Relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the medulla oblongata in multiple system atrophy
Purpose Neurodegeneration of the nucleus ambiguus and the dorsal vagal motor nucleus has been implicated in cardiac parasympathetic dysfunction in multiple system atrophy (MSA). The nucleus ambiguus and the dorsal vagal motor nucleus, which are located in the medulla oblongata (MO), control the auto...
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| Veröffentlicht in: | Clinical autonomic research 2020-06, Vol.30 (3), p.231-238 |
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| creator | Suzuki, Masashi Nakamura, Tomohiko Hirayama, Masaaki Ueda, Miki Imai, Eriko Harada, Yumiko Katsuno, Masahisa |
| description | Purpose
Neurodegeneration of the nucleus ambiguus and the dorsal vagal motor nucleus has been implicated in cardiac parasympathetic dysfunction in multiple system atrophy (MSA). The nucleus ambiguus and the dorsal vagal motor nucleus, which are located in the medulla oblongata (MO), control the autonomic—specifically, the parasympathetic—functions of the body. The aim of our study was to investigate the relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the MO in MSA by quantitatively analyzing magnetic resonance imaging (MRI) outcome measures.
Methods
We retrospectively assessed 40 consecutive patients with probable MSA and 25 age- and sex-matched controls. The anteroposterior diameter of the MO at two locations (MO diameter-A and -B) and the diameters of the midbrain and pons were measured by conventional MRI. A cardiac parasympathetic function score (CP-score) and cardiac sympathetic function score (CS-score) were generated by calculating the
z
-scores of multiple autonomic function tests. The relationship between the scores and the measured diameters of the brainstem was also investigated.
Results
The CP-score and CS-score were significantly lower in the patients with MSA than in the controls (CP-score: 0.61 ± 0.75 vs. − 0.38 ± 0.52,
p
|
| doi_str_mv | 10.1007/s10286-020-00675-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2375510837</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2375510837</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-d7f579cf212fd0ab08bad0a2448a5c6ddb58f4fbb4d225cf3ee7d59e470419093</originalsourceid><addsrcrecordid>eNp9kU1rFjEUhYMo9rX6B1xIwI2b0ZtMkkmWUvwoFATRdcjko2_KzGRMMsj8CP-zad-q0IWrE3Kfc3LJQeglgbcEYHhXCFApOqDQAYiBd-wROhBBVEe4gMfoAIqrTklOztCzUm4ACJc9eYrOekqYEIwd0K-vfjI1pqUc44pHX396v2BrsovG4tVkU_Z5NfXoa7TY7SVsi73lsVkcbtdNq89pTaVJTBk34-zbGadwN5-926bJ4DROabk21eC44Hmbalwnj8vefDM2tUUc9-foSTBT8S_u9Rx9__jh28Xn7urLp8uL91edZYzUzg2BD8oGSmhwYEaQo2lKGZOGW-HcyGVgYRyZo5Tb0Hs_OK48G4ARBao_R29OuWtOPzZfqp5jsb6tufi0FU37gXMCsh8a-voBepO2vLTtNGUglGBUykbRE2VzKiX7oNccZ5N3TUDflqVPZelWlr4rS7NmenUfvY3tl_5a_rTTgP4ElDZarn3-9_Z_Yn8DD4SjnA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2406964288</pqid></control><display><type>article</type><title>Relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the medulla oblongata in multiple system atrophy</title><source>SpringerLink_现刊</source><creator>Suzuki, Masashi ; Nakamura, Tomohiko ; Hirayama, Masaaki ; Ueda, Miki ; Imai, Eriko ; Harada, Yumiko ; Katsuno, Masahisa</creator><creatorcontrib>Suzuki, Masashi ; Nakamura, Tomohiko ; Hirayama, Masaaki ; Ueda, Miki ; Imai, Eriko ; Harada, Yumiko ; Katsuno, Masahisa</creatorcontrib><description>Purpose
Neurodegeneration of the nucleus ambiguus and the dorsal vagal motor nucleus has been implicated in cardiac parasympathetic dysfunction in multiple system atrophy (MSA). The nucleus ambiguus and the dorsal vagal motor nucleus, which are located in the medulla oblongata (MO), control the autonomic—specifically, the parasympathetic—functions of the body. The aim of our study was to investigate the relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the MO in MSA by quantitatively analyzing magnetic resonance imaging (MRI) outcome measures.
Methods
We retrospectively assessed 40 consecutive patients with probable MSA and 25 age- and sex-matched controls. The anteroposterior diameter of the MO at two locations (MO diameter-A and -B) and the diameters of the midbrain and pons were measured by conventional MRI. A cardiac parasympathetic function score (CP-score) and cardiac sympathetic function score (CS-score) were generated by calculating the
z
-scores of multiple autonomic function tests. The relationship between the scores and the measured diameters of the brainstem was also investigated.
