Prognostic Value and Therapeutic Implication of Laparoscopic Extraperitoneal Paraaortic Staging in Locally Advanced Cervical Cancer: A Spanish Multicenter Study
Purpose To assess the impact of laparoscopic extraperitoneal paraaortic staging in therapeutic planning and prognosis of patients with locally advanced cervical cancer (LACC) as compared with imaging staging. Methods Retrospective multicenter study of stage IB2 and IIA2 to IVA (FIGO 2009) LACC patie...
Gespeichert in:
| Veröffentlicht in: | Annals of surgical oncology 2020-08, Vol.27 (8), p.2829-2839 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2839 |
|---|---|
| container_issue | 8 |
| container_start_page | 2829 |
| container_title | Annals of surgical oncology |
| container_volume | 27 |
| creator | Díaz-Feijoo, Berta Torné, Aureli Tejerizo, Álvaro Benito, Virginia Hernández, Alicia Ruiz, Rubén Domingo, Santiago Luna-Guibourg, Rocío Llueca, Antonio Coronado, Pluvio Gilabert-Estelles, Juan Bebia, Vicente Gil-Ibáñez, Blanca Gil-Moreno, Antonio |
| description | Purpose
To assess the impact of laparoscopic extraperitoneal paraaortic staging in therapeutic planning and prognosis of patients with locally advanced cervical cancer (LACC) as compared with imaging staging.
Methods
Retrospective multicenter study of stage IB2 and IIA2 to IVA (FIGO 2009) LACC patients who were candidates for primary chemoradiotherapy. The study (surgical) group included 634 patients undergoing laparoscopic/robotic extraperitoneal paraaortic staging treated with extended-field radiotherapy (EFRT) if lymph node involvement was confirmed. The control (imaging) group included 288 patients treated with EFRT when lymph node involvement was suspected on positron emission tomography-computed tomography scans and/or magnetic resonance imaging.
Results
In the study group, a median of 13 (range 9–17) lymph nodes were removed, with a rate of positive paraaortic nodes of 18%, with metastatic size ≤ 5 mm in 20.4% of cases. Paraaortic EFRT was administered to 18% of patients in the study group and in 58% of controls. In 34% of patients from the surgical group, EFRT was modified according to surgical findings with respect to imaging staging. The median follow-up in the study and control groups was 3.7 and 4.8 years, respectively. In both groups, the overall survival and cancer-specific disease-free survival were similar. The time interval between diagnosis and starting EFRT was 18 days longer in the study group, without differences in overall survival as compared with controls (hazard ratio 1.00, 95% confidence interval 0.998–1.005;
p
= 0.307).
Conclusions
Laparoscopic extraperitoneal paraaortic staging in LACC patients is safe and modified therapeutic planning, allowing better selection of candidates for EFRT. |
