The Vasorelaxant and Neuroprotective Effects of Mildronate in A Rabbit Subarachnoid Hemorrhage Model

The Vasorelaxant and Neuroprotective Effects of Mildronate in A Rabbit Subarachnoid Hemorrhage Model

To investigate the effects of an anti-ischemic agent, mildronate, on subarachnoid hemorrhage-induced vasospasm. Rabbits were randomly divided into four groups: control, subarachnoid hemorrhage (SAH), vehicle, and mildronate (n=8 animals per group). In the treatment group, 200 mg/kg of mildronate wer...

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Veröffentlicht in:Turkish neurosurgery 2020-01, Vol.30 (2), p.163-170
Hauptverfasser: Eser, Muhammed Taha, Bektasoglu, Pinar Kuru, Gurer, Bora, Bozkurt, Huseyin, Sorar, Mehmet, Ozturk, Ozden Caglar, Arikok, Ata Turker, Kertmen, Hayri
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container_end_page 170
container_issue 2
container_start_page 163
container_title Turkish neurosurgery
container_volume 30
creator Eser, Muhammed Taha
Bektasoglu, Pinar Kuru
Gurer, Bora
Bozkurt, Huseyin
Sorar, Mehmet
Ozturk, Ozden Caglar
Arikok, Ata Turker
Kertmen, Hayri
description To investigate the effects of an anti-ischemic agent, mildronate, on subarachnoid hemorrhage-induced vasospasm. Rabbits were randomly divided into four groups: control, subarachnoid hemorrhage (SAH), vehicle, and mildronate (n=8 animals per group). In the treatment group, 200 mg/kg of mildronate were intraperitoneally administered 5 minutes after the procedure and continued for 3 days as daily administrations of the same dose. At the end of the third day, the cerebrum, cerebellum, and brain stem were perfused, fixated, and removed for histopathological examination. Tissues were examined for arterial wall thickness, luminal area, and hippocampal neuronal degeneration. Mildronate group showed significantly increased luminal area and reduced wall thickness of the basilar artery compared with the subarachnoid hemorrhage group. In addition, the hippocampal cell degeneration score was significantly lower in the mildronate group than in the SAH and vehicle groups. These results show that mildronate exerts protective effects against SAH-induced vasospasm and secondary neural injury.
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title The Vasorelaxant and Neuroprotective Effects of Mildronate in A Rabbit Subarachnoid Hemorrhage Model
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