Cetuximab versus bevacizumab in metastatic colorectal cancer: a comparative effectiveness study

Purpose Uncertainty exists regarding comparative effectiveness of cetuximab versus bevacizumab in metastatic colorectal cancer (mCRC). We conducted a retrospective head-to-head multi-cohort study comparing clinical outcomes from both antibodies Methods Cohorts were defined by treatment line and subg...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2020-05, Vol.146 (5), p.1321-1334
Hauptverfasser:	Marques, Rui Pedro, Godinho, Ana Rita, Heudtlass, Peter, Pais, Helena Luna, Quintela, António, Martins, Ana Paula
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents, Immunological - administration & dosage Antineoplastic Agents, Immunological - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Bevacizumab - administration & dosage Bevacizumab - therapeutic use Cancer Research Cetuximab - administration & dosage Cetuximab - therapeutic use Cohort Studies Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Colorectal carcinoma Female Hematology Humans Immunotherapy Internal Medicine Male Medicine Medicine & Public Health Metastases Metastasis Middle Aged Monoclonal antibodies Mutation Neoplasm Staging Oncology Original Article – Clinical Oncology Patients Proto-Oncogene Proteins p21(ras) - genetics Rectal Neoplasms - drug therapy Rectal Neoplasms - genetics Rectal Neoplasms - pathology Response rates Retrospective Studies Survival Targeted cancer therapy Tumors
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