Hyper-polyploid embryos survive after implantation in mice
Polyploids generated by natural whole genome duplication have served as a dynamic force in vertebrate evolution. As evidence for evolution, polyploid organisms exist generally, however there have been no reports of polyploid organisms in mammals. In mice, polyploid embryos under normal culture condi...
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| Veröffentlicht in: | Zygote (Cambridge) 2020-06, Vol.28 (3), p.247-249 |
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| container_title | Zygote (Cambridge) |
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| creator | Imai, Hiroyuki Iwamori, Tokuko Kusakabe, Ken Takeshi Kiso, Yasuo Ono, Etsuro Kano, Kiyoshi |
| description | Polyploids generated by natural whole genome duplication have served as a dynamic force in vertebrate evolution. As evidence for evolution, polyploid organisms exist generally, however there have been no reports of polyploid organisms in mammals. In mice, polyploid embryos under normal culture conditions normally develop to the blastocyst stage. Nevertheless, most tetraploid embryos degenerate after implantation, indicating that whole genome duplication produces harmful effects on normal development in mice. Most previous research on polyploidy has mainly focused on tetraploid embryos. Analysis of various ploidy outcomes is important to comprehend the effects of polyploidization on embryo development. The purpose of this present study was to discover the extent of the polyploidization effect on implantation and development in post-implantation embryos. This paper describes for the first time an octaploid embryo implanted in mice despite hyper-polyploidization, and indicates that these mammalian embryos have the ability to implant, and even develop, despite the harmfulness of extreme whole genome duplication. |
| doi_str_mv | 10.1017/S0967199420000064 |
| format | Article |
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As evidence for evolution, polyploid organisms exist generally, however there have been no reports of polyploid organisms in mammals. In mice, polyploid embryos under normal culture conditions normally develop to the blastocyst stage. Nevertheless, most tetraploid embryos degenerate after implantation, indicating that whole genome duplication produces harmful effects on normal development in mice. Most previous research on polyploidy has mainly focused on tetraploid embryos. Analysis of various ploidy outcomes is important to comprehend the effects of polyploidization on embryo development. The purpose of this present study was to discover the extent of the polyploidization effect on implantation and development in post-implantation embryos. 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| identifier | ISSN: 0967-1994 |
| ispartof | Zygote (Cambridge), 2020-06, Vol.28 (3), p.247-249 |
| issn | 0967-1994 1469-8730 |
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| source | MEDLINE; Cambridge Journals |
| subjects | Animals Blastocyst - cytology Blastocyst - metabolism Cell cycle Cell division Diploidy Embryo Implantation Embryo Transfer - methods Embryos Evolution Female Gene expression Genome - genetics Genomes Histocytochemistry - methods Implantation Mammals Mice, Inbred ICR Ploidy Polyploidy Reproduction (copying) Stem cells Tetraploidy Vertebrates |
| title | Hyper-polyploid embryos survive after implantation in mice |
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