The effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials
•Probiotic supplementation on mental health in psychiatric disorders was evaluated.•Probiotic supplementation improved mental health.•Probiotic supplementation decreased inflammatory markers. In the current meta-analysis of randomized controlled trials (RCTs), the effects of probiotic supplementatio...
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| Veröffentlicht in: | Complementary therapies in medicine 2020-03, Vol.49, p.102361-102361, Article 102361 |
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| creator | Amirani, Elaheh Milajerdi, Alireza Mirzaei, Hamed Jamilian, Hamidreza Mansournia, Mohammad Ali Hallajzadeh, Jamal Ghaderi, Amir |
| description | •Probiotic supplementation on mental health in psychiatric disorders was evaluated.•Probiotic supplementation improved mental health.•Probiotic supplementation decreased inflammatory markers.
In the current meta-analysis of randomized controlled trials (RCTs), the effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders were assessed.
The following databases were search up to February 2019: PubMed, Scopus, Web of Science, Google scholar and Cochrane Central Register of Controlled Trials.
Twelve studies were included in the current meta-analysis. The findings demonstrated that probiotic supplementation resulted in a significant reduction in Hamilton Depression Rating Scale (HAMD) [Weighted Mean Difference (WMD): -9.60; 95 % CI: -10.08, -9.11]. In addition, a significant reduction in C-reactive protein (CRP) (WMD: -1.59; 95 % CI: -2.22, -0.97), interleukin 10 (IL-10) (WMD: -0.29; 95 % CI: -0.48, -0.11) and malondialdehyde (MDA) levels (WMD: -0.38; 95 % CI: -0.63, -0.13) was found after probiotics supplementation. No significant change was seen in Beck Depression Inventory (BDI) score (WMD: -11.17; 95 % CI: -24.99, 2.65), tumor necrosis factor-α (TNF-α) (WMD: -0.12; 95 % CI: -0.20, -0.05), IL-1B (WMD: -0.34; 95 % CI: -1.43, 0.74), IL-6 (WMD: 0.03; 95 % CI: -0.32, 0.38), nitric oxide (NO) (WMD: -0.54; 95 % CI: -2.16, 1.08), glutathione (GSH) (WMD: 46.79; 95 % CI: -17.25, 110.83) and total antioxidant capacity (TAC) levels (WMD: 15.21; 95 % CI: -59.96, 90.37) after probiotics supplementation.
Overall, the current meta-analysis demonstrated that taking probiotic by patients with psychiatric disorders had beneficial effects on HAMD, CRP, IL-10 and MDA levels, but it did not affect BDI score, other markers of inflammation and oxidative stress. |
| doi_str_mv | 10.1016/j.ctim.2020.102361 |
| format | Article |
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In the current meta-analysis of randomized controlled trials (RCTs), the effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders were assessed.
The following databases were search up to February 2019: PubMed, Scopus, Web of Science, Google scholar and Cochrane Central Register of Controlled Trials.
Twelve studies were included in the current meta-analysis. The findings demonstrated that probiotic supplementation resulted in a significant reduction in Hamilton Depression Rating Scale (HAMD) [Weighted Mean Difference (WMD): -9.60; 95 % CI: -10.08, -9.11]. In addition, a significant reduction in C-reactive protein (CRP) (WMD: -1.59; 95 % CI: -2.22, -0.97), interleukin 10 (IL-10) (WMD: -0.29; 95 % CI: -0.48, -0.11) and malondialdehyde (MDA) levels (WMD: -0.38; 95 % CI: -0.63, -0.13) was found after probiotics supplementation. No significant change was seen in Beck Depression Inventory (BDI) score (WMD: -11.17; 95 % CI: -24.99, 2.65), tumor necrosis factor-α (TNF-α) (WMD: -0.12; 95 % CI: -0.20, -0.05), IL-1B (WMD: -0.34; 95 % CI: -1.43, 0.74), IL-6 (WMD: 0.03; 95 % CI: -0.32, 0.38), nitric oxide (NO) (WMD: -0.54; 95 % CI: -2.16, 1.08), glutathione (GSH) (WMD: 46.79; 95 % CI: -17.25, 110.83) and total antioxidant capacity (TAC) levels (WMD: 15.21; 95 % CI: -59.96, 90.37) after probiotics supplementation.
