A Comparative Study on the Clinical Features of Coronavirus 2019 (COVID-19) Pneumonia With Other Pneumonias
Abstract Background A novel coronavirus (COVID-19) has raised world concern since it emerged in Wuhan, China in December 2019. The infection may result in severe pneumonia with clusters of illness onsets. Its impacts on public health make it paramount to clarify the clinical features with other pneu...
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| Veröffentlicht in: | Clinical infectious diseases 2020-07, Vol.71 (15), p.756-761 |
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| creator | Zhao, Dahai Yao, Feifei Wang, Lijie Zheng, Ling Gao, Yongjun Ye, Jun Guo, Feng Zhao, Hui Gao, Rongbao |
| description | Abstract
Background
A novel coronavirus (COVID-19) has raised world concern since it emerged in Wuhan, China in December 2019. The infection may result in severe pneumonia with clusters of illness onsets. Its impacts on public health make it paramount to clarify the clinical features with other pneumonias.
Methods
Nineteen COVID-19 and 15 other patients with pneumonia (non-COVID-19) in areas outside of Hubei were involved in this study. Both COVID-19 and non-COVID-19 patients were confirmed to be infected using throat swabs and/or sputa with/without COVID-2019 by real-time RT-PCR. We analyzed the demographic, epidemiological, clinical, and radiological features from those patients, and compared the differences between COVID-19 and non-COVID-19.
Results
All patients had a history of exposure to confirmed cases of COVID-19 or travel to Hubei before illness. The median (IQR) duration was 8 (6–11) and 5 (4–11) days from exposure to onset in COVID-19 and non-COVID-19 cases, respectively. The clinical symptoms were similar between COVID-19 and non-COVID-19. The most common symptoms were fever and cough. Fifteen (78.95%) COVID-19 but 4 (26.67%) non-COVID-19 patients had bilateral involvement while 17 COVID-19 patients (89.47%) but 1 non-COVID-19 patient (6.67%) had multiple mottling and ground-glass opacity on chest CT images. Compared with non-COVID-19, COVID-19 presents remarkably more abnormal laboratory tests, including AST, ALT, γ-GT, LDH, and α-HBDH.
Conclusions
The COVID-19 infection has onsets similar to other pneumonias. CT scan may be a reliable test for screening COVID-19 cases. Liver function damage is more frequent in COVID-19 than non-COVID-19 patients. LDH and α-HBDH may be considerable markers for evaluation of COVID-19.
COVID-19 infection caused similar onsets to other pneumonias. Chest tomography scan may be a reliable test for screening COVID-19 cases. Liver function damage is more frequent in COVID-19 than non-COVID-19. Lactate dehydrogenase and α-hydroxybutyric dehydrogenase may be considerable markers for evaluation of COVID-19. |
| doi_str_mv | 10.1093/cid/ciaa247 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2376727640</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/cid/ciaa247</oup_id><sourcerecordid>2376727640</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-cd88a50f83b9f899ca6f147aae23368a17e47a0f8a761cc94e07fed44349ecc13</originalsourceid><addsrcrecordid>eNp9kM1LwzAYh4MoTqcn75KTTKSaNG2THEd1OhhM8OtY3qUpi7bNTNrB_nsjm3rz8PJ-PTyHH0JnlFxTItmNMmUogDjhe-iIpoxHWSrpfphJKqJEMDFAx96_E0KpIOkhGrCYZlRm4gh9jHFumxU46Mxa46euLzfYtrhbapzXpjUKajzR0PVOe2yrQDvbwtq43uOYUIlH-fx1ehtReYkfW903tjWA30y3xPMgcX9Hf4IOKqi9Pt31IXqZ3D3nD9Fsfj_Nx7NIMZF2kSqFgJRUgi1kJaRUkFU04QA6ZiwTQLkOW_gDz6hSMtGEV7pMEpZIrRRlQzTaelfOfvbad0VjvNJ1Da22vS9ixjMe8ywhAb3aospZ752uipUzDbhNQUnxnW4R0i126Qb6fCfuF40uf9mfOANwsQVsv_rX9AXNW4Ik</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2376727640</pqid></control><display><type>article</type><title>A Comparative Study on the Clinical Features of Coronavirus 2019 (COVID-19) Pneumonia With Other Pneumonias</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Zhao, Dahai ; Yao, Feifei ; Wang, Lijie ; Zheng, Ling ; Gao, Yongjun ; Ye, Jun ; Guo, Feng ; Zhao, Hui ; Gao, Rongbao</creator><creatorcontrib>Zhao, Dahai ; Yao, Feifei ; Wang, Lijie ; Zheng, Ling ; Gao, Yongjun ; Ye, Jun ; Guo, Feng ; Zhao, Hui ; Gao, Rongbao</creatorcontrib><description>Abstract
Background
A novel coronavirus (COVID-19) has raised world concern since it emerged in Wuhan, China in December 2019. The infection may result in severe pneumonia with clusters of illness onsets. Its impacts on public health make it paramount to clarify the clinical features with other pneumonias.