| doi_str_mv | 10.1245/s10434-020-08329-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2375911749</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2419779401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-76b14a1f966de126e1ebdede443b76a91c5b6c1517d1163d8d731d38db89367a3</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxiMEoqXwAhyQJS69BDz-m3BbrQpUWkSlFq7WxPZuU2XtYCcV-zY8Kg5bQOLAyfbM7_tm5K-qXgJ9A0zItxmo4KKmjNa04ayt5aPqFGQpCdXA43KnqqlbpuRJ9SznO0pBcyqfViecgWRai9Pqx1WKuxDz1FvyFYfZEwyO3Nz6hKOfl-rlfhx6i1MfA4lbssERU8w2jqV38X1auNRPMXgcyBUmxJgW2fWEuz7sSB_IJlochgNZuXsM1juy9um-WA5kvbzTO7Ii1yOGPt-ST_NQ1D5MPhWL2R2eV0-2OGT_4uE8q768v7hZf6w3nz9crleb2nItp1qrDgTCtlXKeWDKg--cd14I3mmFLVjZKQsStANQ3DVOc3C8cV3TcqWRn1XnR98xxW-zz5PZ99n6YcDg45wNK2NaAC3agr7-B72LcwplO8MEtFq3gkKh2JGy5bty8lszpn6P6WCAmiU_c8zPlPzMr_yMLKJXD9Zzt_fuj-R3YAXgRyCXVtj59Hf2f2x_ApWUqAE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2419779401</pqid></control><display><type>article</type><title>Prognostic Value and Therapeutic Implication of Laparoscopic Extraperitoneal Paraaortic Staging in Locally Advanced Cervical Cancer: A Spanish Multicenter Study</title><source>MEDLINE</source><source>Springer Journals</source><creator>Díaz-Feijoo, Berta ; Torné, Aureli ; Tejerizo, Álvaro ; Benito, Virginia ; Hernández, Alicia ; Ruiz, Rubén ; Domingo, Santiago ; Luna-Guibourg, Rocío ; Llueca, Antonio ; Coronado, Pluvio ; Gilabert-Estelles, Juan ; Bebia, Vicente ; Gil-Ibáñez, Blanca ; Gil-Moreno, Antonio</creator><creatorcontrib>Díaz-Feijoo, Berta ; Torné, Aureli ; Tejerizo, Álvaro ; Benito, Virginia ; Hernández, Alicia ; Ruiz, Rubén ; Domingo, Santiago ; Luna-Guibourg, Rocío ; Llueca, Antonio ; Coronado, Pluvio ; Gilabert-Estelles, Juan ; Bebia, Vicente ; Gil-Ibáñez, Blanca ; Gil-Moreno, Antonio ; SEGO Spain-GOG Group ; the SEGO Spain-GOG Group</creatorcontrib><description>Purpose
To assess the impact of laparoscopic extraperitoneal paraaortic staging in therapeutic planning and prognosis of patients with locally advanced cervical cancer (LACC) as compared with imaging staging.
Methods
Retrospective multicenter study of stage IB2 and IIA2 to IVA (FIGO 2009) LACC patients who were candidates for primary chemoradiotherapy. The study (surgical) group included 634 patients undergoing laparoscopic/robotic extraperitoneal paraaortic staging treated with extended-field radiotherapy (EFRT) if lymph node involvement was confirmed. The control (imaging) group included 288 patients treated with EFRT when lymph node involvement was suspected on positron emission tomography-computed tomography scans and/or magnetic resonance imaging.
Results
In the study group, a median of 13 (range 9–17) lymph nodes were removed, with a rate of positive paraaortic nodes of 18%, with metastatic size ≤ 5 mm in 20.4% of cases. Paraaortic EFRT was administered to 18% of patients in the study group and in 58% of controls. In 34% of patients from the surgical group, EFRT was modified according to surgical findings with respect to imaging staging. The median follow-up in the study and control groups was 3.7 and 4.8 years, respectively. In both groups, the overall survival and cancer-specific disease-free survival were similar. The time interval between diagnosis and starting EFRT was 18 days longer in the study group, without differences in overall survival as compared with controls (hazard ratio 1.00, 95% confidence interval 0.998–1.005;
p
= 0.307).
