Oncolytic poxvirus CF33-hNIS-ΔF14.5 favorably modulates tumor immune microenvironment and works synergistically with anti-PD-L1 antibody in a triple-negative breast cancer model

Triple-negative breast cancer is the most aggressive subtype of breast cancer and is difficult to treat. Breast cancer is considered to be poorly immunogenic and hence is less responsive to immunotherapies. We tested whether the oncolytic poxvirus CF33-hNIS-ΔF14.5 could modulate tumor immune microen...

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Veröffentlicht in:	Oncoimmunology 2020-01, Vol.9 (1), p.1729300-1729300
Hauptverfasser:	Chaurasiya, Shyambabu, Yang, Annie, Kang, Seonah, Lu, Jianming, Kim, Sang-In, Park, Anthony K., Sivanandam, Venkatesh, Zhang, Zhifang, Woo, Yanghee, Warner, Susanne G., Fong, Yuman
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B7-H1 Antigen - immunology Cell Line, Tumor Humans ICI Immunotherapy Mice Oncolytic Virotherapy Oncolytic virus Original Research TNBC Triple Negative Breast Neoplasms - therapy Tumor Microenvironment
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