Highly Chemoselective and Enantioselective Synthesis of 3,4‑2H‑Pyrindin-2-ones by an NHC-Catalyzed [3 + 3] Cyclization

A highly chemoselective and enantioselective cyclization of γ-chloroenals and ketimines has been developed to synthesize enantiopure 3,4-2H-pyrindin-2-ones as major products. It is proposed that the intermediate enone IV reacted with an enamine to proceed with a [3 + 3] cyclization, thereby affordin...

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Veröffentlicht in:	Organic letters 2020-05, Vol.22 (9), p.3329-3334
Hauptverfasser:	Yan, Jun, Song, Zhaoxin, Zhao, Chengtao, Shi, Kuangxi, Yang, Limin, Zhong, Guofu
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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