Results
The CP-score and CS-score were significantly lower in the patients with MSA than in the controls (CP-score: 0.61 ± 0.75 vs. − 0.38 ± 0.52,
p
< 0.001; CS-score: 0.91 ± 1.06 vs. − 0.57 ± 1.07,
p
< 0.001). Also, in the patients with MSA, the CP-score was significantly correlated with MO diameter-A (
r
= 0.40,
p
= 0.010), and the CS-score was significantly correlated with the diameter of the midbrain (
r
= 0.33,
p
= 0.038).
Conclusion
The anteroposterior diameter of the MO is a potential imaging marker of parasympathetic dysfunction in MSA.</description><identifier>ISSN: 0959-9851</identifier><identifier>EISSN: 1619-1560</identifier><identifier>DOI: 10.1007/s10286-020-00675-4</identifier><identifier>PMID: 32146644</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Atrophy ; Autonomic nervous system ; Brain stem ; Cardiology ; Diabetes ; Endocrinology ; Gastroenterology ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Medulla oblongata ; Mesencephalon ; Motor nuclei ; Neurodegeneration ; Neurology ; Nucleus ambiguus ; Ophthalmology ; Parasympathetic nervous system ; Pons ; Research Article ; Vagus nerve</subject><ispartof>Clinical autonomic research, 2020-06, Vol.30 (3), p.231-238</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-d7f579cf212fd0ab08bad0a2448a5c6ddb58f4fbb4d225cf3ee7d59e470419093</citedby><cites>FETCH-LOGICAL-c441t-d7f579cf212fd0ab08bad0a2448a5c6ddb58f4fbb4d225cf3ee7d59e470419093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10286-020-00675-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10286-020-00675-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32146644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Masashi</creatorcontrib><creatorcontrib>Nakamura, Tomohiko</creatorcontrib><creatorcontrib>Hirayama, Masaaki</creatorcontrib><creatorcontrib>Ueda, Miki</creatorcontrib><creatorcontrib>Imai, Eriko</creatorcontrib><creatorcontrib>Harada, Yumiko</creatorcontrib><creatorcontrib>Katsuno, Masahisa</creatorcontrib><title>Relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the medulla oblongata in multiple system atrophy</title><title>Clinical autonomic research</title><addtitle>Clin Auton Res</addtitle><addtitle>Clin Auton Res</addtitle><description>Purpose
Neurodegeneration of the nucleus ambiguus and the dorsal vagal motor nucleus has been implicated in cardiac parasympathetic dysfunction in multiple system atrophy (MSA). The nucleus ambiguus and the dorsal vagal motor nucleus, which are located in the medulla oblongata (MO), control the autonomic—specifically, the parasympathetic—functions of the body. The aim of our study was to investigate the relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the MO in MSA by quantitatively analyzing magnetic resonance imaging (MRI) outcome measures.
Methods
We retrospectively assessed 40 consecutive patients with probable MSA and 25 age- and sex-matched controls. The anteroposterior diameter of the MO at two locations (MO diameter-A and -B) and the diameters of the midbrain and pons were measured by conventional MRI. A cardiac parasympathetic function score (CP-score) and cardiac sympathetic function score (CS-score) were generated by calculating the
z
-scores of multiple autonomic function tests. The relationship between the scores and the measured diameters of the brainstem was also investigated.
Results
The CP-score and CS-score were significantly lower in the patients with MSA than in the controls (CP-score: 0.61 ± 0.75 vs. − 0.38 ± 0.52,
p
< 0.001; CS-score: 0.91 ± 1.06 vs. − 0.57 ± 1.07,
p
< 0.001). Also, in the patients with MSA, the CP-score was significantly correlated with MO diameter-A (
r
= 0.40,
p
= 0.010), and the CS-score was significantly correlated with the diameter of the midbrain (
r
= 0.33,
p
= 0.038).
