dclJeUmdtnFLn9id-z5TrtSDVR_5G_dDhhugQ9bw_p_U_k8edkqvwFcUov7</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Pamukoff, Derek N.</creator><creator>Vakula, Michael N.</creator><creator>Holmes, Skylar C.</creator><creator>Shumski, Eric J.</creator><creator>Garcia, Steven A.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6266-0184</orcidid><orcidid>https://orcid.org/0000-0001-7636-3164</orcidid></search><sort><creationdate>202012</creationdate><title>Body mass index moderates the association between gait kinetics, body composition, and femoral knee cartilage characteristics</title><author>Pamukoff, Derek N. ; Vakula, Michael N. ; Holmes, Skylar C. ; Shumski, Eric J. ; Garcia, Steven A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3605-511bcfcd4b4b162b18701063e0bf3fcbfd9c3b8bb9f95c23e30ffdf89594c523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>biomechanics</topic><topic>Body Mass Index</topic><topic>Cartilage, Articular - diagnostic imaging</topic><topic>Cartilage, Articular - pathology</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Femur - diagnostic imaging</topic><topic>Femur - pathology</topic><topic>Gait</topic><topic>Humans</topic><topic>knee</topic><topic>Male</topic><topic>obesity</topic><topic>Obesity - complications</topic><topic>Obesity - pathology</topic><topic>Obesity - physiopathology</topic><topic>osteoarthritis</topic><topic>Osteoarthritis, Knee - etiology</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>Quadriceps Muscle - physiology</topic><topic>Ultrasonography</topic><topic>ultrasound</topic><topic>walking</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pamukoff, Derek N.</creatorcontrib><creatorcontrib>Vakula, Michael N.</creatorcontrib><creatorcontrib>Holmes, Skylar C.</creatorcontrib><creatorcontrib>Shumski, Eric J.</creatorcontrib><creatorcontrib>Garcia, Steven A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of orthopaedic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pamukoff, Derek N.</au><au>Vakula, Michael N.</au><au>Holmes, Skylar C.</au><au>Shumski, Eric J.</au><au>Garcia, Steven A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body mass index moderates the association between gait kinetics, body composition, and femoral knee cartilage characteristics</atitle><jtitle>Journal of orthopaedic research</jtitle><addtitle>J Orthop Res</addtitle><date>2020-12</date><risdate>2020</risdate><volume>38</volume><issue>12</issue><spage>2685</spage><epage>2695</epage><pages>2685-2695</pages><issn>0736-0266</issn><eissn>1554-527X</eissn><abstract>This study compared femoral cartilage characteristics between age‐ and sex‐matched individuals with (n = 48, age = 22.8 ± 3.5 years; body mass index [BMI] = 33.1 ± 4.1 kg/m2) and without obesity (n = 48 age = 22.0 ± 2.6 years; BMI = 21.7 ± 1.7 kg/m2) and evaluated the associations between body composition, quadriceps function, and gait kinetics with femoral cartilage characteristics. Medial and lateral femoral cartilage thickness, medial:lateral thickness ratio and medial and lateral cartilage echo intensity were measured using ultrasound imaging. Body composition was assessed using air displacement plethysmography. Quadriceps function was assessed via maximal isometric knee extension. Three‐dimensional gait biomechanics were recorded to extract peak external knee flexion and adduction moments, and peak loading rate of the vertical ground reaction force. Cartilage outcomes were compared between groups using one‐way multivariate analysis of variance. Stepwise moderated regression evaluated the association between body composition, quadriceps function, and gait kinetics with femoral cartilage outcomes in individuals with and without obesity. Medial (75.24 vs 65.84; P < .001, d = 1.02) and lateral (58.81 vs 52.22; P < .001, d = 0.78) femoral cartilage echo intensity were higher in individuals with compared with those without obesity. A higher body fat percentage was associated with higher medial and lateral cartilage echo intensity (ΔR2 = 0.09‐0.12) in individuals with obesity. A higher knee adduction moment was associated with a larger medial:lateral thickness ratio (ΔR2 = 0.09) in individuals without obesity. No associations were found between quadriceps function and cartilage outcomes. These findings suggest that high body fat in adults with obesity is associated with cartilage echo intensity. The obese body mass index was also associated with a lack of a positive relationship between cartilage thickness and joint loading during walking.</abstract><cop>United States</cop><pmid>32162713</pmid><doi>10.1002/jor.24655</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6266-0184</orcidid><orcidid>https://orcid.org/0000-0001-7636-3164</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | biomechanics Body Mass Index Cartilage, Articular - diagnostic imaging Cartilage, Articular - pathology Case-Control Studies Cross-Sectional Studies Female Femur - diagnostic imaging Femur - pathology Gait Humans knee Male obesity Obesity - complications Obesity - pathology Obesity - physiopathology osteoarthritis Osteoarthritis, Knee - etiology Osteoarthritis, Knee - physiopathology Quadriceps Muscle - physiology Ultrasonography ultrasound walking Young Adult |
| title | Body mass index moderates the association between gait kinetics, body composition, and femoral knee cartilage characteristics |
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