Conclusions
Laparoscopic extraperitoneal paraaortic staging in LACC patients is safe and modified therapeutic planning, allowing better selection of candidates for EFRT.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-020-08329-5</identifier><identifier>PMID: 32152774</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Cervical cancer ; Chemoradiotherapy ; Computed tomography ; Female ; Gynecologic Oncology ; Humans ; Laparoscopy ; Lymph Node Excision ; Lymph nodes ; Lymph Nodes - diagnostic imaging ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic system ; Magnetic resonance imaging ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastases ; Neoplasm Staging ; Oncology ; Positron emission tomography ; Prognosis ; Radiation therapy ; Retrospective Studies ; Robotic surgery ; Surgery ; Surgical Oncology ; Survival ; Tomography ; Uterine Cervical Neoplasms - diagnostic imaging ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - therapy</subject><ispartof>Annals of surgical oncology, 2020-08, Vol.27 (8), p.2829-2839</ispartof><rights>Society of Surgical Oncology 2020</rights><rights>Society of Surgical Oncology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-76b14a1f966de126e1ebdede443b76a91c5b6c1517d1163d8d731d38db89367a3</citedby><cites>FETCH-LOGICAL-c375t-76b14a1f966de126e1ebdede443b76a91c5b6c1517d1163d8d731d38db89367a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-020-08329-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-020-08329-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32152774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Díaz-Feijoo, Berta</creatorcontrib><creatorcontrib>Torné, Aureli</creatorcontrib><creatorcontrib>Tejerizo, Álvaro</creatorcontrib><creatorcontrib>Benito, Virginia</creatorcontrib><creatorcontrib>Hernández, Alicia</creatorcontrib><creatorcontrib>Ruiz, Rubén</creatorcontrib><creatorcontrib>Domingo, Santiago</creatorcontrib><creatorcontrib>Luna-Guibourg, Rocío</creatorcontrib><creatorcontrib>Llueca, Antonio</creatorcontrib><creatorcontrib>Coronado, Pluvio</creatorcontrib><creatorcontrib>Gilabert-Estelles, Juan</creatorcontrib><creatorcontrib>Bebia, Vicente</creatorcontrib><creatorcontrib>Gil-Ibáñez, Blanca</creatorcontrib><creatorcontrib>Gil-Moreno, Antonio</creatorcontrib><creatorcontrib>SEGO Spain-GOG Group</creatorcontrib><creatorcontrib>the SEGO Spain-GOG Group</creatorcontrib><title>Prognostic Value and Therapeutic Implication of Laparoscopic Extraperitoneal Paraaortic Staging in Locally Advanced Cervical Cancer: A Spanish Multicenter Study</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Purpose
To assess the impact of laparoscopic extraperitoneal paraaortic staging in therapeutic planning and prognosis of patients with locally advanced cervical cancer (LACC) as compared with imaging staging.
Methods
Retrospective multicenter study of stage IB2 and IIA2 to IVA (FIGO 2009) LACC patients who were candidates for primary chemoradiotherapy. The study (surgical) group included 634 patients undergoing laparoscopic/robotic extraperitoneal paraaortic staging treated with extended-field radiotherapy (EFRT) if lymph node involvement was confirmed. The control (imaging) group included 288 patients treated with EFRT when lymph node involvement was suspected on positron emission tomography-computed tomography scans and/or magnetic resonance imaging.
Results
In the study group, a median of 13 (range 9–17) lymph nodes were removed, with a rate of positive paraaortic nodes of 18%, with metastatic size ≤ 5 mm in 20.4% of cases. Paraaortic EFRT was administered to 18% of patients in the study group and in 58% of controls. In 34% of patients from the surgical group, EFRT was modified according to surgical findings with respect to imaging staging. The median follow-up in the study and control groups was 3.7 and 4.8 years, respectively. In both groups, the overall survival and cancer-specific disease-free survival were similar. The time interval between diagnosis and starting EFRT was 18 days longer in the study group, without differences in overall survival as compared with controls (hazard ratio 1.00, 95% confidence interval 0.998–1.005;
p
= 0.307).
