Phosphate-sensing and regulatory mechanism of FGF23 production

Background Inorganic phosphate (Pi) is an essential mineral for human. Hypophosphatemia and hyperphosphatemia cause rickets/osteomalacia and ectopic calcification, respectively, indicating that serum Pi level needs to be regulated. Fibroblast growth factor (FGF) 23 is a principal hormone to regulate...

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Veröffentlicht in:	Journal of endocrinological investigation 2020-07, Vol.43 (7), p.877-883
Hauptverfasser:	Takashi, Y., Fukumoto, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone and Bones - metabolism Calcification (ectopic) Endocrinology Fibroblast growth factor receptor 1 Fibroblast growth factor receptors Fibroblast Growth Factor-23 Fibroblast Growth Factors - genetics Fibroblast Growth Factors - physiology Homeostasis - genetics Humans Hyperphosphatemia Hypophosphatemia Internal Medicine Intestine Intracellular signalling Kidney - metabolism Klotho protein Medicine Medicine & Public Health Metabolic Diseases N-Acetylgalactosaminyltransferases - genetics N-Acetylgalactosaminyltransferases - metabolism Osteoblasts Osteocytes Osteomalacia Phosphates - metabolism Polypeptide N-acetylgalactosaminyltransferase Post-translation Reabsorption Receptor, Fibroblast Growth Factor, Type 1 - genetics Receptor, Fibroblast Growth Factor, Type 1 - metabolism Regulation Rickets Short Review Signal transduction Signal Transduction - physiology Vitamin D Vitamin D - metabolism
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