Overall, the current meta-analysis demonstrated that taking probiotic by patients with psychiatric disorders had beneficial effects on HAMD, CRP, IL-10 and MDA levels, but it did not affect BDI score, other markers of inflammation and oxidative stress.</description><identifier>ISSN: 0965-2299</identifier><identifier>EISSN: 1873-6963</identifier><identifier>DOI: 10.1016/j.ctim.2020.102361</identifier><identifier>PMID: 32147043</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Alzheimer's disease ; Antioxidants ; Anxiety ; Bias ; Biomarkers ; Body composition ; C-reactive protein ; Clinical trials ; Disorders ; Gene expression ; Glutathione ; IL-1β ; Inflammation ; Interleukin 1 ; Interleukin 10 ; Interleukin 6 ; Interleukins ; Malondialdehyde ; Mental depression ; Mental disorders ; Mental health ; Meta-analysis ; Metabolism ; Nitric oxide ; Oxidative stress ; Probiotic supplementation ; Probiotics ; Psychiatric disorders ; Randomization ; Reduction ; Schizophrenia ; Search engines ; Supplements ; Systematic review ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Complementary therapies in medicine, 2020-03, Vol.49, p.102361-102361, Article 102361</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>2020. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-f69a95a6457650352748983a6933a79c4f8d6227a9c612560056850f6b344c8a3</citedby><cites>FETCH-LOGICAL-c384t-f69a95a6457650352748983a6933a79c4f8d6227a9c612560056850f6b344c8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0965229920300935$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32147043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amirani, Elaheh</creatorcontrib><creatorcontrib>Milajerdi, Alireza</creatorcontrib><creatorcontrib>Mirzaei, Hamed</creatorcontrib><creatorcontrib>Jamilian, Hamidreza</creatorcontrib><creatorcontrib>Mansournia, Mohammad Ali</creatorcontrib><creatorcontrib>Hallajzadeh, Jamal</creatorcontrib><creatorcontrib>Ghaderi, Amir</creatorcontrib><title>The effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials</title><title>Complementary therapies in medicine</title><addtitle>Complement Ther Med</addtitle><description>•Probiotic supplementation on mental health in psychiatric disorders was evaluated.•Probiotic supplementation improved mental health.•Probiotic supplementation decreased inflammatory markers.
In the current meta-analysis of randomized controlled trials (RCTs), the effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders were assessed.
The following databases were search up to February 2019: PubMed, Scopus, Web of Science, Google scholar and Cochrane Central Register of Controlled Trials.
Twelve studies were included in the current meta-analysis. The findings demonstrated that probiotic supplementation resulted in a significant reduction in Hamilton Depression Rating Scale (HAMD) [Weighted Mean Difference (WMD): -9.60; 95 % CI: -10.08, -9.11]. In addition, a significant reduction in C-reactive protein (CRP) (WMD: -1.59; 95 % CI: -2.22, -0.97), interleukin 10 (IL-10) (WMD: -0.29; 95 % CI: -0.48, -0.11) and malondialdehyde (MDA) levels (WMD: -0.38; 95 % CI: -0.63, -0.13) was found after probiotics supplementation. No significant change was seen in Beck Depression Inventory (BDI) score (WMD: -11.17; 95 % CI: -24.99, 2.65), tumor necrosis factor-α (TNF-α) (WMD: -0.12; 95 % CI: -0.20, -0.05), IL-1B (WMD: -0.34; 95 % CI: -1.43, 0.74), IL-6 (WMD: 0.03; 95 % CI: -0.32, 0.38), nitric oxide (NO) (WMD: -0.54; 95 % CI: -2.16, 1.08), glutathione (GSH) (WMD: 46.79; 95 % CI: -17.25, 110.83) and total antioxidant capacity (TAC) levels (WMD: 15.21; 95 % CI: -59.96, 90.37) after probiotics supplementation.