Methods
Nineteen COVID-19 and 15 other patients with pneumonia (non-COVID-19) in areas outside of Hubei were involved in this study. Both COVID-19 and non-COVID-19 patients were confirmed to be infected using throat swabs and/or sputa with/without COVID-2019 by real-time RT-PCR. We analyzed the demographic, epidemiological, clinical, and radiological features from those patients, and compared the differences between COVID-19 and non-COVID-19.
Results
All patients had a history of exposure to confirmed cases of COVID-19 or travel to Hubei before illness. The median (IQR) duration was 8 (6–11) and 5 (4–11) days from exposure to onset in COVID-19 and non-COVID-19 cases, respectively. The clinical symptoms were similar between COVID-19 and non-COVID-19. The most common symptoms were fever and cough. Fifteen (78.95%) COVID-19 but 4 (26.67%) non-COVID-19 patients had bilateral involvement while 17 COVID-19 patients (89.47%) but 1 non-COVID-19 patient (6.67%) had multiple mottling and ground-glass opacity on chest CT images. Compared with non-COVID-19, COVID-19 presents remarkably more abnormal laboratory tests, including AST, ALT, γ-GT, LDH, and α-HBDH.
Conclusions
The COVID-19 infection has onsets similar to other pneumonias. CT scan may be a reliable test for screening COVID-19 cases. Liver function damage is more frequent in COVID-19 than non-COVID-19 patients. LDH and α-HBDH may be considerable markers for evaluation of COVID-19.
COVID-19 infection caused similar onsets to other pneumonias. Chest tomography scan may be a reliable test for screening COVID-19 cases. Liver function damage is more frequent in COVID-19 than non-COVID-19. Lactate dehydrogenase and α-hydroxybutyric dehydrogenase may be considerable markers for evaluation of COVID-19.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciaa247</identifier><identifier>PMID: 32161968</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Betacoronavirus - pathogenicity ; China - epidemiology ; Coronavirus Infections - epidemiology ; Coronavirus Infections - virology ; Cough - epidemiology ; Cough - virology ; COVID-19 ; Female ; Fever - epidemiology ; Fever - virology ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia - epidemiology ; Pneumonia - virology ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - virology ; SARS-CoV-2 ; Tomography, X-Ray Computed - methods ; Travel</subject><ispartof>Clinical infectious diseases, 2020-07, Vol.71 (15), p.756-761</ispartof><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-cd88a50f83b9f899ca6f147aae23368a17e47a0f8a761cc94e07fed44349ecc13</citedby><cites>FETCH-LOGICAL-c385t-cd88a50f83b9f899ca6f147aae23368a17e47a0f8a761cc94e07fed44349ecc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32161968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Dahai</creatorcontrib><creatorcontrib>Yao, Feifei</creatorcontrib><creatorcontrib>Wang, Lijie</creatorcontrib><creatorcontrib>Zheng, Ling</creatorcontrib><creatorcontrib>Gao, Yongjun</creatorcontrib><creatorcontrib>Ye, Jun</creatorcontrib><creatorcontrib>Guo, Feng</creatorcontrib><creatorcontrib>Zhao, Hui</creatorcontrib><creatorcontrib>Gao, Rongbao</creatorcontrib><title>A Comparative Study on the Clinical Features of Coronavirus 2019 (COVID-19) Pneumonia With Other Pneumonias</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Abstract
Background
A novel coronavirus (COVID-19) has raised world concern since it emerged in Wuhan, China in December 2019. The infection may result in severe pneumonia with clusters of illness onsets. Its impacts on public health make it paramount to clarify the clinical features with other pneumonias.
