Peri-thrombus vascular hyperintensity sign: detection of intracranial thrombus location and length in acute ischemic stroke
Purpose The aim of the study was to investigate the diagnostic accuracy of peri-thrombus vascular hyperintensity sign (PVHS) on three-dimensional (3D) black-blood (BB) contrast-enhanced MRI for the detection of intracranial thrombus location and length in acute ischemic stroke (AIS) patients. Materi...
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| Veröffentlicht in: | Japanese journal of radiology 2020-06, Vol.38 (6), p.516-523 |
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| creator | Chen, Qian Wang, Wei Chen, Yu-Chen Chen, Guozhong Ni, Ling Zhang, Danfeng Zhou, Junshan Yin, Xin-dao |
| description | Purpose
The aim of the study was to investigate the diagnostic accuracy of peri-thrombus vascular hyperintensity sign (PVHS) on three-dimensional (3D) black-blood (BB) contrast-enhanced MRI for the detection of intracranial thrombus location and length in acute ischemic stroke (AIS) patients.
Materials and methods
Consecutive AIS patients who underwent MRI including 3D BB contrast-enhanced MRI sequence within 8 h of clinical onset were prospectively evaluated. Two readers independently reviewed the 3D BB contrast-enhanced MRI data to assess the presence and location of PVHS. Findings were compared with those of contrast-enhanced MR angiography (CE-MRA) as the reference standard.
Results
The PVHS was identified in 49% (63/129) of AIS patients with good agreement. The PVHS had 100% specificity, 88% negative predictive value, 89% sensitivity, and 100% positive predictive value for detection of acute arterial occlusions. Eight patients showed discordant thrombus locations between 3D BB contrast-enhanced MRI and CE-MRA. Median thrombus length in patients with complete occlusion was 9.61 mm.
Conclusion
The PVHS on 3D BB contrast-enhanced MRI is a highly specific tool for evaluating the location and length of a thrombus in AIS patients. |
| doi_str_mv | 10.1007/s11604-020-00937-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2374358658</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2405963412</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-1f38d8b4534a3bb93557cc85f3c930811b6371c84c93ea7ee6e57b10738af0cd3</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhq0KVD7aP9ADssSll4CdsROntwqVDwkJDiD1ZjnOZDc0sRfbQVr1z2NYupU4cJoZvc-8Husl5BtnJ5yx-jRyXjFRsJIVjDVQF_wT2eeqyg1Tv3e2fc33yEGMD4xVAoT4TPag5EJIKfbJ31sMQ5GWwU_tHOmTiXYeTaDL9SoLLqGLQ1rTOCzcD9phQpsG76jvaRaDscG4wYx0azB6a14J4zo6olukZSapsXNCOkS7xGmwNKbg_-AXstubMeLXt3pI7s9_3Z1dFtc3F1dnP68LKxpIBe9BdaoVEoSBtm1AytpaJXuwDTDFeVtBza0SeURTI1Yo6zZ_G5Tpme3gkHzf-K6Cf5wxJj3lS3AcjUM_R11CLUCqSqqMHr9DH_wcXL5Ol1IJpUrefEwJJpsKBC8zVW4oG3yMAXu9CsNkwlpzpl8C1JsAdQ5QvwaoeV46erOe2wm77cq_xDIAGyBmyS0w_H_7A9tndb-nEg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2405963412</pqid></control><display><type>article</type><title>Peri-thrombus vascular hyperintensity sign: detection of intracranial thrombus location and length in acute ischemic stroke</title><source>SpringerLink Journals - AutoHoldings</source><creator>Chen, Qian ; Wang, Wei ; Chen, Yu-Chen ; Chen, Guozhong ; Ni, Ling ; Zhang, Danfeng ; Zhou, Junshan ; Yin, Xin-dao</creator><creatorcontrib>Chen, Qian ; Wang, Wei ; Chen, Yu-Chen ; Chen, Guozhong ; Ni, Ling ; Zhang, Danfeng ; Zhou, Junshan ; Yin, Xin-dao</creatorcontrib><description>Purpose
The aim of the study was to investigate the diagnostic accuracy of peri-thrombus vascular hyperintensity sign (PVHS) on three-dimensional (3D) black-blood (BB) contrast-enhanced MRI for the detection of intracranial thrombus location and length in acute ischemic stroke (AIS) patients.
Materials and methods
Consecutive AIS patients who underwent MRI including 3D BB contrast-enhanced MRI sequence within 8 h of clinical onset were prospectively evaluated. Two readers independently reviewed the 3D BB contrast-enhanced MRI data to assess the presence and location of PVHS. Findings were compared with those of contrast-enhanced MR angiography (CE-MRA) as the reference standard.
