Von Willebrand Factor Deficiency Improves Hepatic Steatosis, Insulin Resistance, and Inflammation in Mice Fed High‐Fat Diet
Objective The aim of this study was to investigate the effect of Von Willebrand factor (VWF) on high‐fat diet (HFD)‐induced hepatic steatosis, insulin resistance, and inflammation in mice. Methods The expression of VWF was detected in obese mice. Wild‐type and VWF knockout mice were fed a normal cho...
Gespeichert in:
| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2020-04, Vol.28 (4), p.756-764 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 764 |
|---|---|
| container_issue | 4 |
| container_start_page | 756 |
| container_title | Obesity (Silver Spring, Md.) |
| container_volume | 28 |
| creator | Yang, Juan Lu, Yan Lou, Xudan Wang, Jian Yu, Huilin Bao, Zhijun Wang, Haidong |
| description | Objective
The aim of this study was to investigate the effect of Von Willebrand factor (VWF) on high‐fat diet (HFD)‐induced hepatic steatosis, insulin resistance, and inflammation in mice.
Methods
The expression of VWF was detected in obese mice. Wild‐type and VWF knockout mice were fed a normal chow diet or an HFD, and then biomedical, histological, and metabolic analyses were conducted to identify pathologic alterations. Inflammatory cytokine levels and the number of hepatic macrophages were determined in these mice fed an HFD.
Results
VWF expression was significantly increased in obese mice. VWF−/− mice were less obese and had improved hepatic steatosis, balance of lipid metabolism, and insulin resistance in response to HFD. Furthermore, VWF deficiency attenuated HFD‐induced systemic and hepatic inflammation. In addition, VWF deficiency rescued the abnormal accumulation of hepatic macrophages.
Conclusions
These data demonstrated VWF deficiency improves hepatic steatosis, insulin resistance, and inflammation. Furthermore, the protective effects are mediated via regulation of hepatic macrophages. |
| doi_str_mv | 10.1002/oby.22744 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2374357741</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2385399421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3534-74e5f1e42a772c8eba8b7bbeaacd9bf3f37bba219ca17b1bc2965d2fbdb99d5e3</originalsourceid><addsrcrecordid>eNp1kc1OGzEQxy1URPjooS9QWeqlSIT4a_H6SIGQSKki0Rba08r2zrZGu96w3gXtAYlH4Bl5EhyS5lCpp5nR_PTTjP4IfaDkmBLCRrXpjxmTQmyhXao4GUqufr7b9CkdoL0QbgkRJyShO2jAGRUiTckueryuPb5xZQmm0T7HY23busHnUDjrwNseT6tFU99DwBNY6NZZ_K0F3dbBhSM89aErncdXEMdWewtHeGmZ-qLUVRXxaI_7r84CHkOOJ-73n5en57Fu8bmD9gBtF7oM8H5d99GP8cX3s8lwNr-cnp3OhpYnXAylgKSgIJiWktkUjE6NNAa0trkyBS94nDSjymoqDTWWqZMkZ4XJjVJ5AnwffV554yt3HYQ2q1ywUJbaQ92FjHEpeCKloBH99A96W3eNj9dFKk24UoItqcMVZZs6hAaKbNG4Sjd9Rkm2zCSLmWRvmUT249rYmQryDfk3hAiMVsCDK6H_vymbf_m1Ur4CQbGX-A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2385399421</pqid></control><display><type>article</type><title>Von Willebrand Factor Deficiency Improves Hepatic Steatosis, Insulin Resistance, and Inflammation in Mice Fed High‐Fat Diet</title><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><creator>Yang, Juan ; Lu, Yan ; Lou, Xudan ; Wang, Jian ; Yu, Huilin ; Bao, Zhijun ; Wang, Haidong</creator><creatorcontrib>Yang, Juan ; Lu, Yan ; Lou, Xudan ; Wang, Jian ; Yu, Huilin ; Bao, Zhijun ; Wang, Haidong</creatorcontrib><description>Objective
The aim of this study was to investigate the effect of Von Willebrand factor (VWF) on high‐fat diet (HFD)‐induced hepatic steatosis, insulin resistance, and inflammation in mice.
Methods
The expression of VWF was detected in obese mice. Wild‐type and VWF knockout mice were fed a normal chow diet or an HFD, and then biomedical, histological, and metabolic analyses were conducted to identify pathologic alterations. Inflammatory cytokine levels and the number of hepatic macrophages were determined in these mice fed an HFD.