Conclusions
Laparoscopic extraperitoneal paraaortic staging in LACC patients is safe and modified therapeutic planning, allowing better selection of candidates for EFRT.</description><subject>Cervical cancer</subject><subject>Chemoradiotherapy</subject><subject>Computed tomography</subject><subject>Female</subject><subject>Gynecologic Oncology</subject><subject>Humans</subject><subject>Laparoscopy</subject><subject>Lymph Node Excision</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic system</subject><subject>Magnetic resonance imaging</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Positron emission tomography</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><subject>Robotic surgery</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival</subject><subject>Tomography</subject><subject>Uterine Cervical Neoplasms - diagnostic imaging</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - therapy</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc9u1DAQxiMEoqXwAhyQJS69BDz-m3BbrQpUWkSlFq7WxPZuU2XtYCcV-zY8Kg5bQOLAyfbM7_tm5K-qXgJ9A0zItxmo4KKmjNa04ayt5aPqFGQpCdXA43KnqqlbpuRJ9SznO0pBcyqfViecgWRai9Pqx1WKuxDz1FvyFYfZEwyO3Nz6hKOfl-rlfhx6i1MfA4lbssERU8w2jqV38X1auNRPMXgcyBUmxJgW2fWEuz7sSB_IJlochgNZuXsM1juy9um-WA5kvbzTO7Ii1yOGPt-ST_NQ1D5MPhWL2R2eV0-2OGT_4uE8q768v7hZf6w3nz9crleb2nItp1qrDgTCtlXKeWDKg--cd14I3mmFLVjZKQsStANQ3DVOc3C8cV3TcqWRn1XnR98xxW-zz5PZ99n6YcDg45wNK2NaAC3agr7-B72LcwplO8MEtFq3gkKh2JGy5bty8lszpn6P6WCAmiU_c8zPlPzMr_yMLKJXD9Zzt_fuj-R3YAXgRyCXVtj59Hf2f2x_ApWUqAE</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Díaz-Feijoo, Berta</creator><creator>Torné, Aureli</creator><creator>Tejerizo, Álvaro</creator><creator>Benito, Virginia</creator><creator>Hernández, Alicia</creator><creator>Ruiz, Rubén</creator><creator>Domingo, Santiago</creator><creator>Luna-Guibourg, Rocío</creator><creator>Llueca, Antonio</creator><creator>Coronado, Pluvio</creator><creator>Gilabert-Estelles, Juan</creator><creator>Bebia, Vicente</creator><creator>Gil-Ibáñez, Blanca</creator><creator>Gil-Moreno, Antonio</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200801</creationdate><title>Prognostic Value and Therapeutic Implication of Laparoscopic Extraperitoneal Paraaortic Staging in Locally Advanced Cervical Cancer: A Spanish Multicenter Study</title><author>Díaz-Feijoo, Berta ; Torné, Aureli ; Tejerizo, Álvaro ; Benito, Virginia ; Hernández, Alicia ; Ruiz, Rubén ; Domingo, Santiago ; Luna-Guibourg, Rocío ; Llueca, Antonio ; Coronado, Pluvio ; Gilabert-Estelles, Juan ; Bebia, Vicente ; Gil-Ibáñez, Blanca ; Gil-Moreno, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-76b14a1f966de126e1ebdede443b76a91c5b6c1517d1163d8d731d38db89367a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cervical cancer</topic><topic>Chemoradiotherapy</topic><topic>Computed tomography</topic><topic>Female</topic><topic>Gynecologic Oncology</topic><topic>Humans</topic><topic>Laparoscopy</topic><topic>Lymph Node Excision</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - diagnostic imaging</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic system</topic><topic>Magnetic resonance imaging</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Positron emission tomography</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Retrospective Studies</topic><topic>Robotic surgery</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival</topic><topic>Tomography</topic><topic>Uterine Cervical Neoplasms - diagnostic imaging</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Díaz-Feijoo, Berta</creatorcontrib><creatorcontrib>Torné, Aureli</creatorcontrib><creatorcontrib>Tejerizo, Álvaro</creatorcontrib><creatorcontrib>Benito, Virginia</creatorcontrib><creatorcontrib>Hernández, Alicia</creatorcontrib><creatorcontrib>Ruiz, Rubén</creatorcontrib><creatorcontrib>Domingo, Santiago</creatorcontrib><creatorcontrib>Luna-Guibourg, Rocío</creatorcontrib><creatorcontrib>Llueca, Antonio</creatorcontrib><creatorcontrib>Coronado, Pluvio</creatorcontrib><creatorcontrib>Gilabert-Estelles, Juan</creatorcontrib><creatorcontrib>Bebia, Vicente</creatorcontrib><creatorcontrib>Gil-Ibáñez, Blanca</creatorcontrib><creatorcontrib>Gil-Moreno, Antonio</creatorcontrib><creatorcontrib>SEGO Spain-GOG Group</creatorcontrib><creatorcontrib>the SEGO Spain-GOG Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Díaz-Feijoo, Berta</au><au>Torné, Aureli</au><au>Tejerizo, Álvaro</au><au>Benito, Virginia</au><au>Hernández, Alicia</au><au>Ruiz, Rubén</au><au>Domingo, Santiago</au><au>Luna-Guibourg, Rocío</au><au>Llueca, Antonio</au><au>Coronado, Pluvio</au><au>Gilabert-Estelles, Juan</au><au>Bebia, Vicente</au><au>Gil-Ibáñez, Blanca</au><au>Gil-Moreno, Antonio</au><aucorp>SEGO Spain-GOG Group</aucorp><aucorp>the SEGO Spain-GOG Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Value and Therapeutic Implication of Laparoscopic Extraperitoneal Paraaortic Staging in Locally Advanced Cervical Cancer: A Spanish Multicenter Study</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>27</volume><issue>8</issue><spage>2829</spage><epage>2839</epage><pages>2829-2839</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Purpose
To assess the impact of laparoscopic extraperitoneal paraaortic staging in therapeutic planning and prognosis of patients with locally advanced cervical cancer (LACC) as compared with imaging staging.
