PACAP ameliorates fertility in obese male mice via PKA/CREB pathway‐dependent Sirt1 activation and p53 deacetylation

Obesity is strongly linked to male infertility. Testicular spermatogenic cell apoptosis plays an important role in obesity‐related male infertility. Pituitary adenylate cyclase‐activating peptide (PACAP) has been recently shown to exhibit antiapoptotic and antidiabetic effects. However, the effects...

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Veröffentlicht in:	Journal of cellular physiology 2020-10, Vol.235 (10), p.7465-7483
Hauptverfasser:	Yan, Qiuxia, Huang, Hongke, Lu, Shiyin, Ou, Biqian, Feng, Jia, Shan, Wailan, Li, Huixian, Wang, Zixian, Hong, An, Ma, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acrosome reaction Activation Animals Antidiabetics Apoptosis Body weight Cell Line - chemistry Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Deacetylation Diabetes mellitus Down-Regulation - physiology Embryos Fertility Fertility - physiology High fat diet In vitro fertilization Infertility Infertility, Male - metabolism Lipids Male Male infertility Mice Mice, Inbred C57BL Mice, Obese Morphology Obesity Obesity - metabolism p53 p53 Protein PAC1 protein PACAP Palmitic acid Pituitary adenylate cyclase-activating polypeptide Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism Rodents Semen Serum lipids Signal Transduction - physiology Sirt1 SIRT1 protein Sirtuin 1 - metabolism Sperm Spermatozoa - metabolism Testes Testis - metabolism Tumor Suppressor Protein p53 - metabolism
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