CD8-Specific Designed Ankyrin Repeat Proteins Improve Selective Gene Delivery into Human and Primate T Lymphocytes

Adoptive T cell immunotherapy in combination with gene therapy is a promising treatment concept for chronic infections and cancer. Recently, receptor-targeted lentiviral vectors (LVs) were shown to enable selective gene transfer into particular types of lymphocytes both and . This approach might fac...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human gene therapy 2020-06, Vol.31 (11-12), p.679-691
Hauptverfasser:	Frank, Annika M, Weidner, Tatjana, Brynza, Julia, Uckert, Wolfgang, Buchholz, Christian J, Hartmann, Jessica
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Ankyrins Binders CD8 antigen Cytotoxicity Design modifications Expression vectors Gene therapy Gene transfer Genetic engineering Immunotherapy Lymphocytes Lymphocytes T Precision medicine Proteins Receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!