Conclusion
The anteroposterior diameter of the MO is a potential imaging marker of parasympathetic dysfunction in MSA.</description><subject>Atrophy</subject><subject>Autonomic nervous system</subject><subject>Brain stem</subject><subject>Cardiology</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Gastroenterology</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medulla oblongata</subject><subject>Mesencephalon</subject><subject>Motor nuclei</subject><subject>Neurodegeneration</subject><subject>Neurology</subject><subject>Nucleus ambiguus</subject><subject>Ophthalmology</subject><subject>Parasympathetic nervous system</subject><subject>Pons</subject><subject>Research Article</subject><subject>Vagus nerve</subject><issn>0959-9851</issn><issn>1619-1560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU1rFjEUhYMo9rX6B1xIwI2b0ZtMkkmWUvwoFATRdcjko2_KzGRMMsj8CP-zad-q0IWrE3Kfc3LJQeglgbcEYHhXCFApOqDQAYiBd-wROhBBVEe4gMfoAIqrTklOztCzUm4ACJc9eYrOekqYEIwd0K-vfjI1pqUc44pHX396v2BrsovG4tVkU_Z5NfXoa7TY7SVsi73lsVkcbtdNq89pTaVJTBk34-zbGadwN5-926bJ4DROabk21eC44Hmbalwnj8vefDM2tUUc9-foSTBT8S_u9Rx9__jh28Xn7urLp8uL91edZYzUzg2BD8oGSmhwYEaQo2lKGZOGW-HcyGVgYRyZo5Tb0Hs_OK48G4ARBao_R29OuWtOPzZfqp5jsb6tufi0FU37gXMCsh8a-voBepO2vLTtNGUglGBUykbRE2VzKiX7oNccZ5N3TUDflqVPZelWlr4rS7NmenUfvY3tl_5a_rTTgP4ElDZarn3-9_Z_Yn8DD4SjnA</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Suzuki, Masashi</creator><creator>Nakamura, Tomohiko</creator><creator>Hirayama, Masaaki</creator><creator>Ueda, Miki</creator><creator>Imai, Eriko</creator><creator>Harada, Yumiko</creator><creator>Katsuno, Masahisa</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20200601</creationdate><title>Relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the medulla oblongata in multiple system atrophy</title><author>Suzuki, Masashi ; Nakamura, Tomohiko ; Hirayama, Masaaki ; Ueda, Miki ; Imai, Eriko ; Harada, Yumiko ; Katsuno, Masahisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-d7f579cf212fd0ab08bad0a2448a5c6ddb58f4fbb4d225cf3ee7d59e470419093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Atrophy</topic><topic>Autonomic nervous system</topic><topic>Brain stem</topic><topic>Cardiology</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Gastroenterology</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medulla oblongata</topic><topic>Mesencephalon</topic><topic>Motor nuclei</topic><topic>Neurodegeneration</topic><topic>Neurology</topic><topic>Nucleus ambiguus</topic><topic>Ophthalmology</topic><topic>Parasympathetic nervous system</topic><topic>Pons</topic><topic>Research Article</topic><topic>Vagus nerve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Masashi</creatorcontrib><creatorcontrib>Nakamura, Tomohiko</creatorcontrib><creatorcontrib>Hirayama, Masaaki</creatorcontrib><creatorcontrib>Ueda, Miki</creatorcontrib><creatorcontrib>Imai, Eriko</creatorcontrib><creatorcontrib>Harada, Yumiko</creatorcontrib><creatorcontrib>Katsuno, Masahisa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical autonomic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Masashi</au><au>Nakamura, Tomohiko</au><au>Hirayama, Masaaki</au><au>Ueda, Miki</au><au>Imai, Eriko</au><au>Harada, Yumiko</au><au>Katsuno, Masahisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the medulla oblongata in multiple system atrophy</atitle><jtitle>Clinical autonomic research</jtitle><stitle>Clin Auton Res</stitle><addtitle>Clin Auton Res</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>30</volume><issue>3</issue><spage>231</spage><epage>238</epage><pages>231-238</pages><issn>0959-9851</issn><eissn>1619-1560</eissn><abstract>Purpose
Neurodegeneration of the nucleus ambiguus and the dorsal vagal motor nucleus has been implicated in cardiac parasympathetic dysfunction in multiple system atrophy (MSA). The nucleus ambiguus and the dorsal vagal motor nucleus, which are located in the medulla oblongata (MO), control the autonomic—specifically, the parasympathetic—functions of the body. The aim of our study was to investigate the relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the MO in MSA by quantitatively analyzing magnetic resonance imaging (MRI) outcome measures.
Methods
We retrospectively assessed 40 consecutive patients with probable MSA and 25 age- and sex-matched controls. The anteroposterior diameter of the MO at two locations (MO diameter-A and -B) and the diameters of the midbrain and pons were measured by conventional MRI. A cardiac parasympathetic function score (CP-score) and cardiac sympathetic function score (CS-score) were generated by calculating the
z
-scores of multiple autonomic function tests. The relationship between the scores and the measured diameters of the brainstem was also investigated.
Results
The CP-score and CS-score were significantly lower in the patients with MSA than in the controls (CP-score: 0.61 ± 0.75 vs. − 0.38 ± 0.52,
p
< 0.001; CS-score: 0.91 ± 1.06 vs. − 0.57 ± 1.07,
p
< 0.001). Also, in the patients with MSA, the CP-score was significantly correlated with MO diameter-A (
r
= 0.40,
p
= 0.010), and the CS-score was significantly correlated with the diameter of the midbrain (
r
= 0.33,
p
= 0.038).
Conclusion
The anteroposterior diameter of the MO is a potential imaging marker of parasympathetic dysfunction in MSA.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32146644</pmid><doi>10.1007/s10286-020-00675-4</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinical autonomic research, 2020-06, Vol.30 (3), p.231-238 |
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| subjects | Atrophy Autonomic nervous system Brain stem Cardiology Diabetes Endocrinology Gastroenterology Magnetic resonance imaging Medicine Medicine & Public Health Medulla oblongata Mesencephalon Motor nuclei Neurodegeneration Neurology Nucleus ambiguus Ophthalmology Parasympathetic nervous system Pons Research Article Vagus nerve |
| title | Relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the medulla oblongata in multiple system atrophy |
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