Results
The PVHS was identified in 49% (63/129) of AIS patients with good agreement. The PVHS had 100% specificity, 88% negative predictive value, 89% sensitivity, and 100% positive predictive value for detection of acute arterial occlusions. Eight patients showed discordant thrombus locations between 3D BB contrast-enhanced MRI and CE-MRA. Median thrombus length in patients with complete occlusion was 9.61 mm.
Conclusion
The PVHS on 3D BB contrast-enhanced MRI is a highly specific tool for evaluating the location and length of a thrombus in AIS patients.</description><identifier>ISSN: 1867-1071</identifier><identifier>EISSN: 1867-108X</identifier><identifier>DOI: 10.1007/s11604-020-00937-1</identifier><identifier>PMID: 32144554</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Angiography ; Blood clots ; Diagnostic systems ; Evaluation ; Imaging ; Ischemia ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Nuclear Medicine ; Occlusion ; Original Article ; Patients ; Radiology ; Radiotherapy ; Stroke ; Thrombosis</subject><ispartof>Japanese journal of radiology, 2020-06, Vol.38 (6), p.516-523</ispartof><rights>Japan Radiological Society 2020</rights><rights>Japan Radiological Society 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-1f38d8b4534a3bb93557cc85f3c930811b6371c84c93ea7ee6e57b10738af0cd3</citedby><cites>FETCH-LOGICAL-c493t-1f38d8b4534a3bb93557cc85f3c930811b6371c84c93ea7ee6e57b10738af0cd3</cites><orcidid>0000-0001-6958-5201</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11604-020-00937-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11604-020-00937-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32144554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Qian</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Chen, Yu-Chen</creatorcontrib><creatorcontrib>Chen, Guozhong</creatorcontrib><creatorcontrib>Ni, Ling</creatorcontrib><creatorcontrib>Zhang, Danfeng</creatorcontrib><creatorcontrib>Zhou, Junshan</creatorcontrib><creatorcontrib>Yin, Xin-dao</creatorcontrib><title>Peri-thrombus vascular hyperintensity sign: detection of intracranial thrombus location and length in acute ischemic stroke</title><title>Japanese journal of radiology</title><addtitle>Jpn J Radiol</addtitle><addtitle>Jpn J Radiol</addtitle><description>Purpose
The aim of the study was to investigate the diagnostic accuracy of peri-thrombus vascular hyperintensity sign (PVHS) on three-dimensional (3D) black-blood (BB) contrast-enhanced MRI for the detection of intracranial thrombus location and length in acute ischemic stroke (AIS) patients.
Materials and methods
Consecutive AIS patients who underwent MRI including 3D BB contrast-enhanced MRI sequence within 8 h of clinical onset were prospectively evaluated. Two readers independently reviewed the 3D BB contrast-enhanced MRI data to assess the presence and location of PVHS. Findings were compared with those of contrast-enhanced MR angiography (CE-MRA) as the reference standard.
Results
The PVHS was identified in 49% (63/129) of AIS patients with good agreement. The PVHS had 100% specificity, 88% negative predictive value, 89% sensitivity, and 100% positive predictive value for detection of acute arterial occlusions. Eight patients showed discordant thrombus locations between 3D BB contrast-enhanced MRI and CE-MRA. Median thrombus length in patients with complete occlusion was 9.61 mm.
