Neurobiological Mechanisms of Autism Spectrum Disorder and Epilepsy, Insights from Animal Models

•Autism and epilepsy are two neurodevelopmental disorders that have a high comorbidity rate.•Current research indicate that common neurodevelopmental mechanisms exist.•Animal models of the comorbidity point to main common pathways affected, mTOR, E/I imbalance and synaptic plasticity. Autism Spectru...

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Veröffentlicht in:	Neuroscience 2020-10, Vol.445, p.69-82
Hauptverfasser:	Sierra-Arregui, Teresa, Llorente, Javier, Giménez Minguez, Paula, Tønnesen, Jan, Peñagarikano, Olga
Format:	Artikel
Sprache:	eng
Schlagworte:	animal model Animals autism Autism Spectrum Disorder - epidemiology Autism Spectrum Disorder - genetics Comorbidity epilepsy Epilepsy - epidemiology Epilepsy - genetics Neurobiology Neurodevelopmental Disorders seizure social behavior
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