The use of extracorporeal membrane oxygenation in human immunodeficiency virus–positive patients: a review of a multicenter database
Aim: We chose to evaluate the survival of extracorporeal membrane oxygenation among patients with human immunodeficiency virus in a multicenter registry. Methods: Retrospective case review of the Extracorporeal Life Support Organization Registry respiratory failure of all patients with human immunod...
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| Veröffentlicht in: | Perfusion 2020-11, Vol.35 (8), p.772-777 |
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| creator | Brogan, Thomas V Thiagarajan, Ravi R Lorusso, Roberto McMullan, D Michael Di Nardo, Matteo Ogino, Mark T Dalton, Heidi J Burke, Christopher R Capatos, Gerry |
| description | Aim:
We chose to evaluate the survival of extracorporeal membrane oxygenation among patients with human immunodeficiency virus in a multicenter registry.
Methods:
Retrospective case review of the Extracorporeal Life Support Organization Registry respiratory failure of all patients with human immunodeficiency virus supported with extracorporeal membrane oxygenation.
Results:
A total of 126 patients were included. Survival to discharge was 36%. Eight infants were supported with extracorporeal membrane oxygenation and three (37.5%) survived to discharge. Respiratory extracorporeal membrane oxygenation was the primary indication (78%) with a 39% survival, while cardiac and extracorporeal cardiopulmonary resuscitation indications accounted for 16% and 6% of patients with survivals of 30% and 12.5%, respectively. These differences did not reach significance. There were no significant differences between survivors and non-survivors in demographic data, but non-survivors had significantly more non–human immunodeficiency virus pre–extracorporeal membrane oxygenation infections than survivors. There were no differences in other pre–extracorporeal membrane oxygenation supportive therapies, mechanical ventilator settings, or arterial blood gas results between survivors and non-survivors. The median duration of mechanical ventilation prior to cannulation was 52 (interquartile range: 13-140) hours, while the median duration of the extracorporeal membrane oxygenation exposure was 237 (interquartile range: 125-622) hours. Ventilator settings were significantly lower after 24 hours compared to pre–extracorporeal membrane oxygenation settings. Complications during extracorporeal membrane oxygenation exposure including receipt of renal replacement therapy, inotropic infusions, and cardiopulmonary resuscitation were more common among non-survivors compared to survivors. Central nervous system complications were rare.
Conclusion:
Survival among patients with human immunodeficiency virus infection who receive extracorporeal membrane oxygenation was less than 40%. Infections before extracorporeal membrane oxygenation cannulation occurred more often in non-survivors. The receipt of renal replacement therapy, inotropic infusions, or cardiopulmonary resuscitation during extracorporeal membrane oxygenation was associated with worse outcome. |
| doi_str_mv | 10.1177/0267659120906966 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2374376537</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0267659120906966</sage_id><sourcerecordid>2463953842</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-356e297da0709d5b80eb727e0e9b96f814dc23e81f2e30a6287c60c1a93c714e3</originalsourceid><addsrcrecordid>eNp1kc1q3DAUhUVpaaZp91kVQTfduNGfJSu7EJq2EMgmhe6MLF8nCpblStY0s-sqL5A3zJNUw-QHAl1JcL5z7pUOQgeUfKFUqUPCpJK1poxoIrWUr9CKCqUqSumv12i1lautvofepXRNCBFC8LdojzMqKG_YCt1eXAHOCXAYMNws0dgQ5xDBjNiD76KZinSzuYTJLC5M2E34KntTLt7nKfQwOOtgshu8djGn-793c0hucWvAc3HAtKQjbHCEtYM_2yEG-zwuzhYFIu7NYjqT4D16M5gxwYeHcx_9PP16cfK9Ojv_9uPk-KyyXNZLxWsJTKveEEV0X3cNgU4xBQR0p-XQUNFbxqGhAwNOjGSNspJYajS3igrg--jzLneO4XeGtLTeJQvjWN4ZcmoZV4KXL-WqoJ9eoNchx6ls1zIhua55I1ihyI6yMaQUYWjn6LyJm5aSdttR-7KjYvn4EJw7D_2T4bGUAlQ7IJlLeJ7638B_7F2b0Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2463953842</pqid></control><display><type>article</type><title>The use of extracorporeal membrane oxygenation in human immunodeficiency virus–positive patients: a review of a multicenter database</title><source>MEDLINE</source><source>Sage Journals</source><creator>Brogan, Thomas V ; Thiagarajan, Ravi R ; Lorusso, Roberto ; McMullan, D Michael ; Di Nardo, Matteo ; Ogino, Mark T ; Dalton, Heidi J ; Burke, Christopher R ; Capatos, Gerry</creator><creatorcontrib>Brogan, Thomas V ; Thiagarajan, Ravi R ; Lorusso, Roberto ; McMullan, D Michael ; Di Nardo, Matteo ; Ogino, Mark T ; Dalton, Heidi J ; Burke, Christopher R ; Capatos, Gerry</creatorcontrib><description>Aim:
We chose to evaluate the survival of extracorporeal membrane oxygenation among patients with human immunodeficiency virus in a multicenter registry.