Overall, the current meta-analysis demonstrated that taking probiotic by patients with psychiatric disorders had beneficial effects on HAMD, CRP, IL-10 and MDA levels, but it did not affect BDI score, other markers of inflammation and oxidative stress.</description><subject>Alzheimer's disease</subject><subject>Antioxidants</subject><subject>Anxiety</subject><subject>Bias</subject><subject>Biomarkers</subject><subject>Body composition</subject><subject>C-reactive protein</subject><subject>Clinical trials</subject><subject>Disorders</subject><subject>Gene expression</subject><subject>Glutathione</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Interleukin 1</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Malondialdehyde</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Meta-analysis</subject><subject>Metabolism</subject><subject>Nitric oxide</subject><subject>Oxidative stress</subject><subject>Probiotic supplementation</subject><subject>Probiotics</subject><subject>Psychiatric disorders</subject><subject>Randomization</subject><subject>Reduction</subject><subject>Schizophrenia</subject><subject>Search engines</subject><subject>Supplements</subject><subject>Systematic review</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis 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probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials</title><author>Amirani, Elaheh ; Milajerdi, Alireza ; Mirzaei, Hamed ; Jamilian, Hamidreza ; Mansournia, Mohammad Ali ; Hallajzadeh, Jamal ; Ghaderi, Amir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-f69a95a6457650352748983a6933a79c4f8d6227a9c612560056850f6b344c8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alzheimer's disease</topic><topic>Antioxidants</topic><topic>Anxiety</topic><topic>Bias</topic><topic>Biomarkers</topic><topic>Body composition</topic><topic>C-reactive protein</topic><topic>Clinical trials</topic><topic>Disorders</topic><topic>Gene 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amirani, Elaheh</au><au>Milajerdi, Alireza</au><au>Mirzaei, Hamed</au><au>Jamilian, Hamidreza</au><au>Mansournia, Mohammad Ali</au><au>Hallajzadeh, Jamal</au><au>Ghaderi, Amir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials</atitle><jtitle>Complementary therapies in medicine</jtitle><addtitle>Complement Ther Med</addtitle><date>2020-03</date><risdate>2020</risdate><volume>49</volume><spage>102361</spage><epage>102361</epage><pages>102361-102361</pages><artnum>102361</artnum><issn>0965-2299</issn><eissn>1873-6963</eissn><abstract>•Probiotic supplementation on mental health in psychiatric disorders was evaluated.•Probiotic supplementation improved mental health.•Probiotic supplementation decreased inflammatory markers.
In the current meta-analysis of randomized controlled trials (RCTs), the effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders were assessed.
The following databases were search up to February 2019: PubMed, Scopus, Web of Science, Google scholar and Cochrane Central Register of Controlled Trials.
Twelve studies were included in the current meta-analysis. The findings demonstrated that probiotic supplementation resulted in a significant reduction in Hamilton Depression Rating Scale (HAMD) [Weighted Mean Difference (WMD): -9.60; 95 % CI: -10.08, -9.11]. In addition, a significant reduction in C-reactive protein (CRP) (WMD: -1.59; 95 % CI: -2.22, -0.97), interleukin 10 (IL-10) (WMD: -0.29; 95 % CI: -0.48, -0.11) and malondialdehyde (MDA) levels (WMD: -0.38; 95 % CI: -0.63, -0.13) was found after probiotics supplementation. No significant change was seen in Beck Depression Inventory (BDI) score (WMD: -11.17; 95 % CI: -24.99, 2.65), tumor necrosis factor-α (TNF-α) (WMD: -0.12; 95 % CI: -0.20, -0.05), IL-1B (WMD: -0.34; 95 % CI: -1.43, 0.74), IL-6 (WMD: 0.03; 95 % CI: -0.32, 0.38), nitric oxide (NO) (WMD: -0.54; 95 % CI: -2.16, 1.08), glutathione (GSH) (WMD: 46.79; 95 % CI: -17.25, 110.83) and total antioxidant capacity (TAC) levels (WMD: 15.21; 95 % CI: -59.96, 90.37) after probiotics supplementation.
Overall, the current meta-analysis demonstrated that taking probiotic by patients with psychiatric disorders had beneficial effects on HAMD, CRP, IL-10 and MDA levels, but it did not affect BDI score, other markers of inflammation and oxidative stress.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>32147043</pmid><doi>10.1016/j.ctim.2020.102361</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Complementary therapies in medicine, 2020-03, Vol.49, p.102361-102361, Article 102361 |
| issn | 0965-2299 1873-6963 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Alzheimer's disease Antioxidants Anxiety Bias Biomarkers Body composition C-reactive protein Clinical trials Disorders Gene expression Glutathione IL-1β Inflammation Interleukin 1 Interleukin 10 Interleukin 6 Interleukins Malondialdehyde Mental depression Mental disorders Mental health Meta-analysis Metabolism Nitric oxide Oxidative stress Probiotic supplementation Probiotics Psychiatric disorders Randomization Reduction Schizophrenia Search engines Supplements Systematic review Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | The effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials |
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