Methods
Retrospective multicenter study of stage IB2 and IIA2 to IVA (FIGO 2009) LACC patients who were candidates for primary chemoradiotherapy. The study (surgical) group included 634 patients undergoing laparoscopic/robotic extraperitoneal paraaortic staging treated with extended-field radiotherapy (EFRT) if lymph node involvement was confirmed. The control (imaging) group included 288 patients treated with EFRT when lymph node involvement was suspected on positron emission tomography-computed tomography scans and/or magnetic resonance imaging.
Results
In the study group, a median of 13 (range 9–17) lymph nodes were removed, with a rate of positive paraaortic nodes of 18%, with metastatic size ≤ 5 mm in 20.4% of cases. Paraaortic EFRT was administered to 18% of patients in the study group and in 58% of controls. In 34% of patients from the surgical group, EFRT was modified according to surgical findings with respect to imaging staging. The median follow-up in the study and control groups was 3.7 and 4.8 years, respectively. In both groups, the overall survival and cancer-specific disease-free survival were similar. The time interval between diagnosis and starting EFRT was 18 days longer in the study group, without differences in overall survival as compared with controls (hazard ratio 1.00, 95% confidence interval 0.998–1.005;
p
= 0.307).
Conclusions
Laparoscopic extraperitoneal paraaortic staging in LACC patients is safe and modified therapeutic planning, allowing better selection of candidates for EFRT.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32152774</pmid><doi>10.1245/s10434-020-08329-5</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2020-08, Vol.27 (8), p.2829-2839 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2375911749 |
| source | MEDLINE; Springer Journals |
| subjects | Cervical cancer Chemoradiotherapy Computed tomography Female Gynecologic Oncology Humans Laparoscopy Lymph Node Excision Lymph nodes Lymph Nodes - diagnostic imaging Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic system Magnetic resonance imaging Medical prognosis Medicine Medicine & Public Health Metastases Neoplasm Staging Oncology Positron emission tomography Prognosis Radiation therapy Retrospective Studies Robotic surgery Surgery Surgical Oncology Survival Tomography Uterine Cervical Neoplasms - diagnostic imaging Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - therapy |
| title | Prognostic Value and Therapeutic Implication of Laparoscopic Extraperitoneal Paraaortic Staging in Locally Advanced Cervical Cancer: A Spanish Multicenter Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T16%3A29%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20Value%20and%20Therapeutic%20Implication%20of%20Laparoscopic%20Extraperitoneal%20Paraaortic%20Staging%20in%20Locally%20Advanced%20Cervical%20Cancer:%20A%20Spanish%20Multicenter%20Study&rft.jtitle=Annals%20of%20surgical%20oncology&rft.au=D%C3%ADaz-Feijoo,%20Berta&rft.aucorp=SEGO%20Spain-GOG%20Group&rft.date=2020-08-01&rft.volume=27&rft.issue=8&rft.spage=2829&rft.epage=2839&rft.pages=2829-2839&rft.issn=1068-9265&rft.eissn=1534-4681&rft_id=info:doi/10.1245/s10434-020-08329-5&rft_dat=%3Cproquest_cross%3E2419779401%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2419779401&rft_id=info:pmid/32152774&rfr_iscdi=true |