Methods:
Retrospective case review of the Extracorporeal Life Support Organization Registry respiratory failure of all patients with human immunodeficiency virus supported with extracorporeal membrane oxygenation.
Results:
A total of 126 patients were included. Survival to discharge was 36%. Eight infants were supported with extracorporeal membrane oxygenation and three (37.5%) survived to discharge. Respiratory extracorporeal membrane oxygenation was the primary indication (78%) with a 39% survival, while cardiac and extracorporeal cardiopulmonary resuscitation indications accounted for 16% and 6% of patients with survivals of 30% and 12.5%, respectively. These differences did not reach significance. There were no significant differences between survivors and non-survivors in demographic data, but non-survivors had significantly more non–human immunodeficiency virus pre–extracorporeal membrane oxygenation infections than survivors. There were no differences in other pre–extracorporeal membrane oxygenation supportive therapies, mechanical ventilator settings, or arterial blood gas results between survivors and non-survivors. The median duration of mechanical ventilation prior to cannulation was 52 (interquartile range: 13-140) hours, while the median duration of the extracorporeal membrane oxygenation exposure was 237 (interquartile range: 125-622) hours. Ventilator settings were significantly lower after 24 hours compared to pre–extracorporeal membrane oxygenation settings. Complications during extracorporeal membrane oxygenation exposure including receipt of renal replacement therapy, inotropic infusions, and cardiopulmonary resuscitation were more common among non-survivors compared to survivors. Central nervous system complications were rare.
Conclusion:
Survival among patients with human immunodeficiency virus infection who receive extracorporeal membrane oxygenation was less than 40%. Infections before extracorporeal membrane oxygenation cannulation occurred more often in non-survivors. The receipt of renal replacement therapy, inotropic infusions, or cardiopulmonary resuscitation during extracorporeal membrane oxygenation was associated with worse outcome.</description><identifier>ISSN: 0267-6591</identifier><identifier>EISSN: 1477-111X</identifier><identifier>DOI: 10.1177/0267659120906966</identifier><identifier>PMID: 32141382</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Cannulation ; Cardiopulmonary resuscitation ; Central nervous system ; Complications ; CPR ; Exposure ; Extracorporeal membrane oxygenation ; Extracorporeal Membrane Oxygenation - methods ; Female ; HIV ; HIV - immunology ; Human immunodeficiency virus ; Humans ; Infants ; Infections ; Male ; Mechanical ventilation ; Membranes ; Middle Aged ; Oxygenation ; Renal replacement therapy ; Respiratory failure ; Resuscitation ; Retrospective Studies ; Survival ; Ventilation ; Ventilators ; Viruses</subject><ispartof>Perfusion, 2020-11, Vol.35 (8), p.772-777</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-356e297da0709d5b80eb727e0e9b96f814dc23e81f2e30a6287c60c1a93c714e3</citedby><cites>FETCH-LOGICAL-c365t-356e297da0709d5b80eb727e0e9b96f814dc23e81f2e30a6287c60c1a93c714e3</cites><orcidid>0000-0003-0051-8080 ; 0000-0001-8315-8337 ; 0000-0002-1777-2045</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0267659120906966$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0267659120906966$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32141382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brogan, Thomas V</creatorcontrib><creatorcontrib>Thiagarajan, Ravi R</creatorcontrib><creatorcontrib>Lorusso, Roberto</creatorcontrib><creatorcontrib>McMullan, D Michael</creatorcontrib><creatorcontrib>Di Nardo, Matteo</creatorcontrib><creatorcontrib>Ogino, Mark T</creatorcontrib><creatorcontrib>Dalton, Heidi J</creatorcontrib><creatorcontrib>Burke, Christopher R</creatorcontrib><creatorcontrib>Capatos, Gerry</creatorcontrib><title>The use of extracorporeal membrane oxygenation in human immunodeficiency virus–positive patients: a review of a multicenter database</title><title>Perfusion</title><addtitle>Perfusion</addtitle><description>Aim:
We chose to evaluate the survival of extracorporeal membrane oxygenation among patients with human immunodeficiency virus in a multicenter registry.
Methods:
Retrospective case review of the Extracorporeal Life Support Organization Registry respiratory failure of all patients with human immunodeficiency virus supported with extracorporeal membrane oxygenation.
