Sigma‐1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury

Neuron‐immune interaction in the dorsal root ganglia (DRG) plays a pivotal role in the neuropathic pain development after nerve injury. Sigma‐1 receptor (Sig‐1R) is expressed by DRG neurons but its role in neuropathic pain is not fully understood. We investigated the effect of peripheral Sig‐1R on n...

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Veröffentlicht in:	The FASEB journal 2020-04, Vol.34 (4), p.5951-5966
Hauptverfasser:	Bravo‐Caparrós, Inmaculada, Ruiz‐Cantero, M. Carmen, Perazzoli, Gloria, Cronin, Shane J. F., Vela, José M., Hamed, Mohamed F., Penninger, Josef M., Baeyens, José M., Cobos, Enrique J., Nieto, Francisco R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATF3 Behavior, Animal CCL2 Disease Models, Animal Female Ganglia, Spinal - immunology Ganglia, Spinal - metabolism Ganglia, Spinal - pathology Hyperalgesia - etiology Hyperalgesia - metabolism Hyperalgesia - pathology IL‐6 Macrophages - immunology Macrophages - metabolism Macrophages - pathology Mice Mice, Knockout Neuralgia - etiology Neuralgia - metabolism Neuralgia - pathology neuroinflammation Neurons - immunology Neurons - metabolism Neurons - pathology Peripheral Nerve Injuries - complications Receptors, sigma - physiology Sigma-1 Receptor spared nerve injury
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