Beyond heuristics: CFD‐based novel multiparameter scale‐up for geometrically disparate bioreactors demonstrated at industrial 2kL–10kL scales

The timely delivery of the most up‐to‐date medicines and drug products is essential for patients throughout the world. Successful scaling of the bioreactors used within the biopharmaceutical industry plays a large part in the quality and time to market of these products. Scale and topology differenc...

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Veröffentlicht in:	Biotechnology and bioengineering 2020-06, Vol.117 (6), p.1710-1723
Hauptverfasser:	Scully, James, Considine, Laura B., Smith, Mark T., McAlea, Eamonn, Jones, Nephi, O'Connell, Edel, Madsen, Emilee, Power, Martin, Mellors, Philip, Crowley, John, O'Leary, Niall, Carver, Scott, Van Plew, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopharmaceuticals bioreactor Bioreactors Blood vessels Cell culture CFD Computational fluid dynamics Computer applications Drug delivery systems Experimentation Fluid dynamics Hydrodynamics Mass transfer Material properties Mathematical models Medicine Problem solving Scaling Topology
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