Results:
A total of 126 patients were included. Survival to discharge was 36%. Eight infants were supported with extracorporeal membrane oxygenation and three (37.5%) survived to discharge. Respiratory extracorporeal membrane oxygenation was the primary indication (78%) with a 39% survival, while cardiac and extracorporeal cardiopulmonary resuscitation indications accounted for 16% and 6% of patients with survivals of 30% and 12.5%, respectively. These differences did not reach significance. There were no significant differences between survivors and non-survivors in demographic data, but non-survivors had significantly more non–human immunodeficiency virus pre–extracorporeal membrane oxygenation infections than survivors. There were no differences in other pre–extracorporeal membrane oxygenation supportive therapies, mechanical ventilator settings, or arterial blood gas results between survivors and non-survivors. The median duration of mechanical ventilation prior to cannulation was 52 (interquartile range: 13-140) hours, while the median duration of the extracorporeal membrane oxygenation exposure was 237 (interquartile range: 125-622) hours. Ventilator settings were significantly lower after 24 hours compared to pre–extracorporeal membrane oxygenation settings. Complications during extracorporeal membrane oxygenation exposure including receipt of renal replacement therapy, inotropic infusions, and cardiopulmonary resuscitation were more common among non-survivors compared to survivors. Central nervous system complications were rare.
Conclusion:
Survival among patients with human immunodeficiency virus infection who receive extracorporeal membrane oxygenation was less than 40%. Infections before extracorporeal membrane oxygenation cannulation occurred more often in non-survivors. The receipt of renal replacement therapy, inotropic infusions, or cardiopulmonary resuscitation during extracorporeal membrane oxygenation was associated with worse outcome.</description><subject>Adult</subject><subject>Cannulation</subject><subject>Cardiopulmonary resuscitation</subject><subject>Central nervous system</subject><subject>Complications</subject><subject>CPR</subject><subject>Exposure</subject><subject>Extracorporeal membrane oxygenation</subject><subject>Extracorporeal Membrane Oxygenation - methods</subject><subject>Female</subject><subject>HIV</subject><subject>HIV - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infants</subject><subject>Infections</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Membranes</subject><subject>Middle Aged</subject><subject>Oxygenation</subject><subject>Renal replacement therapy</subject><subject>Respiratory failure</subject><subject>Resuscitation</subject><subject>Retrospective Studies</subject><subject>Survival</subject><subject>Ventilation</subject><subject>Ventilators</subject><subject>Viruses</subject><issn>0267-6591</issn><issn>1477-111X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1q3DAUhUVpaaZp91kVQTfduNGfJSu7EJq2EMgmhe6MLF8nCpblStY0s-sqL5A3zJNUw-QHAl1JcL5z7pUOQgeUfKFUqUPCpJK1poxoIrWUr9CKCqUqSumv12i1lautvofepXRNCBFC8LdojzMqKG_YCt1eXAHOCXAYMNws0dgQ5xDBjNiD76KZinSzuYTJLC5M2E34KntTLt7nKfQwOOtgshu8djGn-793c0hucWvAc3HAtKQjbHCEtYM_2yEG-zwuzhYFIu7NYjqT4D16M5gxwYeHcx_9PP16cfK9Ojv_9uPk-KyyXNZLxWsJTKveEEV0X3cNgU4xBQR0p-XQUNFbxqGhAwNOjGSNspJYajS3igrg--jzLneO4XeGtLTeJQvjWN4ZcmoZV4KXL-WqoJ9eoNchx6ls1zIhua55I1ihyI6yMaQUYWjn6LyJm5aSdttR-7KjYvn4EJw7D_2T4bGUAlQ7IJlLeJ7638B_7F2b0Q</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Brogan, Thomas V</creator><creator>Thiagarajan, Ravi R</creator><creator>Lorusso, Roberto</creator><creator>McMullan, D Michael</creator><creator>Di Nardo, Matteo</creator><creator>Ogino, Mark T</creator><creator>Dalton, Heidi J</creator><creator>Burke, Christopher R</creator><creator>Capatos, Gerry</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0051-8080</orcidid><orcidid>https://orcid.org/0000-0001-8315-8337</orcidid><orcidid>https://orcid.org/0000-0002-1777-2045</orcidid></search><sort><creationdate>202011</creationdate><title>The use of extracorporeal membrane oxygenation in human immunodeficiency virus–positive patients: a review of a multicenter database</title><author>Brogan, Thomas V ; Thiagarajan, Ravi R ; Lorusso, Roberto ; McMullan, D Michael ; Di Nardo, Matteo ; Ogino, Mark T ; Dalton, Heidi J ; Burke, Christopher R ; Capatos, Gerry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-356e297da0709d5b80eb727e0e9b96f814dc23e81f2e30a6287c60c1a93c714e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Cannulation</topic><topic>Cardiopulmonary resuscitation</topic><topic>Central nervous system</topic><topic>Complications</topic><topic>CPR</topic><topic>Exposure</topic><topic>Extracorporeal membrane oxygenation</topic><topic>Extracorporeal Membrane Oxygenation - methods</topic><topic>Female</topic><topic>HIV</topic><topic>HIV - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infants</topic><topic>Infections</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Membranes</topic><topic>Middle