Results
VWF expression was significantly increased in obese mice. VWF−/− mice were less obese and had improved hepatic steatosis, balance of lipid metabolism, and insulin resistance in response to HFD. Furthermore, VWF deficiency attenuated HFD‐induced systemic and hepatic inflammation. In addition, VWF deficiency rescued the abnormal accumulation of hepatic macrophages.
Conclusions
These data demonstrated VWF deficiency improves hepatic steatosis, insulin resistance, and inflammation. Furthermore, the protective effects are mediated via regulation of hepatic macrophages.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.22744</identifier><identifier>PMID: 32144880</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Cytokines ; Diet ; Fatty acids ; Food ; Gene expression ; Glucose ; Inflammation ; Insulin resistance ; Kinases ; Laboratory animals ; Lipids ; Liver ; Metabolic disorders ; Obesity ; Proteins ; Studies ; Tumor necrosis factor-TNF</subject><ispartof>Obesity (Silver Spring, Md.), 2020-04, Vol.28 (4), p.756-764</ispartof><rights>2020 The Obesity Society</rights><rights>2020 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Apr 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-74e5f1e42a772c8eba8b7bbeaacd9bf3f37bba219ca17b1bc2965d2fbdb99d5e3</citedby><cites>FETCH-LOGICAL-c3534-74e5f1e42a772c8eba8b7bbeaacd9bf3f37bba219ca17b1bc2965d2fbdb99d5e3</cites><orcidid>0000-0002-1833-2586</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.22744$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.22744$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32144880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Juan</creatorcontrib><creatorcontrib>Lu, Yan</creatorcontrib><creatorcontrib>Lou, Xudan</creatorcontrib><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Yu, Huilin</creatorcontrib><creatorcontrib>Bao, Zhijun</creatorcontrib><creatorcontrib>Wang, Haidong</creatorcontrib><title>Von Willebrand Factor Deficiency Improves Hepatic Steatosis, Insulin Resistance, and Inflammation in Mice Fed High‐Fat Diet</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
The aim of this study was to investigate the effect of Von Willebrand factor (VWF) on high‐fat diet (HFD)‐induced hepatic steatosis, insulin resistance, and inflammation in mice.
Methods
The expression of VWF was detected in obese mice. Wild‐type and VWF knockout mice were fed a normal chow diet or an HFD, and then biomedical, histological, and metabolic analyses were conducted to identify pathologic alterations. Inflammatory cytokine levels and the number of hepatic macrophages were determined in these mice fed an HFD.
Results
VWF expression was significantly increased in obese mice. VWF−/− mice were less obese and had improved hepatic steatosis, balance of lipid metabolism, and insulin resistance in response to HFD. Furthermore, VWF deficiency attenuated HFD‐induced systemic and hepatic inflammation. In addition, VWF deficiency rescued the abnormal accumulation of hepatic macrophages.
Conclusions
These data demonstrated VWF deficiency improves hepatic steatosis, insulin resistance, and inflammation. Furthermore, the protective effects are mediated via regulation of hepatic macrophages.</description><subject>Cytokines</subject><subject>Diet</subject><subject>Fatty acids</subject><subject>Food</subject><subject>Gene expression</subject><subject>Glucose</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Lipids</subject><subject>Liver</subject><subject>Metabolic disorders</subject><subject>Obesity</subject><subject>Proteins</subject><subject>Studies</subject><subject>Tumor necrosis factor-TNF</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kc1OGzEQxy1URPjooS9QWeqlSIT4a_H6SIGQSKki0Rba08r2zrZGu96w3gXtAYlH4Bl5EhyS5lCpp5nR_PTTjP4IfaDkmBLCRrXpjxmTQmyhXao4GUqufr7b9CkdoL0QbgkRJyShO2jAGRUiTckueryuPb5xZQmm0T7HY23busHnUDjrwNseT6tFU99DwBNY6NZZ_K0F3dbBhSM89aErncdXEMdWewtHeGmZ-qLUVRXxaI_7r84CHkOOJ-73n5en57Fu8bmD9gBtF7oM8H5d99GP8cX3s8lwNr-cnp3OhpYnXAylgKSgIJiWktkUjE6NNAa0trkyBS94nDSjymoqDTWWqZMkZ4XJjVJ5AnwffV554yt3HYQ2q1ywUJbaQ92FjHEpeCKloBH99A96W3eNj9dFKk24UoItqcMVZZs6hAaKbNG4Sjd9Rkm2zCSLmWRvmUT249rYmQryDfk3hAiMVsCDK6H_vymbf_m1Ur4CQbGX-A</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Yang, Juan</creator><creator>Lu, Yan</creator><creator>Lou, Xudan</creator><creator>Wang, Jian</creator><creator>Yu, Huilin</creator><creator>Bao, Zhijun</creator><creator>Wang, Haidong</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1833-2586</orcidid></search><sort><creationdate>202004</creationdate><title>Von