Methods
Nineteen COVID-19 and 15 other patients with pneumonia (non-COVID-19) in areas outside of Hubei were involved in this study. Both COVID-19 and non-COVID-19 patients were confirmed to be infected using throat swabs and/or sputa with/without COVID-2019 by real-time RT-PCR. We analyzed the demographic, epidemiological, clinical, and radiological features from those patients, and compared the differences between COVID-19 and non-COVID-19.
Results
All patients had a history of exposure to confirmed cases of COVID-19 or travel to Hubei before illness. The median (IQR) duration was 8 (6–11) and 5 (4–11) days from exposure to onset in COVID-19 and non-COVID-19 cases, respectively. The clinical symptoms were similar between COVID-19 and non-COVID-19. The most common symptoms were fever and cough. Fifteen (78.95%) COVID-19 but 4 (26.67%) non-COVID-19 patients had bilateral involvement while 17 COVID-19 patients (89.47%) but 1 non-COVID-19 patient (6.67%) had multiple mottling and ground-glass opacity on chest CT images. Compared with non-COVID-19, COVID-19 presents remarkably more abnormal laboratory tests, including AST, ALT, γ-GT, LDH, and α-HBDH.
Conclusions
The COVID-19 infection has onsets similar to other pneumonias. CT scan may be a reliable test for screening COVID-19 cases. Liver function damage is more frequent in COVID-19 than non-COVID-19 patients. LDH and α-HBDH may be considerable markers for evaluation of COVID-19.
COVID-19 infection caused similar onsets to other pneumonias. Chest tomography scan may be a reliable test for screening COVID-19 cases. Liver function damage is more frequent in COVID-19 than non-COVID-19. Lactate dehydrogenase and α-hydroxybutyric dehydrogenase may be considerable markers for evaluation of COVID-19.</description><subject>Adult</subject><subject>Betacoronavirus - pathogenicity</subject><subject>China - epidemiology</subject><subject>Coronavirus Infections - epidemiology</subject><subject>Coronavirus Infections - virology</subject><subject>Cough - epidemiology</subject><subject>Cough - virology</subject><subject>COVID-19</subject><subject>Female</subject><subject>Fever - epidemiology</subject><subject>Fever - virology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pandemics</subject><subject>Pneumonia - epidemiology</subject><subject>Pneumonia - virology</subject><subject>Pneumonia, Viral - epidemiology</subject><subject>Pneumonia, Viral - virology</subject><subject>SARS-CoV-2</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Travel</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LwzAYh4MoTqcn75KTTKSaNG2THEd1OhhM8OtY3qUpi7bNTNrB_nsjm3rz8PJ-PTyHH0JnlFxTItmNMmUogDjhe-iIpoxHWSrpfphJKqJEMDFAx96_E0KpIOkhGrCYZlRm4gh9jHFumxU46Mxa46euLzfYtrhbapzXpjUKajzR0PVOe2yrQDvbwtq43uOYUIlH-fx1ehtReYkfW903tjWA30y3xPMgcX9Hf4IOKqi9Pt31IXqZ3D3nD9Fsfj_Nx7NIMZF2kSqFgJRUgi1kJaRUkFU04QA6ZiwTQLkOW_gDz6hSMtGEV7pMEpZIrRRlQzTaelfOfvbad0VjvNJ1Da22vS9ixjMe8ywhAb3aospZ752uipUzDbhNQUnxnW4R0i126Qb6fCfuF40uf9mfOANwsQVsv_rX9AXNW4Ik</recordid><startdate>20200728</startdate><enddate>20200728</enddate><creator>Zhao, Dahai</creator><creator>Yao, Feifei</creator><creator>Wang, Lijie</creator><creator>Zheng, Ling</creator><creator>Gao, Yongjun</creator><creator>Ye, Jun</creator><creator>Guo, Feng</creator><creator>Zhao, Hui</creator><creator>Gao, Rongbao</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200728</creationdate><title>A Comparative Study on the Clinical Features of Coronavirus 2019 (COVID-19) Pneumonia With Other Pneumonias</title><author>Zhao, Dahai ; Yao, Feifei ; Wang, Lijie ; Zheng, Ling ; Gao, Yongjun ; Ye, Jun ; Guo, Feng ; Zhao, Hui ; Gao, Rongbao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-cd88a50f83b9f899ca6f147aae23368a17e47a0f8a761cc94e07fed44349ecc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Betacoronavirus - pathogenicity</topic><topic>China - epidemiology</topic><topic>Coronavirus Infections - epidemiology</topic><topic>Coronavirus Infections - virology</topic><topic>Cough - epidemiology</topic><topic>Cough - virology</topic><topic>COVID-19</topic><topic>Female</topic><topic>Fever - epidemiology</topic><topic>Fever - virology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pandemics</topic><topic>Pneumonia - epidemiology</topic><topic>Pneumonia - virology</topic><topic>Pneumonia, Viral - epidemiology</topic><topic>Pneumonia, Viral - virology</topic><topic>SARS-CoV-2</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Travel</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Dahai</creatorcontrib><creatorcontrib>Yao, Feifei</creatorcontrib><creatorcontrib>Wang, Lijie</creatorcontrib><creatorcontrib>Zheng, Ling</creatorcontrib><creatorcontrib>Gao, Yongjun</creatorcontrib><creatorcontrib>Ye, Jun</creatorcontrib><creatorcontrib>Guo, Feng</creatorcontrib><creatorcontrib>Zhao, Hui</creatorcontrib><creatorcontrib>Gao, Rongbao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Dahai</au><au>Yao, Feifei</au><au>Wang, Lijie</au><au>Zheng, Ling</au><au>Gao, Yongjun</au><au>Ye, Jun</au><au>Guo, Feng</au><au>Zhao, Hui</au><au>Gao, Rongbao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Comparative Study on the Clinical Features of Coronavirus 2019 (COVID-19) Pneumonia With Other Pneumonias</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2020-07-28</date><risdate>2020</risdate><volume>71</volume><issue>15</issue><spage>756</spage><epage>761</epage><pages>756-761</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Abstract
Background
A novel coronavirus (COVID-19) has raised world concern since it emerged in Wuhan, China in December 2019. The infection may result in severe pneumonia with clusters of illness onsets. Its impacts on public health make it paramount to clarify the clinical features with other pneumonias.
Methods
Nineteen COVID-19 and 15 other patients with pneumonia (non-COVID-19) in areas outside of Hubei were involved in this study. Both COVID-19 and non-COVID-19 patients were confirmed to be infected using throat swabs and/or sputa with/without COVID-2019 by real-time RT-PCR. We analyzed the demographic, epidemiological, clinical, and radiological features from those patients, and compared the differences between COVID-19 and non-COVID-19.
Results
All patients had a history of exposure to confirmed cases of COVID-19 or travel to Hubei before illness. The median (IQR) duration was 8 (6–11) and 5 (4–11) days from exposure to onset in COVID-19 and non-COVID-19 cases, respectively. The clinical symptoms were similar between COVID-19 and non-COVID-19. The most common symptoms were fever and cough. Fifteen (78.95%) COVID-19 but 4 (26.67%) non-COVID-19 patients had bilateral involvement while 17 COVID-19 patients (89.47%) but 1 non-COVID-19 patient (6.67%) had multiple mottling and ground-glass opacity on chest CT images. Compared with non-COVID-19, COVID-19 presents remarkably more abnormal laboratory tests, including AST, ALT, γ-GT, LDH, and α-HBDH.
Conclusions
The COVID-19 infection has onsets similar to other pneumonias. CT scan may be a reliable test for screening COVID-19 cases. Liver function damage is more frequent in COVID-19 than non-COVID-19 patients. LDH and α-HBDH may be considerable markers for evaluation of COVID-19.
COVID-19 infection caused similar onsets to other pneumonias. Chest tomography scan may be a reliable test for screening COVID-19 cases. Liver function damage is more frequent in COVID-19 than non-COVID-19. Lactate dehydrogenase and α-hydroxybutyric dehydrogenase may be considerable markers for evaluation of COVID-19.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32161968</pmid><doi>10.1093/cid/ciaa247</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Betacoronavirus - pathogenicity China - epidemiology Coronavirus Infections - epidemiology Coronavirus Infections - virology Cough - epidemiology Cough - virology COVID-19 Female Fever - epidemiology Fever - virology Humans Male Middle Aged Pandemics Pneumonia - epidemiology Pneumonia - virology Pneumonia, Viral - epidemiology Pneumonia, Viral - virology SARS-CoV-2 Tomography, X-Ray Computed - methods Travel |
| title | A Comparative Study on the Clinical Features of Coronavirus 2019 (COVID-19) Pneumonia With Other Pneumonias |
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