Aged</topic><topic>Oxygenation</topic><topic>Renal replacement therapy</topic><topic>Respiratory failure</topic><topic>Resuscitation</topic><topic>Retrospective Studies</topic><topic>Survival</topic><topic>Ventilation</topic><topic>Ventilators</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brogan, Thomas V</creatorcontrib><creatorcontrib>Thiagarajan, Ravi R</creatorcontrib><creatorcontrib>Lorusso, Roberto</creatorcontrib><creatorcontrib>McMullan, D Michael</creatorcontrib><creatorcontrib>Di Nardo, Matteo</creatorcontrib><creatorcontrib>Ogino, Mark T</creatorcontrib><creatorcontrib>Dalton, Heidi J</creatorcontrib><creatorcontrib>Burke, Christopher R</creatorcontrib><creatorcontrib>Capatos, Gerry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Perfusion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brogan, Thomas V</au><au>Thiagarajan, Ravi R</au><au>Lorusso, Roberto</au><au>McMullan, D Michael</au><au>Di Nardo, Matteo</au><au>Ogino, Mark T</au><au>Dalton, Heidi J</au><au>Burke, Christopher R</au><au>Capatos, Gerry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of extracorporeal membrane oxygenation in human immunodeficiency virus–positive patients: a review of a multicenter database</atitle><jtitle>Perfusion</jtitle><addtitle>Perfusion</addtitle><date>2020-11</date><risdate>2020</risdate><volume>35</volume><issue>8</issue><spage>772</spage><epage>777</epage><pages>772-777</pages><issn>0267-6591</issn><eissn>1477-111X</eissn><abstract>Aim:
We chose to evaluate the survival of extracorporeal membrane oxygenation among patients with human immunodeficiency virus in a multicenter registry.
Methods:
Retrospective case review of the Extracorporeal Life Support Organization Registry respiratory failure of all patients with human immunodeficiency virus supported with extracorporeal membrane oxygenation.
Results:
A total of 126 patients were included. Survival to discharge was 36%. Eight infants were supported with extracorporeal membrane oxygenation and three (37.5%) survived to discharge. Respiratory extracorporeal membrane oxygenation was the primary indication (78%) with a 39% survival, while cardiac and extracorporeal cardiopulmonary resuscitation indications accounted for 16% and 6% of patients with survivals of 30% and 12.5%, respectively. These differences did not reach significance. There were no significant differences between survivors and non-survivors in demographic data, but non-survivors had significantly more non–human immunodeficiency virus pre–extracorporeal membrane oxygenation infections than survivors. There were no differences in other pre–extracorporeal membrane oxygenation supportive therapies, mechanical ventilator settings, or arterial blood gas results between survivors and non-survivors. The median duration of mechanical ventilation prior to cannulation was 52 (interquartile range: 13-140) hours, while the median duration of the extracorporeal membrane oxygenation exposure was 237 (interquartile range: 125-622) hours. Ventilator settings were significantly lower after 24 hours compared to pre–extracorporeal membrane oxygenation settings. Complications during extracorporeal membrane oxygenation exposure including receipt of renal replacement therapy, inotropic infusions, and cardiopulmonary resuscitation were more common among non-survivors compared to survivors. Central nervous system complications were rare.
Conclusion:
Survival among patients with human immunodeficiency virus infection who receive extracorporeal membrane oxygenation was less than 40%. Infections before extracorporeal membrane oxygenation cannulation occurred more often in non-survivors. The receipt of renal replacement therapy, inotropic infusions, or cardiopulmonary resuscitation during extracorporeal membrane oxygenation was associated with worse outcome.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32141382</pmid><doi>10.1177/0267659120906966</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0051-8080</orcidid><orcidid>https://orcid.org/0000-0001-8315-8337</orcidid><orcidid>https://orcid.org/0000-0002-1777-2045</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0267-6591 |
| ispartof | Perfusion, 2020-11, Vol.35 (8), p.772-777 |
| issn | 0267-6591 1477-111X |
| language | eng |
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| source | MEDLINE; Sage Journals |
| subjects | Adult Cannulation Cardiopulmonary resuscitation Central nervous system Complications CPR Exposure Extracorporeal membrane oxygenation Extracorporeal Membrane Oxygenation - methods Female HIV HIV - immunology Human immunodeficiency virus Humans Infants Infections Male Mechanical ventilation Membranes Middle Aged Oxygenation Renal replacement therapy Respiratory failure Resuscitation Retrospective Studies Survival Ventilation Ventilators Viruses |
| title | The use of extracorporeal membrane oxygenation in human immunodeficiency virus–positive patients: a review of a multicenter database |
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