Conclusion
The PVHS on 3D BB contrast-enhanced MRI is a highly specific tool for evaluating the location and length of a thrombus in AIS patients.</description><subject>Angiography</subject><subject>Blood clots</subject><subject>Diagnostic systems</subject><subject>Evaluation</subject><subject>Imaging</subject><subject>Ischemia</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Medicine</subject><subject>Occlusion</subject><subject>Original Article</subject><subject>Patients</subject><subject>Radiology</subject><subject>Radiotherapy</subject><subject>Stroke</subject><subject>Thrombosis</subject><issn>1867-1071</issn><issn>1867-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1P3DAQhq0KVD7aP9ADssSll4CdsROntwqVDwkJDiD1ZjnOZDc0sRfbQVr1z2NYupU4cJoZvc-8Husl5BtnJ5yx-jRyXjFRsJIVjDVQF_wT2eeqyg1Tv3e2fc33yEGMD4xVAoT4TPag5EJIKfbJ31sMQ5GWwU_tHOmTiXYeTaDL9SoLLqGLQ1rTOCzcD9phQpsG76jvaRaDscG4wYx0azB6a14J4zo6olukZSapsXNCOkS7xGmwNKbg_-AXstubMeLXt3pI7s9_3Z1dFtc3F1dnP68LKxpIBe9BdaoVEoSBtm1AytpaJXuwDTDFeVtBza0SeURTI1Yo6zZ_G5Tpme3gkHzf-K6Cf5wxJj3lS3AcjUM_R11CLUCqSqqMHr9DH_wcXL5Ol1IJpUrefEwJJpsKBC8zVW4oG3yMAXu9CsNkwlpzpl8C1JsAdQ5QvwaoeV46erOe2wm77cq_xDIAGyBmyS0w_H_7A9tndb-nEg</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Chen, Qian</creator><creator>Wang, Wei</creator><creator>Chen, Yu-Chen</creator><creator>Chen, Guozhong</creator><creator>Ni, Ling</creator><creator>Zhang, Danfeng</creator><creator>Zhou, Junshan</creator><creator>Yin, Xin-dao</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6958-5201</orcidid></search><sort><creationdate>20200601</creationdate><title>Peri-thrombus vascular hyperintensity sign: detection of intracranial thrombus location and length in acute ischemic stroke</title><author>Chen, Qian ; Wang, Wei ; Chen, Yu-Chen ; Chen, Guozhong ; Ni, Ling ; Zhang, Danfeng ; Zhou, Junshan ; Yin, Xin-dao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-1f38d8b4534a3bb93557cc85f3c930811b6371c84c93ea7ee6e57b10738af0cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Angiography</topic><topic>Blood clots</topic><topic>Diagnostic systems</topic><topic>Evaluation</topic><topic>Imaging</topic><topic>Ischemia</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nuclear Medicine</topic><topic>Occlusion</topic><topic>Original Article</topic><topic>Patients</topic><topic>Radiology</topic><topic>Radiotherapy</topic><topic>Stroke</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Qian</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Chen, Yu-Chen</creatorcontrib><creatorcontrib>Chen, Guozhong</creatorcontrib><creatorcontrib>Ni, Ling</creatorcontrib><creatorcontrib>Zhang, Danfeng</creatorcontrib><creatorcontrib>Zhou, Junshan</creatorcontrib><creatorcontrib>Yin, Xin-dao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Qian</au><au>Wang, Wei</au><au>Chen, Yu-Chen</au><au>Chen, Guozhong</au><au>Ni, Ling</au><au>Zhang, Danfeng</au><au>Zhou, Junshan</au><au>Yin, Xin-dao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peri-thrombus vascular hyperintensity sign: detection of intracranial thrombus location and length in acute ischemic stroke</atitle><jtitle>Japanese journal of radiology</jtitle><stitle>Jpn J Radiol</stitle><addtitle>Jpn J Radiol</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>38</volume><issue>6</issue><spage>516</spage><epage>523</epage><pages>516-523</pages><issn>1867-1071</issn><eissn>1867-108X</eissn><abstract>Purpose
The aim of the study was to investigate the diagnostic accuracy of peri-thrombus vascular hyperintensity sign (PVHS) on three-dimensional (3D) black-blood (BB) contrast-enhanced MRI for the detection of intracranial thrombus location and length in acute ischemic stroke (AIS) patients.
Materials and methods
Consecutive AIS patients who underwent MRI including 3D BB contrast-enhanced MRI sequence within 8 h of clinical onset were prospectively evaluated. Two readers independently reviewed the 3D BB contrast-enhanced MRI data to assess the presence and location of PVHS. Findings were compared with those of contrast-enhanced MR angiography (CE-MRA) as the reference standard.
Results
The PVHS was identified in 49% (63/129) of AIS patients with good agreement. The PVHS had 100% specificity, 88% negative predictive value, 89% sensitivity, and 100% positive predictive value for detection of acute arterial occlusions. Eight patients showed discordant thrombus locations between 3D BB contrast-enhanced MRI and CE-MRA. Median thrombus length in patients with complete occlusion was 9.61 mm.
Conclusion
The PVHS on 3D BB contrast-enhanced MRI is a highly specific tool for evaluating the location and length of a thrombus in AIS patients.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>32144554</pmid><doi>10.1007/s11604-020-00937-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6958-5201</orcidid></addata></record> |
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| identifier | ISSN: 1867-1071 |
| ispartof | Japanese journal of radiology, 2020-06, Vol.38 (6), p.516-523 |
| issn | 1867-1071 1867-108X |
| language | eng |
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| subjects | Angiography Blood clots Diagnostic systems Evaluation Imaging Ischemia Magnetic resonance imaging Medicine Medicine & Public Health Nuclear Medicine Occlusion Original Article Patients Radiology Radiotherapy Stroke Thrombosis |
| title | Peri-thrombus vascular hyperintensity sign: detection of intracranial thrombus location and length in acute ischemic stroke |
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