Willebrand Factor Deficiency Improves Hepatic Steatosis, Insulin Resistance, and Inflammation in Mice Fed High‐Fat Diet</title><author>Yang, Juan ; Lu, Yan ; Lou, Xudan ; Wang, Jian ; Yu, Huilin ; Bao, Zhijun ; Wang, Haidong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-74e5f1e42a772c8eba8b7bbeaacd9bf3f37bba219ca17b1bc2965d2fbdb99d5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cytokines</topic><topic>Diet</topic><topic>Fatty acids</topic><topic>Food</topic><topic>Gene expression</topic><topic>Glucose</topic><topic>Inflammation</topic><topic>Insulin resistance</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Lipids</topic><topic>Liver</topic><topic>Metabolic disorders</topic><topic>Obesity</topic><topic>Proteins</topic><topic>Studies</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Juan</creatorcontrib><creatorcontrib>Lu, Yan</creatorcontrib><creatorcontrib>Lou, Xudan</creatorcontrib><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Yu, Huilin</creatorcontrib><creatorcontrib>Bao, Zhijun</creatorcontrib><creatorcontrib>Wang, Haidong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Juan</au><au>Lu, Yan</au><au>Lou, Xudan</au><au>Wang, Jian</au><au>Yu, Huilin</au><au>Bao, Zhijun</au><au>Wang, Haidong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Von Willebrand Factor Deficiency Improves Hepatic Steatosis, Insulin Resistance, and Inflammation in Mice Fed High‐Fat Diet</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2020-04</date><risdate>2020</risdate><volume>28</volume><issue>4</issue><spage>756</spage><epage>764</epage><pages>756-764</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
The aim of this study was to investigate the effect of Von Willebrand factor (VWF) on high‐fat diet (HFD)‐induced hepatic steatosis, insulin resistance, and inflammation in mice.
Methods
The expression of VWF was detected in obese mice. Wild‐type and VWF knockout mice were fed a normal chow diet or an HFD, and then biomedical, histological, and metabolic analyses were conducted to identify pathologic alterations. Inflammatory cytokine levels and the number of hepatic macrophages were determined in these mice fed an HFD.
Results
VWF expression was significantly increased in obese mice. VWF−/− mice were less obese and had improved hepatic steatosis, balance of lipid metabolism, and insulin resistance in response to HFD. Furthermore, VWF deficiency attenuated HFD‐induced systemic and hepatic inflammation. In addition, VWF deficiency rescued the abnormal accumulation of hepatic macrophages.
Conclusions
These data demonstrated VWF deficiency improves hepatic steatosis, insulin resistance, and inflammation. Furthermore, the protective effects are mediated via regulation of hepatic macrophages.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>32144880</pmid><doi>10.1002/oby.22744</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1833-2586</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1930-7381 |
| ispartof | Obesity (Silver Spring, Md.), 2020-04, Vol.28 (4), p.756-764 |
| issn | 1930-7381 1930-739X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2374357741 |
| source | Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content |
| subjects | Cytokines Diet Fatty acids Food Gene expression Glucose Inflammation Insulin resistance Kinases Laboratory animals Lipids Liver Metabolic disorders Obesity Proteins Studies Tumor necrosis factor-TNF |
| title | Von Willebrand Factor Deficiency Improves Hepatic Steatosis, Insulin Resistance, and Inflammation in Mice Fed High‐Fat Diet |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T08%3A23%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Von%20Willebrand%20Factor%20Deficiency%20Improves%20Hepatic%20Steatosis,%20Insulin%20Resistance,%20and%20Inflammation%20in%20Mice%20Fed%20High%E2%80%90Fat%20Diet&rft.jtitle=Obesity%20(Silver%20Spring,%20Md.)&rft.au=Yang,%20Juan&rft.date=2020-04&rft.volume=28&rft.issue=4&rft.spage=756&rft.epage=764&rft.pages=756-764&rft.issn=1930-7381&rft.eissn=1930-739X&rft_id=info:doi/10.1002/oby.22744&rft_dat=%3Cproquest_cross%3E2385399421%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2385399421&rft_id=info:pmid/32144880&rfr_iscdi=true |