A bifunctional O-antigen polymerase structure reveals a new glycosyltransferase family

Lipopolysaccharide O-antigen is an attractive candidate for immunotherapeutic strategies targeting antibiotic-resistant Klebsiella pneumoniae . Several K. pneumoniae O-serotypes are based on a shared O2a-antigen backbone repeating unit: (→ 3)-α-Gal p -(1 → 3)-β-Gal f -(1 →). O2a antigen is synthesiz...

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Veröffentlicht in:	Nature chemical biology 2020-04, Vol.16 (4), p.450-457
Hauptverfasser:	Clarke, Bradley R., Ovchinnikova, Olga G., Sweeney, Ryan P., Kamski-Hennekam, Evelyn R., Gitalis, Russel, Mallette, Evan, Kelly, Steven D., Lowary, Todd L., Kimber, Matthew S., Whitfield, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	631/535 631/92/221 631/92/607 631/92/72 Amino Acid Sequence Antibiotic resistance Antibiotics Antigens ATP-Binding Cassette Transporters - metabolism Biochemical Engineering Biochemistry Bioorganic Chemistry Biosynthesis Cell Biology Cell Membrane - metabolism Cell surface Chemistry Chemistry and Materials Science Chemistry/Food Science Domains Food industry Food processing industry Glycosyltransferase Glycosyltransferases - metabolism Glycosyltransferases - physiology Hexosyltransferases Klebsiella Klebsiella pneumoniae Klebsiella pneumoniae - metabolism Lipopolysaccharides Lipopolysaccharides - chemistry O Antigens - metabolism O Antigens - ultrastructure Oligosaccharides Polymerization Polysaccharides Polysaccharides, Bacterial - chemistry Saccharides Serotypes Structural analysis
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